FGF19 CLIA Kit for Human(Homo sapiens) | EIAab.comFGF19 CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > FGF19(Gene name) > Human

FGF19 (Gene name),

Fibroblast growth factor 19 (Protein name ), FGF19_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

FGF19(UNQ334/PRO533);

Protein name:

Fibroblast growth factor 19(FGF-19);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB.

Function:

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

216

Sequence:

50:

100:

150:

200:

216:

GLVTGLEAVR | SPSFEK

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

O95750

MIM:

603891

STRING:

9606.ENSP00000294312

UniGene:

Hs.249200

Pfam:

PF00167

KEGG:

hsa:9965

String:

O95750

Uniprot:

O95750

FOR

ELISA Kit for Human FGF-19

Cat.:

E15626h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human FGF-19

Cat.:

U15626h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human FGF-19

Cat.:

P15626Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human FGF-19

Protein for Human FGF-19

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain."
Nishimura T. , Utsunomiya Y. , Hoshikawa M. , Ohuchi H. , Itoh N.
Biochim. Biophys. Acta1444:148-151(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4."
Xie M.-H. , Holcomb I. , Deuel B. , Dowd P. , Huang A. , Vagts A. , Foster J. , Liang J. , Brush J. , Gu Q. , Hillan K. , Goddard A. , Gurney A.L.
Cytokine11:729-735(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INTERACTION WITH FGFR4;RECEPTOR SPECIFICITY
3.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
6.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
7.

"Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis."
Holt J.A. , Luo G. , Billin A.N. , Bisi J. , McNeill Y.Y. , Kozarsky K.F. , Donahee M. , Wang D.Y. , Mansfield T.A. , Kliewer S.A. , Goodwin B. , Jones S.A.
Genes Dev.17:1581-1591(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY NR1H4;FUNCTION
8.

"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X. , Ibrahimi O.A. , Olsen S.K. , Umemori H. , Mohammadi M. , Ornitz D.M.
J. Biol. Chem.281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4;FUNCTION IN STIMULATION OF CELL PROLIFERATION
9.

"Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."
Kurosu H. , Choi M. , Ogawa Y. , Dickson A.S. , Goetz R. , Eliseenkova A.V. , Mohammadi M. , Rosenblatt K.P. , Kliewer S.A. , Kuro-o M.
J. Biol. Chem.282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FGFR4 AND KLB
10.

"C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
Wu X. , Lemon B. , Li X. , Gupte J. , Weiszmann J. , Stevens J. , Hawkins N. , Shen W. , Lindberg R. , Chen J.-L. , Tian H. , Li Y.
J. Biol. Chem.283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR4; KL AND KLB
11.

"Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression."
Song K.H. , Li T. , Owsley E. , Strom S. , Chiang J.Y.
Hepatology49:297-305(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Fibroblast growth factor signalling: from development to cancer."
Turner N. , Grose R.
Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity."
Harmer N.J. , Pellegrini L. , Chirgadze D. , Fernandez-Recio J. , Blundell T.L.
Biochemistry43:629-640(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 39-196;DISULFIDE BONDS
14.

"Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members."
Goetz R. , Beenken A. , Ibrahimi O.A. , Kalinina J. , Olsen S.K. , Eliseenkova A.V. , Xu C. , Neubert T.A. , Zhang F. , Linhardt R.J. , Yu X. , White K.E. , Inagaki T. , Kliewer S.A. , Yamamoto M. , Kurosu H. , Ogawa Y. , Kuro-o M. , more...
Mol. Cell. Biol.27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 23-216;INTERACTION WITH KLB

Product Feedback Wall

* Email:
*Comments: