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Index > Protein center > Ireb2(Gene name) > Mouse
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  • Ireb2 (Gene name),
  • Iron-responsive element-binding protein 2 (Protein name ),  IREB2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ireb2(Irp2);
    Protein name:
    Iron-responsive element-binding protein 2(IRE-BP 2);
    Alternative:
    Iron regulatory protein 2(IRP2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.
    Function:
    RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    963
    Sequence:
    50:
    MDSPSAGYTF | EYLIETLNGN | SQKKFFNVPK | LGGTKYDILP | YSIRVLLEAA | 
    100:
    VRNCDGFLMK | KEDVMNILDW | KTKQSNVEVP | FFPARVVLQD | FTGIPAMVDF | 
    150:
    AAMREAVKTL | GGDPKKVHPA | CPTDLTVDHS | LQIDFSKCAI | QNAPNPGGGD | 
    200:
    LQKAGKLSPL | KVQSKKLPCR | GQTTCRGSCD | SGELSRNSGT | FSSQIENTPV | 
    250:
    LCPFHLQPVP | EPETVLKNQE | VEFGRNRERL | QFFKWSSGAF | KNVAVIPPGT | 
    300:
    GMAHQVNLEY | LSRVVFEETD | LLFPDSVVGT | DSHITMVNGL | GILGWGVGGI | 
    350:
    ETEAVMLGLP | VTLTLPEVVG | CELTGSSNAF | VTSIDIVLGI | TKHLRQVGVA | 
    400:
    GKFVEFFGSG | VSQLSIVDRT | TIANMCPEYG | AILSFFPVDN | VTLRHLEHTG | 
    450:
    FDKTKLESME | KYLKAVKLFR | NDENSSEPEY | SQVIQINLNS | IVASVSGPKR | 
    500:
    PQDRVAVTDM | KSDFQACLNE | KVGFKGFQVA | AEKQSDTVSV | RYDGSEYKLS | 
    550:
    HGSVVIAAVI | SCTNNCNPSV | MLAAGLLAKK | AVEIGLRVKP | YIRTSLSPGS | 
    600:
    GMVTHYLSSS | GVLPYLSKLG | FDIVGYGCST | CVGNTAPLSE | AVLNAVKQGD | 
    650:
    LVTCGVLSGN | KHFEGRLCDC | VRANYLASPP | LVVAYAIAGT | VNIDFQTEPL | 
    700:
    GTDSTGKEIY | LHDIWPSREE | VHQMEEEHVI | LSMFKTLKEK | VEMGNKRWNS | 
    750:
    LEAPDSVLFP | WDVKSTYIRC | PSFFDKLTKE | PAASQPIENA | HVLLYLGDSV | 
    800:
    TTDHISPAGS | IARSSAAAKY | LTNRGLTPRE | FNSYGARRGN | DAVMTRGTFA | 
    850:
    NIKLFNKFIG | KPAPKTIHFP | SGQTLDVFEA | AELYQKEGIP | LIILAGKKYG | 
    900:
    SGNSRDWAAK | GPYLLGVKAV | LAESYEKIHK | DHLIGIGIAP | LEFLPGENAD | 
    950:
    SLGLSGREVF | SLSFPEELFP | GITLNIKTST | GKEFSVIASF | ANDVEITLYK | 
    963:
    HGGLLNFVAR | KFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse IRE-BP 2
    Cat.:
    E13568h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse IRE-BP 2
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse IRE-BP 2
    Cat.:
    E13568r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse IRE-BP 2
    Cat.:
    E13568m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse IRE-BP 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse IRE-BP 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse IRE-BP 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse IRE-BP 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse IRE-BP 2
    Cat.:
    U13568h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse IRE-BP 2
    Cat.:
    U13568m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse IRE-BP 2
    Polyclonal Antibody for Mouse IRE-BP 2
    Polyclonal Antibody for Mouse IRE-BP 2
    Polyclonal Antibody for Mouse IRE-BP 2
    Polyclonal Antibody for Mouse IRE-BP 2
    Monoclonal Antibody for Mouse IRE-BP 2
    Monoclonal Antibody for Mouse IRE-BP 2
    Monoclonal Antibody for Mouse IRE-BP 2
    Monoclonal Antibody for Mouse IRE-BP 2
    Monoclonal Antibody for Mouse IRE-BP 2
    Protein for Mouse IRE-BP 2
    Protein for Mouse IRE-BP 2
    Protein for Mouse IRE-BP 2
    Protein for Mouse IRE-BP 2
    Protein for Mouse IRE-BP 2

    R&D Technical Data
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    3. 3.
      "Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line."
      Schalinske K.L. , Blemings K.P. , Steffen D.W. , Chen O.S. , Eisenstein R.S.
      Proc. Natl. Acad. Sci. U.S.A.94:10681-10686(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-214
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