C6 CLIA Kit for Human(Homo sapiens) | EIAab.comC6 CLIA Kit for Human(Homo sapiens)

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C6 (Gene name),

Complement component C6 (Protein name ), CO6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

C6;

Protein name:

Complement component C6;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

Function:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

934

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

934:

GSSTSEKTLN | ICEVGTIRCA | NRKMEILHPG | KCLA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

217050

String:

P13671

SMR:

P13671

Pfam:

PF07648

STRING:

9606.ENSP00000263413

UniGene:

Hs.481992

KEGG:

hsa:729

Uniprot:

P13671

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ELISA Kit for Human Complement component C6

Cat.:

E14964h

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96T

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ELISA Kit for Human Complement component C6

Cat.:

E14964r

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96T

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ELISA Kit for Human Complement component C6

Cat.:

E14964b

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Packing:

96T

CLIA Kit for Human Complement component C6

Cat.:

U14964h

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C6

Cat.:

U14964b

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C6

Cat.:

U14964r

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96T

Polyclonal Antibody for Human Complement component C6

Cat.:

P14964Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement component C6

Cat.:

P14964Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Complement component C6

Protein for Human Complement component C6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6."
Haefliger J.-A. , Tschopp J. , Vial N. , Jenne D.E.
J. Biol. Chem.264:18041-18051(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 22-31 AND 633-640
2.

"The molecular architecture of human complement component C6."
Discipio R.G. , Hugli T.E.
J. Biol. Chem.264:16197-16206(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-119
3.

"Structure of the human C6 gene."
Hobart M.J. , Fernie B. , Discipio R.G.
Biochemistry32:6198-6205(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-119
tissue: Blood.
4.

"Sequence variation in C6 locus."
Soejima M. , Koda Y.
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLU-119
tissue: Ovary.
7.

"Structural homology of complement protein C6 with other channel-forming proteins of complement."
Chakravarti D.N. , Chakravarti B. , Parra C.A. , Mueller-Eberhard H.J.
Proc. Natl. Acad. Sci. U.S.A.86:2799-2803(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-491;VARIANT GLU-119
8.

"Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement."
Lengweiler S. , Schaller J. , DiScipio R.G. , Rickli E.E.
Biochim. Biophys. Acta1342:13-18(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS IN FACTOR I MODULE 1 REGION
9.

"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-29; TRP-32; TRP-90; TRP-568; TRP-571 AND TRP-574
10.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324 AND ASN-855
tissue: Plasma.
11.

"Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC)."
Aleshin A.E. , Schraufstatter I.U. , Stec B. , Bankston L.A. , Liddington R.C. , DiScipio R.G.
J. Biol. Chem.287:10210-10222(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 22-934;GLYCOSYLATION AT TRP-29; TRP-32; THR-38; ASN-324; THR-392; TRP-568 AND TRP-571;SUBUNIT;DISULFIDE BONDS
12.

"Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B."
Dewald G. , Nothen M.M. , Cichon S.
Biochem. Biophys. Res. Commun.194:458-464(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALLOTYPE C6 A GLU-119
13.

"Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism."
Ikinciogullari A. , Tekin M. , Dogu F. , Reisli I. , Tanir G. , Yi Z. , Garrison N. , Brilliant M.H. , Babacan E.
Eur. J. Pediatr.164:177-179(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN COMPLEMENT COMPONENT 6 DEFICIENCY

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