Huwe1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comHuwe1 CLIA Kit for Rat(Rattus norvegicus)

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Huwe1 (Gene name),

E3 ubiquitin-protein ligase HUWE1 (Protein name ), HUWE1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Huwe1(Ureb1);

Protein name:

E3 ubiquitin-protein ligase HUWE1;

Alternative:

Upstream regulatory element-binding protein 1(URE-B1;URE-binding protein 1);HECT, UBA and WWE domain-containing protein 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with isoform p19ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity (By similarity). Interacts with MYCN, POLB and CDC6.

Function:

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

Subcellular Location:

Cytoplasm Nucleus Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells.

Protein Attributes:

Sequence length:

322

Sequence:

50:

100:

150:

200:

250:

300:

322:

FEKLRHMLLL | AIQECSEGFG | LA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P51593

STRING:

10116.ENSRNOP00000004064

String:

P51593

Pfam:

PF00632

UniGene:

Rn.12130

Uniprot:

P51593

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ELISA Kit for Rat E3 ubiquitin-protein ligase HUWE1

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ELISA Kit for Rat E3 ubiquitin-protein ligase HUWE1

Cat.:

E2369m

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96T

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ELISA Kit for Rat E3 ubiquitin-protein ligase HUWE1

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E2369h

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96T

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CLIA Kit for Rat E3 ubiquitin-protein ligase HUWE1

Cat.:

U2369h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Rat E3 ubiquitin-protein ligase HUWE1

Cat.:

U2369m

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MSDS:

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Packing:

96T

CLIA Kit for Rat E3 ubiquitin-protein ligase HUWE1

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Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HUWE1

Cat.:

P2369Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HUWE1

Cat.:

P2369Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HUWE1

Protein for Rat E3 ubiquitin-protein ligase HUWE1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene."
Gu J. , Ren K. , Dubner R. , Iadarola M.J.
Brain Res. Mol. Brain Res.24:77-88(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
tissue: Brain.
2.

"UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation."
Gu J. , Dubner R. , Fornace A.J. Jr. , Iadarola M.J.
Oncogene11:2175-2178(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-219;MUTAGENESIS OF TYR-219
3.

"Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis."
Liu Z. , Miao D. , Xia Q. , Hermo L. , Wing S.S.
Dev. Dyn.236:2889-2898(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE

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