MLYCD CLIA Kit for Human(Homo sapiens) | EIAab.comMLYCD CLIA Kit for Human(Homo sapiens)

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Index > Protein center > MLYCD(Gene name) > Human

MLYCD (Gene name),

Malonyl-CoA decarboxylase, mitochondrial (Protein name ), DCMC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MLYCD;

Protein name:

Malonyl-CoA decarboxylase, mitochondrial(MCD);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.

Subcellular Location:

Mitochondrion Cytoplasm Peroxisome

Protein Attributes:

Sequence length:

493

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

493:

MANYRYFLEE | TGPNSTSYLG | SKIIKASEQV | LSLVAQFQKN | SKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:23417

UniGene:

Hs.644610

String:

O95822

STRING:

9606.ENSP00000262430

Pfam:

PF05292

SMR:

O95822

MIM:

248360

Uniprot:

O95822

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ELISA Kit for Human MCD

Cat.:

E9335m

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Manual:

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Packing:

96T

Range:

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ELISA Kit for Human MCD

Cat.:

E9335r

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Packing:

96T

ELISA Kit for Human MCD

Cat.:

E9335h

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MSDS:

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Packing:

96T

CLIA Kit for Human MCD

Cat.:

U9335m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human MCD

Cat.:

U9335r

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MSDS:

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Packing:

96T

CLIA Kit for Human MCD

Cat.:

U9335h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human MCD

Cat.:

P9335Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MCD

Cat.:

P9335Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MCD

Cat.:

P9335Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MCD

Protein for Human MCD

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The molecular basis of malonyl-CoA decarboxylase deficiency."
FitzPatrick D.R. , Hill A. , Tolmie J.L. , Thorburn D.R. , Christodoulou J.
Am. J. Hum. Genet.65:318-326(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL);CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
2.

"MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency."
Sacksteder K.A. , Morrell J.C. , Wanders R.J.A. , Matalon R. , Gould S.J.
J. Biol. Chem.274:24461-24468(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL);FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
tissue: Heart.
3.

"Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase."
Gao J. , Waber L. , Bennett M.J. , Gibson K.M. , Cohen J.C.
J. Lipid Res.40:178-182(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL);CATALYTIC ACTIVITY
4.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS MITOCHONDRIAL AND CYTOPLASMIC+PEROXISOMAL)
tissue: Eye.
tissue: Lung.
6.

"Expression, purification, and characterization of human malonyl-CoA decarboxylase."
Zhou D. , Yuen P. , Chu D. , Thon V. , McConnell S. , Brown S. , Tsang A. , Pena M. , Russell A. , Cheng J.F. , Nadzan A.M. , Barbosa M.S. , Dyck J.R. , Lopaschuk G.D. , Yang G.
Protein Expr. Purif.34:261-269(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
7.

"Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle."
Bouzakri K. , Austin R. , Rune A. , Lassman M.E. , Garcia-Roves P.M. , Berger J.P. , Krook A. , Chibalin A.V. , Zhang B.B. , Zierath J.R.
Diabetes57:1508-1516(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
8.

"A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities."
Ghosh D. , Berg J.M.
J. Am. Chem. Soc.132:3973-3979(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH PEX5
9.

"Structural asymmetry and disulphide bridges among subunits modulate the activity of human Malonyl-CoA Decarboxylase."
Aparicio D. , Perez R. , Carpena X. , Diaz M. , Ferrer J.C. , Loewen P.C. , Fita I.
J. Biol. Chem.288:11907-11919(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 39-493 IN COMPLEX WITH LIGAND REPRESENTING COENZYME A;CATALYTIC ACTIVITY;FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;DISULFIDE BONDS;MUTAGENESIS OF CYS-206; CYS-243 AND GLU-302;IDENTIFICATION BY MASS SPECTROMETRY
10.

"Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations."
Froese D.S. , Forouhar F. , Tran T.H. , Vollmar M. , Kim Y.S. , Lew S. , Neely H. , Seetharaman J. , Shen Y. , Xiao R. , Acton T.B. , Everett J.K. , Cannone G. , Puranik S. , Savitsky P. , Krojer T. , Pilka E.S. , Kiyani W. , more...
Structure21:1182-1192(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 40-490;SUBUNIT;ACTIVE SITE;MUTAGENESIS OF SER-290; SER-329; HIS-423 AND TYR-456

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