INSL3 CLIA Kit for Human(Homo sapiens) | EIAab.comINSL3 CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > INSL3(Gene name) > Human

INSL3 (Gene name),

Insulin-like 3 (Protein name ), INSL3_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

INSL3(RLF;RLNL);

Protein name:

Insulin-like 3;

Alternative:

Relaxin-like factor;Leydig insulin-like peptide(Ley-I-L);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Function:

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

131

Sequence:

50:

100:

131:

HRHHRAAATN | PARYCCLSGC | TQQDLLTLCP | Y

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000321724

SMR:

P51460

Pfam:

PF00049

String:

P51460

KEGG:

hsa:3640

UniGene:

Hs.37062

MIM:

146738

Uniprot:

P51460

FOR

ELISA Kit for Human Insulin-like 3

Cat.:

E0199h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Insulin-like 3

Cat.:

E0199r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Insulin-like 3

Cat.:

E0199d

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Insulin-like 3

Cat.:

E0199b

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Insulin-like 3

Cat.:

E0199p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Insulin-like 3

Cat.:

E0199m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Insulin-like 3

Cat.:

U0199h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Insulin-like 3

Cat.:

P0199Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Insulin-like 3

Cat.:

P0199Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Insulin-like 3

Cat.:

P0199Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Insulin-like 3

Protein for Human Insulin-like 3

Cat.:

R0199h

Price:

Please sign in first.

Packing:

1mg

Purity:

>90%

Protein for Human Insulin-like 3

R&D Technical Data

12% SDS-PAGE analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A human cDNA coding for the Leydig insulin-like peptide (Ley I-L)."
Burkhardt E. , Adham I.M. , Hobohm U. , Murphy D. , Sander C. , Engel W.
Hum. Genet.94:91-94(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-60
tissue: Testis.
2.

"Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3)."
Burkhardt E. , Adham I.M. , Brosig B. , Gastmann A. , Mattei M.-G. , Engel W.
Genomics20:13-19(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-60
3.

"The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast."
Tashima L.S. , Hieber A.D. , Greenwood F.C. , Bryant-Greenwood G.D.
J. Clin. Endocrinol. Metab.80:707-710(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
4.

"A novel human relaxin-like factor: evidence for the evolution of new hormonal functions?"
Lim H.N. , Oakenfull E.A. , Rajpert De Meyts E. , Skakkebaek N.E. , Hughes I.A. , Hawkins J.R. , Farr C.J.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-60
tissue: Testis.
6.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-60
tissue: Brain.
9.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-35
10.

"INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent."
Kumagai J. , Hsu S.Y. , Matsumi H. , Roh J.-S. , Fu P. , Wade J.D. , Bathgate R.A.D. , Hsueh A.J.W.
J. Biol. Chem.277:31283-31286(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LGR8
11.

"Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3."
Rosengren K.J. , Zhang S. , Lin F. , Daly N.L. , Scott D.J. , Hughes R.A. , Bathgate R.A. , Craik D.J. , Wade J.D.
J. Biol. Chem.281:28287-28295(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-55 AND 106-131;SUBUNIT;DISULFIDE BONDS
12.

"Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor."
Bullesbach E.E. , Hass M.A. , Jensen M.R. , Hansen D.F. , Kristensen S.M. , Schwabe C. , Led J.J.
Biochemistry47:13308-13317(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-55 AND 106-131;SUBUNIT;DISULFIDE BONDS
13.

"Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism."
Krausz C. , Quintana-Murci L. , Fellous M. , Siffroi J.P. , McElreavey K.
Mol. Hum. Reprod.6:298-302(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-60
14.

"Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism."
Tomboc M. , Lee P.A. , Mitwally M.F. , Schneck F.X. , Bellinger M. , Witchel S.F.
J. Clin. Endocrinol. Metab.85:4013-4018(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CRYPTO LEU-93;VARIANT ALA-60
15.

"A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism."
Koskimies P. , Virtanen H. , Lindstroem M. , Kaleva M. , Poutanen M. , Huhtaniemi I. , Toppari J.
Pediatr. Res.47:538-541(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-60
16.

"Novel insulin-like 3 (INSL3) gene mutation associated with human cryptorchidism."
Marin P. , Ferlin A. , Moro E. , Rossi A. , Bartoloni L. , Rossato M. , Foresta C.
Am. J. Med. Genet.103:348-349(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CRYPTO CYS-102;VARIANT ALA-60
17.

"Genetic analysis of the INSL3 gene in patients with maldescent of the testis."
Lim H.N. , Raipert-de Meyts E. , Skakkebaek N.E. , Hawkins J.R. , Hughes I.A.
Eur. J. Endocrinol.144:129-137(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-24; LEU-43; SER-49; ALA-60 AND HIS-102
18.

"Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism."
Marin P. , Ferlin A. , Moro E. , Garolla A. , Foresta C.
J. Endocrinol. Invest.24:RC13-RC15(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-60
19.

"Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population."
Takahashi I. , Takahashi T. , Komatsu M. , Matsuda J. , Takada G.
Pediatr. Int.43:256-258(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-60
20.

"A novel mutation of the insulin-like 3 gene in patients with cryptorchidism."
Canto P. , Escudero I. , Soederlund D. , Nishimura E. , Carranza-Lira S. , Gutierrez J. , Nava A. , Mendez J.P.
J. Hum. Genet.48:86-90(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CRYPTO LYS-110

Product Feedback Wall

* Email:
*Comments: