CYP11B2 CLIA Kit for Human(Homo sapiens) | EIAab.comCYP11B2 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CYP11B2(Gene name) > Human

CYP11B2 (Gene name),

Cytochrome P450 11B2, mitochondrial (Protein name ), C11B2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYP11B2;

Protein name:

Cytochrome P450 11B2, mitochondrial;

Alternative:

Aldosterone-synthesizing enzyme;1.14.15.4;Aldosterone synthase(ALDOS);Cytochrome P-450Aldo;CYPXIB2;Steroid 18-hydroxylase;Cytochrome P-450C18;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.

Subcellular Location:

Mitochondrion membrane

Protein Attributes:

Sequence length:

503

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

503:

AIN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.632054

SMR:

P19099

String:

P19099

STRING:

9606.ENSP00000325822

Pfam:

PF00067

MIM:

103900

KEGG:

hsa:1585

Uniprot:

P19099

FOR

ELISA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

E9018h

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Packing:

96T

ELISA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

E9018m

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MSDS:

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Packing:

96T

ELISA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

E9018r

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Packing:

96T

CLIA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

U9018m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

U9018h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Cytochrome P450 11B2, mitochondrial

Cat.:

U9018r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Cytochrome P450 11B2, mitochondrial

Cat.:

P9018Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 11B2, mitochondrial

Cat.:

P9018Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 11B2, mitochondrial

Cat.:

P9018Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 11B2, mitochondrial

Protein for Human Cytochrome P450 11B2, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)."
Mornet E. , Dupont J. , Vitek A. , White P.C.
J. Biol. Chem.264:20961-20967(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism."
Kawamoto T. , Mitsuuchi Y. , Ohnishi T. , Ichikawa Y. , Yokoyama Y. , Sumimoto H. , Toda K. , Miyahara K. , Kuribayashi I. , Nakao K. , Hosoda K. , Yamamoto Y. , Imura H. , Shizuta Y.
Biochem. Biophys. Res. Commun.173:309-316(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Adrenal gland.
3.

Kawamoto T. , Miyahara K. , Mitsuuchi Y. , Ulick S. , Shizuta Y.
Submitted (1994-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Blood.
4.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Structural insights into aldosterone synthase substrate specificity and targeted inhibition."
Strushkevich N. , Gilep A.A. , Shen L. , Arrowsmith C.H. , Edwards A.M. , Usanov S.A. , Park H.W.
Mol. Endocrinol.27:315-324(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 34-503 IN COMPLEXES WITH HEME; DESOXYCORTICOSTERONE AND SYNTHETIC INHIBITOR FADROZOLE;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
7.

"Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency."
Pascoe L. , Curnow K.M. , Slutsker L. , Roesler A. , White P.C.
Proc. Natl. Acad. Sci. U.S.A.89:4996-5000(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMO-2 DEFICIENCY TRP-181 AND ALA-386
8.

"Congenitally defective aldosterone biosynthesis in humans: the involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients."
Mitsuuchi Y. , Kawamoto T. , Naiki Y. , Miyahara K. , Toda K. , Kuribayashi I. , Orii T. , Yasuda K. , Miura K. , Nakao K. , Imura H. , Ulick S. , Shizuta Y.
Biochem. Biophys. Res. Commun.182:974-979(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMO-2 DEFICIENCY TRP-181 AND ALA-386
9.

Mitsuuchi Y. , Kawamoto T. , Naiki Y. , Miyahara K. , Toda K. , Kuribayashi I. , Orii T. , Yasuda K. , Miura K. , Nakao K. , Imura H. , Ulick S. , Shizuta Y.
Biochem. Biophys. Res. Commun.184:1529-1530(1992)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450(C18) gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients."
Mitsuuchi Y. , Kawamoto T. , Miyahara K. , Ulick S. , Morton D.H. , Naiki Y. , Kuribayashi I. , Toda K. , Hara T. , Orii T. , Yasuda K. , Miura K. , Yamamoto Y. , Imura H. , Shizuta Y.
Biochem. Biophys. Res. Commun.190:864-869(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
11.

"CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18)."
Nomoto S. , Massa G. , Mitani F. , Ishimura Y. , Miyahara K. , Toda K. , Nagano I. , Yamashiro T. , Ogoshi S. , Fukata J. , Onishi S. , Hashimoto K. , Doi Y. , Imura H. , Shizuta Y.
Biochem. Biophys. Res. Commun.234:382-385(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMO-1 DEFICIENCY PRO-461
12.

"Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II."
Peter M. , Buenger K. , Solyom J. , Sippell W.G.
Eur. J. Pediatr.157:378-381(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMO-2 DEFICIENCY ILE-185
13.

"Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene."
Portrat-Doyen S. , Tourniaire J. , Richard O. , Mulatero P. , Aupetit-Faisant B. , Curnow K.M. , Pascoe L. , Morel Y.
J. Clin. Endocrinol. Metab.83:4156-4161(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMO-2 DEFICIENCY ASP-198 AND ALA-386
14.

"Genetic polymorphism of CYP11B2 gene and hypertension in Japanese."
Tamaki S. , Iwai N. , Tsujita Y. , Kinoshita M.
Hypertension33:266-270(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-173
15.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-29; GLN-30; ARG-173; THR-248; SER-281; THR-339; ALA-386 AND SER-435
16.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
17.

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-173; THR-248; SER-281; THR-339; ALA-386 AND SER-435
18.

"Type 1 aldosterone synthase deficiency presenting in a middle-aged man."
Kayes-Wandover K.M. , Schindler R.E.L. , Taylor H.C. , White P.C.
J. Clin. Endocrinol. Metab.86:1008-1012(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMO-1 DEFICIENCY ARG-LEU-140 INS
19.

"A compound heterozygote case of type II aldosterone synthase deficiency."
Dunlop F.M. , Crock P.A. , Montalto J. , Funder J.W. , Curnow K.M.
J. Clin. Endocrinol. Metab.88:2518-2526(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMO-2 DEFICIENCY ILE-185 AND ALA-498

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