FFAR1 CLIA Kit for Human(Homo sapiens) | EIAab.comFFAR1 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > FFAR1(Gene name) > Human

FFAR1 (Gene name),

Free fatty acid receptor 1 (Protein name ), FFAR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FFAR1(GPR40);

Protein name:

Free fatty acid receptor 1;

Alternative:

G-protein coupled receptor 40;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

300

Sequence:

50:

100:

150:

200:

250:

300:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O14842

STRING:

9606.ENSP00000246553

Pfam:

PF00001

UniGene:

Hs.248127

String:

O14842

MIM:

603820

KEGG:

hsa:2864

Uniprot:

O14842

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ELISA Kit for Human Free fatty acid receptor 1

Cat.:

E9934h

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96T

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ELISA Kit for Human Free fatty acid receptor 1

Cat.:

E9934m

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96T

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ELISA Kit for Human Free fatty acid receptor 1

Cat.:

E9934r

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96T

CLIA Kit for Human Free fatty acid receptor 1

Cat.:

U9934m

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96T

CLIA Kit for Human Free fatty acid receptor 1

Cat.:

U9934r

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96T

CLIA Kit for Human Free fatty acid receptor 1

Cat.:

U9934h

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Polyclonal Antibody for Human Free fatty acid receptor 1

Cat.:

P9934Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Free fatty acid receptor 1

Cat.:

P9934Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Free fatty acid receptor 1

Cat.:

P9934Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Free fatty acid receptor 1

Protein for Human Free fatty acid receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
Sawzdargo M. , George S.R. , Nguyen T. , Xu S. , Kolakowski L.F. Jr. , O'Dowd B.F.
Biochem. Biophys. Res. Commun.239:543-547(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-211
3.

"The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids."
Briscoe C.P. , Tadayyon M. , Andrews J.L. , Benson W.G. , Chambers J.K. , Eilert M.M. , Ellis C. , Elshourbagy N.A. , Goetz A.S. , Minnick D.T. , Murdock P.R. , Sauls H.R. Jr. , Shabon U. , Spinage L.D. , Strum J.C. , Szekeres P.G. , Tan K.B. , Way J.M. , more...
J. Biol. Chem.278:11303-11311(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
4.

"GPR40 gene expression in human pancreas and insulinoma."
Tomita T. , Masuzaki H. , Noguchi M. , Iwakura H. , Fujikura J. , Tanaka T. , Ebihara K. , Kawamura J. , Komoto I. , Kawaguchi Y. , Fujimoto K. , Doi R. , Shimada Y. , Hosoda K. , Imamura M. , Nakao K.
Biochem. Biophys. Res. Commun.338:1788-1790(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Identification of residues important for agonist recognition and activation in GPR40."
Sum C.S. , Tikhonova I.G. , Neumann S. , Engel S. , Raaka B.M. , Costanzi S. , Gershengorn M.C.
J. Biol. Chem.282:29248-29255(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-12; TYR-91; HIS-137; ARG-183; TYR-240; ASN-244 AND ARG-258
6.

"Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation."
Sum C.S. , Tikhonova I.G. , Costanzi S. , Gershengorn M.C.
J. Biol. Chem.284:3529-3536(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLU-145 AND GLU-172;SITE
7.

"Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40."
Kruska N. , Reiser G.
Neurobiol. Dis.43:465-472(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
8.

"A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1."
Yabuki C. , Komatsu H. , Tsujihata Y. , Maeda R. , Ito R. , Matsuda-Nagasumi K. , Sakuma K. , Miyawaki K. , Kikuchi N. , Takeuchi K. , Habata Y. , Mori M.
PLoS ONE8:E76280-E76280(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
9.

"High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875."
Srivastava A. , Yano J. , Hirozane Y. , Kefala G. , Gruswitz F. , Snell G. , Lane W. , Ivetac A. , Aertgeerts K. , Nguyen J. , Jennings A. , Okada K.
Nature513:124-127(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 1-211 AND 214-300 IN COMPLEX WITH THE AGONIST TAK-875;AGONIST BINDING SITES;SUBCELLULAR LOCATION;TOPOLOGY;DISULFIDE BOND;MUTAGENESIS OF TYR-91; ARG-183; TYR-240; ASN-244 AND ARG-258

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