GSR CLIA Kit for Human(Homo sapiens) | EIAab.comGSR CLIA Kit for Human(Homo sapiens) | EIAab.com

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GSR (Gene name),

Glutathione reductase, mitochondrial (Protein name ), GSHR_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

GSR(GLUR;GRD1);

Protein name:

Glutathione reductase, mitochondrial(GR;GRase);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked.

Function:

Maintains high levels of reduced glutathione in the cytosol.

Subcellular Location:

Isoform Cytoplasmic Cytoplasm

Protein Attributes:

Sequence length:

522

Sequence:

50:

MALLPRALSA | GAGPSWRRAA | RAFRGFLLLL | PEPAALTRAL | SRAMACRQEP |

100:

QPQGPPPAAG | AVASYDYLVI | GGGSGGLASA | RRAAELGARA | AVVESHKLGG |

150:

TCVNVGCVPK | KVMWNTAVHS | EFMHDHADYG | FPSCEGKFNW | RVIKEKRDAY |

200:

VSRLNAIYQN | NLTKSHIEII | RGHAAFTSDP | KPTIEVSGKK | YTAPHILIAT |

250:

GGMPSTPHES | QIPGASLGIT | SDGFFQLEEL | PGRSVIVGAG | YIAVEMAGIL |

300:

SALGSKTSLM | IRHDKVLRSF | DSMISTNCTE | ELENAGVEVL | KFSQVKEVKK |

350:

TLSGLEVSMV | TAVPGRLPVM | TMIPDVDCLL | WAIGRVPNTK | DLSLNKLGIQ |

400:

TDDKGHIIVD | EFQNTNVKGI | YAVGDVCGKA | LLTPVAIAAG | RKLAHRLFEY |

450:

KEDSKLDYNN | IPTVVFSHPP | IGTVGLTEDE | AIHKYGIENV | KTYSTSFTPM |

500:

YHAVTKRKTK | CVMKMVCANK | EEKVVGIHMQ | GLGCDEMLQG | FAVAVKMGAT |

522:

KADFDNTVAI | HPTSSEELVT | LR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Pfam:

String:

KEGG:

MIM:

UniGene:

STRING:

9606.ENSP00000221130

Uniprot:

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ELISA Kit for Human GR

Cat.:

E2081h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human GR

Cat.:

E2081r

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human GR

Cat.:

E2081m

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human GR

Cat.:

U2081m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human GR

Cat.:

U2081r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human GR

Cat.:

U2081h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human GR

Cat.:

P2081Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GR

Cat.:

P2081Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GR

Cat.:

P2081Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human GR

Monoclonal Antibody for Human GR

Monoclonal Antibody for Human GR

Protein for Human GR

Protein for Human GR

Protein for Human GR

R&D Technical Data

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s

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤8.1%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤10.5%

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Recovery

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Recovery was determined by spiking various levels of GSHR into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	95	92-104
Plasma	96	93-107

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of GSHR and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-97%	90-101%	92-100%	91-99%
EDTA plasma(n=5)	91-103%	94-98%	90-102%	92-99%
heparin plasma(n=5)	93-100%	92-99%	91-101%	90-103%

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References

1.

"Cloning and sequencing of mammalian glutathione reductase cDNA."
Tutic M. , Lu X.A. , Schirmer R.H. , Werner D.
Eur. J. Biochem.188:523-528(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC)
tissue: Placenta.
2.

"Structural organization of the human glutathione reductase (GSR) gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence."
Kelner M.J. , Montoya M.A.
Biochem. Biophys. Res. Commun.269:366-368(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM MITOCHONDRIAL);ALTERNATIVE INITIATION
3.

NIEHS SNPs program
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-153; SER-232; VAL-261 AND ASP-297
4.

"Expression of glutathione reductase splice variants in human tissues."
Satoh N. , Watanabe N. , Kanda A. , Sugaya-Fukazawa M. , Hisatomi H.
Biochem. Genet.48:816-821(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
5.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MITOCHONDRIAL)
tissue: Lung.
8.

"Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain."
Krauth-Siegel R.L. , Blatterspiel R. , Saleh M. , Schiltz E. , Schirmer R.H. , Untucht-Grau R.
Eur. J. Biochem.121:259-267(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-522
9.

"Glutathione reductase from human erythrocytes. Isolation of the enzyme and sequence analysis of the redox-active peptide."
Krohne-Ehrich G. , Schirmer R.H. , Untucht-Grau R.
Eur. J. Biochem.80:65-71(1977) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 98-110
tissue: Erythrocyte.
10.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Three-dimensional structure of glutathione reductase at 2-A resolution."
Thieme R. , Pai E.F. , Schirmer R.H. , Schulz G.E.
J. Mol. Biol.152:763-782(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2 ANGSTROMS) OF 45-522
13.

"Refined structure of glutathione reductase at 1.54-A resolution."
Karplus P.A. , Schulz G.E.
J. Mol. Biol.195:701-729(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) OF 45-522
14.

"Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor."
Savvides S.N. , Karplus P.A.
J. Biol. Chem.271:8101-8107(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 62-522;DISULFIDE BONDS
15.

"Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity."
Stoll V.S. , Simpson S.J. , Krauth-Siegel R.L. , Walsh C.T. , Pai E.F.
Biochemistry36:6437-6447(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 62-522
16.

"Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers."
Becker K. , Savvides S.N. , Keese M. , Schirmer R.H. , Karplus P.A.
Nat. Struct. Biol.5:267-271(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 62-522

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