Protein name:
Frataxin, mitochondrial (Fxn) ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Monomer (probable predominant form). Oligomer. Interacts with LYRM4 AND HSPA9. Interacts with ACO1. Interacts with ISCU. Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB. Interacts with ACO2; the interation is dependent on citrate.
Function:
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1.
Subcellular Location:
Cytoplasm
Mitochondrion
Protein Attributes:
50:
MWTLGRRSVA | SFLPRSALPG | FAPTRAGAPR | PAKDLSLSGL | PGLRIGTAKA |
100:
PARSQSSLSL | RCLNQTLDVK | KQSVCWINLR | TAGTLGDAGT | LDDTTYERLA |
150:
EETLDSLAEF | FEDLADKPYT | FEDYDVSFGS | GVLTVKLGGD | LGTYVINKQT |
200:
PNKQIWLSSP | SSGPKRYDWT | GRNWVYSHDG | VSLHELLATE | LTQALKTKLD |
217:
LSALAYSGKD | TCCPAQC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Bovine
Mouse
Polyclonal Antibody for Bovine Fxn
Polyclonal Antibody for Bovine Fxn
Polyclonal Antibody for Bovine Fxn
Polyclonal Antibody for Bovine Fxn
Monoclonal Antibody for Bovine Fxn
Monoclonal Antibody for Bovine Fxn
Monoclonal Antibody for Bovine Fxn
Monoclonal Antibody for Bovine Fxn
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Thalamus .