Ddr2 CLIA Kit for Mouse(Mus musculus) | EIAab.comDdr2 CLIA Kit for Mouse(Mus musculus)

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Ddr2 (Gene name),

Discoidin domain-containing receptor 2 (Protein name ), DDR2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ddr2(Ntrkr3;Tkt;Tyro10);

Protein name:

Discoidin domain-containing receptor 2(Discoidin domain receptor 2);

Alternative:

Neurotrophic tyrosine kinase, receptor-related 3;CD167 antigen-like family member B;Tyrosine-protein kinase TYRO10;Receptor protein-tyrosine kinase TKT;

CD:

CD167b;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.

Function:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration, cell proliferation, and cell cycle progress. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Depending on the cell type, promotes or inhibits cell proliferation. Can mediate cell cycle arrest in some types of tumor cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

854

Sequence:

50:

100:

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250:

300:

350:

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450:

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650:

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800:

850:

854:

QGAE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00754

UniGene:

Mm.229249

SMR:

Q62371

String:

Q62371

KEGG:

mmu:18214

Uniprot:

Q62371

FOR

ELISA Kit for Mouse Discoidin domain receptor 2

Cat.:

E1505h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse Discoidin domain receptor 2

Cat.:

E1505m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Discoidin domain receptor 2

Cat.:

U1505m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Discoidin domain receptor 2

Cat.:

U1505h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Discoidin domain receptor 2

Cat.:

P1505Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Discoidin domain receptor 2

Cat.:

P1505Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Discoidin domain receptor 2

Protein for Mouse Discoidin domain receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain."
Karn T. , Holtrich U. , Braeuninger A. , Boehme B. , Wolf G. , Ruebsamen-Waigmann H. , Strebhardt K.
Oncogene8:3433-3440(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure and expression of the Tyro 10 receptor tyrosine kinase."
Lai C. , Lemke G.E.
Oncogene9:877-883(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Embryo.
4.

"The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism."
Labrador J.P. , Azcoitia V. , Tuckermann J. , Lin C. , Olaso E. , Manes S. , Bruckner K. , Goergen J.L. , Lemke G. , Yancopoulos G. , Angel P. , Martinez C. , Klein R.
EMBO Rep.2:446-452(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
5.

"Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2."
Olaso E. , Labrador J.-P. , Wang L. , Ikeda K. , Eng F.J. , Klein R. , Lovett D.H. , Lin H.C. , Friedman S.L.
J. Biol. Chem.277:3606-3613(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen."
Ikeda K. , Wang L.H. , Torres R. , Zhao H. , Olaso E. , Eng F.J. , Labrador P. , Klein R. , Lovett D. , Yancopoulos G.D. , Friedman S.L. , Lin H.C.
J. Biol. Chem.277:19206-19212(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SRC AND SHC1;MUTAGENESIS OF TYR-471 AND LYS-608;PHOSPHORYLATION AT TYR-471
7.

"Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice."
Xu L. , Peng H. , Wu D. , Hu K. , Goldring M.B. , Olsen B.R. , Li Y.
J. Biol. Chem.280:548-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UP-REGULATION OF MMP13
8.

"A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse."
Kano K. , Marin de Evsikova C. , Young J. , Wnek C. , Maddatu T.P. , Nishina P.M. , Naggert J.K.
Mol. Endocrinol.22:1866-1880(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLI;TISSUE SPECIFICITY
9.

"Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice."
Kano K. , Kitamura A. , Matsuwaki T. , Morimatsu M. , Naito K.
Mol. Reprod. Dev.77:29-37(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLI;FUNCTION;TISSUE SPECIFICITY

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