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Index > Protein center > CRTAM(Gene name) > Human
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  • CRTAM (Gene name),
  • Cytotoxic and regulatory T-cell molecule (Protein name ),  CRTAM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CRTAM;
    Protein name:
    Cytotoxic and regulatory T-cell molecule;
    Alternative:
    Class-I MHC-restricted T-cell-associated molecule;
    CD:
    CD355;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CADM1.
    Function:
    Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    393
    Sequence:
    50:
    MWWRVLSLLA | WFPLQEASLT | NHTETITVEE | GQTLTLKCVT | SLRKNSSLQW | 
    100:
    LTPSGFTIFL | NEYPALKNSK | YQLLHHSANQ | LSITVPNVTL | QDEGVYKCLH | 
    150:
    YSDSVSTKEV | KVIVLATPFK | PILEASVIRK | QNGEEHVVLM | CSTMRSKPPP | 
    200:
    QITWLLGNSM | EVSGGTLHEF | ETDGKKCNTT | STLIIHTYGK | NSTVDCIIRH | 
    250:
    RGLQGRKLVA | PFRFEDLVTD | EETASDALER | NSLSSQDPQQ | PTSTVSVTED | 
    300:
    SSTSEIDKEE | KEQTTQDPDL | TTEANPQYLG | LARKKSGILL | LTLVSFLIFI | 
    350:
    LFIIVQLFIM | KLRKAHVIWK | KENEVSEHTL | ESYRSRSNNE | ETSSEEKNGQ | 
    393:
    SSHPMRCMNY | ITKLYSEAKT | KRKENVQHSK | LEEKHIQVPE | SIV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytotoxic and regulatory T-cell molecule
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    E4301m
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    Packing:
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    ELISA Kit for Human Cytotoxic and regulatory T-cell molecule
    Cat.:
    E4301h
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    Packing:
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    CLIA Kit for Human Cytotoxic and regulatory T-cell molecule
    Cat.:
    U4301h
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    Packing:
    96T
    CLIA Kit for Human Cytotoxic and regulatory T-cell molecule
    Cat.:
    U4301m
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    Packing:
    96T
    Polyclonal Antibody for Human Cytotoxic and regulatory T-cell molecule
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    P4301Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytotoxic and regulatory T-cell molecule
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    P4301Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytotoxic and regulatory T-cell molecule
    Monoclonal Antibody for Human Cytotoxic and regulatory T-cell molecule
    Protein for Human Cytotoxic and regulatory T-cell molecule
    Protein for Human Cytotoxic and regulatory T-cell molecule

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)."
      Kennedy J. , Vicari A.P. , Saylor V. , Zurawski S.M. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Zlotnik A.
      J. Leukoc. Biol.67:725-734(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT ARG-321
    2. 2.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-368
      tissue: Peripheral blood.
    4. 4.
      "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
      Boles K.S. , Barchet W. , Diacovo T. , Cella M. , Colonna M.
      Blood106:779-786(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CADM1;TISSUE SPECIFICITY
    5. 5.
      "Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
      Galibert L. , Diemer G.S. , Liu Z. , Johnson R.S. , Smith J.L. , Walzer T. , Comeau M.R. , Rauch C.T. , Wolfson M.F. , Sorensen R.A. , Van der Vuurst de Vries A.-R. , Branstetter D.G. , Koelling R.M. , Scholler J. , Fanslow W.C. , Baum P.R. , Derry J.M. , Yan W.
      J. Biol. Chem.280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CADM1
    6. 6.
      "Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes."
      Patino-Lopez G. , Hevezi P. , Lee J. , Willhite D. , Verge G.M. , Lechner S.M. , Ortiz-Navarrete V. , Zlotnik A.
      J. Neuroimmunol.171:145-155(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Structure analysis of human class-I MHC restricted T-cell associated molecule."
      New York structural genomics research consortium (NYSGRC)
      Submitted (2011-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 18-117;DISULFIDE BOND
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