Protein name:
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B (By similarity). Interacts with the PRC2/EED-EZH2. complex. Interacts with UBC9 and BAZ2A/TIP5.
Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MPARTAPARV | PALASRAFSL | PDDVRRRLKD | LERDSLTEKE | CVKEKLNLLH |
100:
EFLRTEIKNQ | LCDLETKLHK | EELSEEGYLA | KVKSLLNKDL | SLENGAHAFS |
150:
REANGCLENG | SQTSGEDCRV | VMAEKGKPPK | PVSRLYTPRR | SKSDGETKSE |
200:
VSSSPRITRK | TTRQTTITSH | FPRGPAKRKP | EEEPEKVKSD | DSVDEEKDQE |
250:
EKRRRVTSRE | RVAGLLPAEE | PGRVRPGTHM | EEEGRDDKEE | KRLRSQTKEP |
300:
TPKHKAKEEP | DRDVRPGGAQ | AEMNEGEDKD | EKRHRSQPKD | LASKRRPEEK |
350:
EPERVKPQVS | DEKDEDEKEE | KRRRTTYREL | TEKKMTRTKI | AVVSKTNPPK |
400:
CTECLQYLDD | PELRYEQHPP | DAVEEIQILT | NERLSIFDAN | ESGFESYEDL |
450:
PQHKLTCFSV | YCKRGHLCPI | DTGLIEKDVE | LLFSGSAKPI | YEDDPSPEGG |
500:
INGKNFGPIN | EWWIAGFDGG | EKALLGFSTS | FAEYILMDPS | PEYAPLFSVM |
550:
QEKIYISKIV | VEFLQSNPDS | TYEDLINKIE | TTVPPCMLNL | NRFTEDSLLR |
600:
HAQFVVEQVE | SYDRAGDSDE | QPIFLSPCMR | DLIKLAGVTL | GKRRAERRQT |
650:
IRQPAKEKDK | GPTKATTTKL | VYQIFDTFFA | EQIEKDDKED | KENAFKRRRC |
700:
GVCEICQQPE | CGKCKACKDM | VKFGGSGRSK | QACQKRRCPN | MAMKEADDDE |
750:
EVDDNIPEMP | SPKKMHQGKK | KKQNKNRISW | VGDAVKTDGK | KSYYKKVCID |
800:
SETLEVGDCV | SVIPDDSSKP | LYLARVTALW | EDSSNGQMFH | AHWFCAGTDT |
850:
VLGATSDPLE | LFLVDECEDM | QLSYIHSKVQ | VIYKAPSENW | AMEGGVDPEA |
900:
LMSEDDGKTY | FYQLWYDQDY | ARFESPPKTQ | PTEDNKYKFC | ASCARLAEMR |
950:
QKEIPRVVEQ | LQDLEGRVLY | SLATKNGVQY | RVGDGVYLPP | EAFTFNIKLS |
1000:
SPVKRPRKEP | VDEALYPEHY | RKYSDYIKGS | NLDAPEPYRI | GRIKEIFCSK |
1050:
KSNGRPNETD | IKIRVNKFYR | PENTHKSTPA | SYHADINLLY | WSDEEAVVDF |
1100:
KAVQGRCTVE | YGEDLPQCLQ | DFSAGGPDRF | YFLEAYNAKS | KSFEDPPNHA |
1150:
RSTGNKGKGK | GKGKNRTKSQ | TCEPSELETE | IKLPKLRTLD | VFSGCGGLSE |
1200:
GFHQAGISET | LWAIEMWDPA | AQAFRLNNPG | STVFTEDCNV | LLKLVMAGEV |
1250:
TNSRGQKLPQ | KGDVEMLCGG | PPCQGFSGMN | RFNSRTYSKF | KNSLVVSFLS |
1300:
YCDYYRPRYF | LLENVRNFVS | FKRSMVLKLT | LRCLVRMGYQ | CTFGVLQAGQ |
1350:
YGVAQTRRRA | IILAAAPGEP | LPLFPEPLHV | FAPRACQLSV | VVDDKKFVSN |
1400:
ITRLSSGPFR | TITVRDTMSD | LPEIRNGASA | LEISYNGEPQ | SWFQRQLRGS |
1450:
QYQPILRDHI | CKDMSALVAA | RMRHIPLAPG | SDWRDLPNIE | VRLSDGTLAR |
1500:
KLRYNYHDKK | NGCSSSGALR | GVCSCVEGKP | CEPAARQFNT | LIPWCLPHTG |
1550:
NRHNHWAGLY | GRLEWDGFFS | TTVTNPEPMG | KQGRVLHPEQ | HRVVSVRECA |
1600:
RSQGFPDTYR | LFGNILDKHR | QVGNAVPPPL | AKAIGLEIKR | CMLAKARESA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Bovine
Rat
ELISA Kit for Bovine Dnmt1
ELISA Kit for Bovine Dnmt1
ELISA Kit for Bovine Dnmt1
ELISA Kit for Bovine Dnmt1
ELISA Kit for Bovine Dnmt1
CLIA Kit for Bovine Dnmt1
CLIA Kit for Bovine Dnmt1
CLIA Kit for Bovine Dnmt1
CLIA Kit for Bovine Dnmt1
CLIA Kit for Bovine Dnmt1
Polyclonal Antibody for Bovine Dnmt1
Polyclonal Antibody for Bovine Dnmt1
Polyclonal Antibody for Bovine Dnmt1
Polyclonal Antibody for Bovine Dnmt1
Polyclonal Antibody for Bovine Dnmt1
Monoclonal Antibody for Bovine Dnmt1
Monoclonal Antibody for Bovine Dnmt1
Monoclonal Antibody for Bovine Dnmt1
Monoclonal Antibody for Bovine Dnmt1
Monoclonal Antibody for Bovine Dnmt1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Bovine (Bos taurus) cytosine-5-methyltransferase (Dnmt1) cDNA."
Lee P.
,
Min K.S.
,
Seong H.H.
,
Park J.K.
,
Lee Y.K.
,
Kim S.W.
,
Kim S.J.
,
Lee H.G.
,
Chung H.K.
,
Chang Y.M.
,
Chang W.K.
,
Kwon M.
Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hypothalamus .