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Index > Protein center > FFAR4(Gene name) > Human
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  • FFAR4 (Gene name),
  • Free fatty acid receptor 4 (Protein name ),  FFAR4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FFAR4(GPR120;GPR129;O3FAR1;PGR4);
    Protein name:
    Free fatty acid receptor 4;
    Alternative:
    G-protein coupled receptor 129;G-protein coupled receptor 120;G-protein coupled receptor PGR4;G-protein coupled receptor GT01;Omega-3 fatty acid receptor 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.
    Function:
    Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Colocalized with ARRB2 following DHA treatment.
    Protein Attributes:
    Sequence length:
    377
    Sequence:
    50:
    MSPECARAAG | DAPLRSLEQA | NRTRFPFFSD | VKGDHRLVLA | AVETTVLVLI | 
    100:
    FAVSLLGNVC | ALVLVARRRR | RGATACLVLN | LFCADLLFIS | AIPLVLAVRW | 
    150:
    TEAWLLGPVA | CHLLFYVMTL | SGSVTILTLA | AVSLERMVCI | VHLQRGVRGP | 
    200:
    GRRARAVLLA | LIWGYSAVAA | LPLCVFFRVV | PQRLPGADQE | ISICTLIWPT | 
    250:
    IPGEISWDVS | FVTLNFLVPG | LVIVISYSKI | LQTSEHLLDA | RAVVTHSEIT | 
    300:
    KASRKRLTVS | LAYSESHQIR | VSQQDFRLFR | TLFLLMVSFF | IMWSPIIITI | 
    350:
    LLILIQNFKQ | DLVIWPSLFF | WVVAFTFANS | ALNPILYNMT | LCRNEWKKIF | 
    377:
    CCFWFPEKGA | ILTDTSVKRN | DLSIISG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Free fatty acid receptor 4
    Cat.:
    E15282r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Free fatty acid receptor 4
    Cat.:
    E15282h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Free fatty acid receptor 4
    Cat.:
    E15282m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Free fatty acid receptor 4
    Cat.:
    U15282m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Free fatty acid receptor 4
    Cat.:
    U15282h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Free fatty acid receptor 4
    Cat.:
    U15282r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Free fatty acid receptor 4
    Cat.:
    P15282Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Free fatty acid receptor 4
    Cat.:
    P15282Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Free fatty acid receptor 4
    Cat.:
    P15282Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Free fatty acid receptor 4
    Monoclonal Antibody for Human Free fatty acid receptor 4
    Monoclonal Antibody for Human Free fatty acid receptor 4
    Protein for Human Free fatty acid receptor 4
    Protein for Human Free fatty acid receptor 4
    Protein for Human Free fatty acid receptor 4

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    References
    1. 1.
      "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R. , Hoeglund P.J. , Gloriam D.E.I. , Lagerstroem M.C. , Schioeth H.B.
      FEBS Lett.554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120."
      Hirasawa A. , Tsumaya K. , Awaji T. , Katsuma S. , Adachi T. , Yamada M. , Sugimoto Y. , Miyazaki S. , Tsujimoto G.
      Nat. Med.11:90-94(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANT CYS-67
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-312 (ISOFORM 2)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    8. 8.
      "Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor."
      Burns R.N. , Moniri N.H.
      Biochem. Biophys. Res. Commun.396:1030-1035(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BMIQ10;VARIANTS CYS-67 AND HIS-270;ASSOCIATION OF VARIANT HIS-270 WITH RISK OF OBESITY
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