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Index > Protein center > SLC1A1(Gene name) > Human
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  • SLC1A1 (Gene name),
  • Excitatory amino acid transporter 3 (Protein name ),  EAA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC1A1(EAAC1;EAAT3);
    Protein name:
    Excitatory amino acid transporter 3;
    Alternative:
    Neuronal and epithelial glutamate transporter;Excitatory amino-acid carrier 1;Solute carrier family 1 member 1;Sodium-dependent glutamate/aspartate transporter 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ARL6IP5/PRAF3.
    Function:
    Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    524
    Sequence:
    50:
    MGKPARKGCE | WKRFLKNNWV | LLSTVAAVVL | GITTGVLVRE | HSNLSTLEKF | 
    100:
    YFAFPGEILM | RMLKLIILPL | IISSMITGVA | ALDSNVSGKI | GLRAVVYYFC | 
    150:
    TTLIAVILGI | VLVVSIKPGV | TQKVGEIART | GSTPEVSTVD | AMLDLIRNMF | 
    200:
    PENLVQACFQ | QYKTKREEVK | PPSDPEMNMT | EESFTAVMTT | AISKNKTKEY | 
    250:
    KIVGMYSDGI | NVLGLIVFCL | VFGLVIGKMG | EKGQILVDFF | NALSDATMKI | 
    300:
    VQIIMCYMPL | GILFLIAGKI | IEVEDWEIFR | KLGLYMATVL | TGLAIHSIVI | 
    350:
    LPLIYFIVVR | KNPFRFAMGM | AQALLTALMI | SSSSATLPVT | FRCAEENNQV | 
    400:
    DKRITRFVLP | VGATINMDGT | ALYEAVAAVF | IAQLNDLDLG | IGQIITISIT | 
    450:
    ATSASIGAAG | VPQAGLVTMV | IVLSAVGLPA | EDVTLIIAVD | WLLDRFRTMV | 
    500:
    NVLGDAFGTG | IVEKLSKKEL | EQMDVSSEVN | IVNPFALEST | ILDNEDSDTK | 
    524:
    KSYVNGGFAV | DKSDTISFTQ | TSQF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    E15516m
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    Packing:
    96T
    ELISA Kit for Human Excitatory amino acid transporter 3
    MSDS:
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    ELISA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    E15516r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    E15516h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    E15516b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    U15516r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    U15516h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    U15516m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 3
    Cat.:
    U15516b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Excitatory amino acid transporter 3
    Cat.:
    P15516Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Excitatory amino acid transporter 3
    Polyclonal Antibody for Human Excitatory amino acid transporter 3
    Cat.:
    P15516Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Excitatory amino acid transporter 3
    Polyclonal Antibody for Human Excitatory amino acid transporter 3
    Cat.:
    P15516Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Excitatory amino acid transporter 3
    Monoclonal Antibody for Human Excitatory amino acid transporter 3
    Monoclonal Antibody for Human Excitatory amino acid transporter 3
    Monoclonal Antibody for Human Excitatory amino acid transporter 3
    Monoclonal Antibody for Human Excitatory amino acid transporter 3
    Protein for Human Excitatory amino acid transporter 3
    Protein for Human Excitatory amino acid transporter 3
    Protein for Human Excitatory amino acid transporter 3
    Protein for Human Excitatory amino acid transporter 3
    Protein for Human Excitatory amino acid transporter 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain."
      Shashidharan P. , Huntley G.W. , Meyer T. , Morrison J.H. , Plaitakis A.
      Brain Res.662:245-250(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport."
      Kanai Y. , Stelzner M. , Nussberger S. , Khawaja S. , Hebert S.C. , Smith C.P. , Hediger M.A.
      J. Biol. Chem.269:20599-20606(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
    3. 3.
      "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex."
      Arriza J.L. , Fairman W.A. , Wendy A. , Wadiche J.I. , Murdoch G.H. , Kavanaugh M.P. , Amara S.G.
      J. Neurosci.14:5559-5569(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Brain cortex.
    4. 4.
      "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder."
      Veenstra-VanderWeele J. , Kim S.J. , Gonen D. , Hanna G.L. , Leventhal B.L. , Cook E.H. Jr.
      Mol. Psychiatry6:160-167(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "A glutamate transporter related to EAAT3 from human brain."
      Yasuda-Kamatani Y.
      Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Brain.
    6. 6.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    8. 8.
      Rome S. , Mertani H.C. , Lee K.O. , Lobie P.E. , Tome D.
      Submitted (1997-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 268-446
      tissue: Placenta.
    9. 9.
      "Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees."
      Melhem N. , Middleton F. , McFadden K. , Klei L. , Faraone S.V. , Vinogradov S. , Tiobech J. , Yano V. , Kuartei S. , Roeder K. , Byerley W. , Devlin B. , Myles-Worsley M.
      Biol. Psychiatry70:1115-1121(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SCZD18
    10. 10.
      "Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family."
      Myles-Worsley M. , Tiobech J. , Browning S.R. , Korn J. , Goodman S. , Gentile K. , Melhem N. , Byerley W. , Faraone S.V. , Middleton F.A.
      Am. J. Med. Genet. B Neuropsychiatr. Genet.162B:87-95(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SCZD18
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