ERAP2 CLIA Kit for Human(Homo sapiens) | EIAab.comERAP2 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > ERAP2(Gene name) > Human

ERAP2 (Gene name),

Endoplasmic reticulum aminopeptidase 2 (Protein name ), ERAP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ERAP2(LRAP);

Protein name:

Endoplasmic reticulum aminopeptidase 2;

Alternative:

Leukocyte-derived arginine aminopeptidase(L-RAP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with ERAP1.

Function:

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

960

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

960:

TLRTWLMVNT |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q6P179

UniGene:

Hs.482910

STRING:

9606.ENSP00000342447

Pfam:

PF01433

SMR:

Q6P179

MIM:

609497

Pfam:

PF11838

KEGG:

hsa:64167

Uniprot:

Q6P179

FOR

ELISA Kit for Human Endoplasmic reticulum aminopeptidase 2

Cat.:

E15293h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Endoplasmic reticulum aminopeptidase 2

Cat.:

E15293b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Endoplasmic reticulum aminopeptidase 2

Cat.:

U15293h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Endoplasmic reticulum aminopeptidase 2

Cat.:

U15293b

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Endoplasmic reticulum aminopeptidase 2

Cat.:

P15293Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Endoplasmic reticulum aminopeptidase 2

Protein for Human Endoplasmic reticulum aminopeptidase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases."
Tanioka T. , Hattori A. , Masuda S. , Nomura Y. , Nakayama H. , Mizutani S. , Tsujimoto M.
J. Biol. Chem.278:32275-32283(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;ENZYME ACTIVITY;SUBCELLULAR LOCATION;GLYCOSYLATION;TOPOLOGY;TISSUE SPECIFICITY;VARIANT ASN-392
2.

"Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma."
Tanioka T. , Hattori A. , Mizutani S. , Tsujimoto M.
FEBS J.272:916-928(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION BY IFNG;VARIANT ASN-392
3.

"Molecular characterization of aminopeptidase MAMS."
Schomburg L.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
tissue: Skeletal muscle.
tissue: Skin.
6.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119
tissue: Plasma.
7.

"Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum."
Saveanu L. , Carroll O. , Lindo V. , Del Val M. , Lopez D. , Lepelletier Y. , Greer F. , Schomburg L. , Fruci D. , Niedermann G. , van Endert P.M.
Nat. Immunol.6:689-697(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INDUCTION BY IFNG
8.

"The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a 'molecular ruler' mechanism."
Chang S.-C. , Momburg F. , Bhutani N. , Goldberg A.L.
Proc. Natl. Acad. Sci. U.S.A.102:17107-17112(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines."
Fruci D. , Ferracuti S. , Limongi M.Z. , Cunsolo V. , Giorda E. , Fraioli R. , Sibilio L. , Carroll O. , Hattori A. , van Endert P.M. , Giacomini P.
J. Immunol.176:4869-4879(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE REGULATION
10.

"Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis."
Pinyol M. , Bea S. , Pla L. , Ribrag V. , Bosq J. , Rosenwald A. , Campo E. , Jares P.
Blood109:5422-5429(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing."
Birtley J.R. , Saridakis E. , Stratikos E. , Mavridis I.M.
Biochemistry51:286-295(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.08 ANGSTROMS) OF 3-960 IN COMPLEX WITH SUBSTRATE;GLYCOSYLATION AT ASN-85; ASN-219; ASN-405 AND ASN-650;ACTIVE SITE;ZINC-BINDING SITES;SUBUNIT;DISULFIDE BONDS

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