Protein name:
Iron-responsive element-binding protein 2 (IRE-BP 2) ;
Alternative:
Iron regulatory protein 2 (IRP2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.
Function:
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MDSPSAGYTF | EYLIETLNGN | SQKKFFNVPK | LGGTKYDILP | YSIRVLLEAA |
100:
VRNCDGFLMK | KEDVMNILDW | KTKQSNVEVP | FFPARVVLQD | FTGIPAMVDF |
150:
AAMREAVKTL | GGDPKKVHPA | CPTDLTVDHS | LQIDFSKCAI | QNAPNPGGGD |
200:
LQKAGKLSPL | KVQSKKLPCR | GQTTCRGSCD | SGELSRNSGT | FSSQIENTPV |
250:
LCPFHLQPVP | EPETVLKNQE | VEFGRNRERL | QFFKWSSGAF | KNVAVIPPGT |
300:
GMAHQVNLEY | LSRVVFEETD | LLFPDSVVGT | DSHITMVNGL | GILGWGVGGI |
350:
ETEAVMLGLP | VTLTLPEVVG | CELTGSSNAF | VTSIDIVLGI | TKHLRQVGVA |
400:
GKFVEFFGSG | VSQLSIVDRT | TIANMCPEYG | AILSFFPVDN | VTLRHLEHTG |
450:
FDKTKLESME | KYLKAVKLFR | NDENSSEPEY | SQVIQINLNS | IVASVSGPKR |
500:
PQDRVAVTDM | KSDFQACLNE | KVGFKGFQVA | AEKQSDTVSV | RYDGSEYKLS |
550:
HGSVVIAAVI | SCTNNCNPSV | MLAAGLLAKK | AVEIGLRVKP | YIRTSLSPGS |
600:
GMVTHYLSSS | GVLPYLSKLG | FDIVGYGCST | CVGNTAPLSE | AVLNAVKQGD |
650:
LVTCGVLSGN | KHFEGRLCDC | VRANYLASPP | LVVAYAIAGT | VNIDFQTEPL |
700:
GTDSTGKEIY | LHDIWPSREE | VHQMEEEHVI | LSMFKTLKEK | VEMGNKRWNS |
750:
LEAPDSVLFP | WDVKSTYIRC | PSFFDKLTKE | PAASQPIENA | HVLLYLGDSV |
800:
TTDHISPAGS | IARSSAAAKY | LTNRGLTPRE | FNSYGARRGN | DAVMTRGTFA |
850:
NIKLFNKFIG | KPAPKTIHFP | SGQTLDVFEA | AELYQKEGIP | LIILAGKKYG |
900:
SGNSRDWAAK | GPYLLGVKAV | LAESYEKIHK | DHLIGIGIAP | LEFLPGENAD |
950:
SLGLSGREVF | SLSFPEELFP | GITLNIKTST | GKEFSVIASF | ANDVEITLYK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Rat
Mouse
Pig
ELISA Kit for Mouse IRE-BP 2
ELISA Kit for Mouse IRE-BP 2
ELISA Kit for Mouse IRE-BP 2
ELISA Kit for Mouse IRE-BP 2
ELISA Kit for Mouse IRE-BP 2
CLIA Kit for Mouse IRE-BP 2
CLIA Kit for Mouse IRE-BP 2
CLIA Kit for Mouse IRE-BP 2
CLIA Kit for Mouse IRE-BP 2
CLIA Kit for Mouse IRE-BP 2
Polyclonal Antibody for Mouse IRE-BP 2
Polyclonal Antibody for Mouse IRE-BP 2
Polyclonal Antibody for Mouse IRE-BP 2
Polyclonal Antibody for Mouse IRE-BP 2
Polyclonal Antibody for Mouse IRE-BP 2
Monoclonal Antibody for Mouse IRE-BP 2
Monoclonal Antibody for Mouse IRE-BP 2
Monoclonal Antibody for Mouse IRE-BP 2
Monoclonal Antibody for Mouse IRE-BP 2
Monoclonal Antibody for Mouse IRE-BP 2
Protein for Mouse IRE-BP 2
Protein for Mouse IRE-BP 2
Protein for Mouse IRE-BP 2
Protein for Mouse IRE-BP 2
Protein for Mouse IRE-BP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 140-214