Ctcf CLIA Kit for Mouse(Mus musculus) | EIAab.comCtcf CLIA Kit for Mouse(Mus musculus)

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Ctcf (Gene name),

Transcriptional repressor CTCF (Protein name ), CTCF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ctcf;

Protein name:

Transcriptional repressor CTCF;

Alternative:

CCCTC-binding factor;11-zinc finger protein;CTCFL paralog;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CHD8.

Function:

Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates to the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19.

Subcellular Location:

Nucleus nucleoplasm Chromosome Chromosome centromere May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.

Protein Attributes:

Sequence length:

736

Sequence:

50:

100:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

736:

PDAEPAEGEE | EEAQAATTDA | PNGDLTPEMI | LSMMDR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.269474

KEGG:

mmu:13018

STRING:

10090.ENSMUSP00000005841

SMR:

Q61164

String:

Q61164

Pfam:

PF00096

Uniprot:

Q61164

FOR

ELISA Kit for Mouse Transcriptional repressor CTCF

Cat.:

E2612m

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Manual:

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96T

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ELISA Kit for Mouse Transcriptional repressor CTCF

Cat.:

E2612h

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Packing:

96T

ELISA Kit for Mouse Transcriptional repressor CTCF

Cat.:

E2612r

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96T

ELISA Kit for Mouse Transcriptional repressor CTCF

Cat.:

E2612c

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Packing:

96T

CLIA Kit for Mouse Transcriptional repressor CTCF

Cat.:

U2612h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Transcriptional repressor CTCF

Cat.:

U2612r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Transcriptional repressor CTCF

Cat.:

U2612c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Transcriptional repressor CTCF

Cat.:

U2612m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Mouse Transcriptional repressor CTCF

Cat.:

P2612Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Transcriptional repressor CTCF

Cat.:

P2612Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Transcriptional repressor CTCF

Cat.:

P2612Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Transcriptional repressor CTCF

Monoclonal Antibody for Mouse Transcriptional repressor CTCF

Protein for Mouse Transcriptional repressor CTCF

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes."
Filippova G.N. , Fagerlie S. , Klenova E.M. , Myers C. , Dehner Y. , Goodwin G. , Neiman P.E. , Collins S.J. , Lobanenkov V.V.
Mol. Cell. Biol.16:2802-2813(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
strain: BDF1.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Brain.
tissue: Mammary gland.
tissue: Olfactory epithelium.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-201
strain: C57BL/6J.
tissue: Extraembryonic tissue.
tissue: Placenta.
4.

"CTCF, a candidate trans-acting factor for X-inactivation choice."
Chao W. , Huynh K.D. , Spencer R.J. , Davidow L.S. , Lee J.T.
Science295:345-347(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development."
Filippova G.N. , Cheng M.K. , Moore J.M. , Truong J.-P. , Hu Y.J. , Nguyen D.K. , Tsuchiya K.D. , Disteche C.M.
Dev. Cell8:31-42(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus."
Splinter E. , Heath H. , Kooren J. , Palstra R.-J. , Klous P. , Grosveld F. , Galjart N. , de Laat W.
Genes Dev.20:2349-2354(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"CTCF-dependent chromatin insulator is linked to epigenetic remodeling."
Ishihara K. , Oshimura M. , Nakao M.
Mol. Cell23:733-742(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHD8
8.

"CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1."
Ling J.Q. , Li T. , Hu J.F. , Vu T.H. , Chen H.L. , Qiu X.W. , Cherry A.M. , Hoffman A.R.
Science312:269-272(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain."
Bergstroem R. , Whitehead J. , Kurukuti S. , Ohlsson R.
Cell Cycle6:450-454(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein."
Xu N. , Donohoe M.E. , Silva S.S. , Lee J.T.
Nat. Genet.39:1390-1396(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development."
Wan L.-B. , Pan H. , Hannenhalli S. , Cheng Y. , Ma J. , Fedoriw A. , Lobanenkov V. , Latham K.E. , Schultz R.M. , Bartolomei M.S.
Development135:2729-2738(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The CTCF insulator protein is posttranslationally modified by SUMO."
MacPherson M.J. , Beatty L.G. , Zhou W. , Du M. , Sadowski P.D.
Mol. Cell. Biol.29:714-725(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-74 AND LYS-698;MUTAGENESIS OF LYS-74 AND LYS-698

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