Protein name:
Insulin receptor substrate 4 (IRS-4) ;
Alternative:
Phosphoprotein of 160 kDa (pp160) ;160 kDa phosphotyrosine protein (py160) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 (By similarity). Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH.
Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Protein Attributes:
50:
MASCSFTRDQ | ATRRLRGAAA | AAAAALAAVV | TTPLLSSGTP | TALIGTGSSC |
100:
PGAMWLSTAT | GSRSDSESEE | EDLPVGEEVC | KRGYLRKQKH | GHRRYFVLKL |
150:
ETADAPARLE | YYENARKFRH | SVRAAAAAAA | AAASGAAIPP | LIPPRRVITL |
200:
YQCFSVSQRA | DARYRHLIAL | FTQDEYFAMV | AENESEQESW | YLLLSRLILE |
250:
SKRRRCGTLG | AQPDGEPAAL | AAAAAAEPPF | YKDVWQVIVK | PRGLGHRKEL |
300:
SGVFRLCLTD | EEVVFVRLNT | EVASVVVQLL | SIRRCGHSEQ | YFFLEVGRST |
350:
VIGPGELWMQ | VDDCVVAQNM | HELFLEKMRA | LCADEYRARC | RSYSISIGAH |
400:
LLTLLSARRH | LGLVPLEPGG | WLRRSRFEQF | CHLRAIGDGE | DEMLFTRRFV |
450:
TPSEPVAHSR | RGRLHLPRGR | RSRRAVSVPA | SFFRRLAPSP | ARPRHPAEAP |
500:
NNGARLSSEV | SGSGSGNFGE | EGNPQGKEDQ | EGSGGDYMPM | NNWGSGNGRG |
550:
SGGGQGSNGQ | GSSSHSSGGN | QCSGEGQGSR | GGQGSNGQGS | GGNQCSRDGQ |
600:
GTAGGHGSGG | GQRPGGGHGS | GGGQGPGDGH | GSGGGKNSGG | GKGSGSGKGS |
650:
DGDGERGKSL | KKRSYFGKLT | QSKQQQMPPP | PPPPPPPPPA | GGTGGKGKSG |
700:
GRFRLYFCVD | RGATKECKEA | KEVKDAEIPE | GAARGPHRAR | AFDEDEDDPY |
750:
VPMRPGVATP | LVSSSDYMPM | APQNVSASKK | RHSRSPFEDS | RGYMMMFPRV |
800:
SPPPAPSPPK | APDTNKEDDS | KDNDSESDYM | FMAPGAGAIP | KNPRNPQGGS |
850:
SSKSWSSYFS | LPNPFRSSPL | GQNDNSEYVP | MLPGKFLGRG | LDKEVSYNWD |
900:
PKDAASKPSG | EGSFSKPGDG | GSPSKPSDHE | PPKNKAKRPN | RLSFITKGYK |
950:
IKPKPQKPTH | EQREADSSSD | YVNMDFTKRE | SNTPAPSTQG | LPDSWGIIAE |
1000:
PRQSAFSNYV | NVEFGVPFPN | PANDLSDLLR | AIPRANPLSL | DSARWPLPPL |
1050:
PLSATGSNAI | EEEGDYIEVI | FNSAMTPAMA | LADSAIRYDA | ETGRIYVVDP |
1100:
FSECCMDISL | SPSRCSEPPP | VARLLQEEEQ | ERRRPQSRSQ | SFFAAARAAV |
1150:
SAFPTDSLER | DLSPSSAPAV | ASAAEPTLAL | SQVVAAASAL | AAAPGIGAAA |
1200:
AAAGFDSASA | RWFQPVANAA | DAEAVRGAQD | VAGGSNPGAH | NPSANLARGD |
1250:
NQAGGAAAAA | AAPEPPPRSR | RVPRPPERED | SDNDDDTHVR | MDFARRDNQF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human IRS-4
ELISA Kit for Human IRS-4
Polyclonal Antibody for Human IRS-4
Polyclonal Antibody for Human IRS-4
Monoclonal Antibody for Human IRS-4
Monoclonal Antibody for Human IRS-4
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 100-117; 233-240; 613-618; 836-843 AND 844-852;PHOSPHORYLATION
tissue :
Kidney .
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[
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[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH GRB2 AND PIK3R1;PHOSPHORYLATION
5.
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Cited for : INTERACTION WITH CRK AND CRKL
6.
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Cited for : FUNCTION
7.
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Cited for : FUNCTION;INTERACTION WITH GRB2 AND PIK3R1
8.
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Cited for : INTERACTION WITH CRK;MUTAGENESIS OF TYR-700; TYR-717; TYR-743 AND TYR-779
9.
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Cited for : INTERACTION WITH NISCH
10.
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Cited for : FUNCTION;TISSUE SPECIFICITY
11.
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Cited for : PHOSPHORYLATION AT TYR-921;INTERACTION WITH SHC1; GRB2; PHOSPHOLIPASE C-GAMMA AND PHOSPHATIDYLINOSITOL 3-KINASE;IDENTIFICATION BY MASS SPECTROMETRY
12.
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Cited for : INTERACTION WITH PPP4C;INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
13.
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Cited for : INTERACTION WITH PTK6;IDENTIFICATION BY MASS SPECTROMETRY
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
15.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
"The consensus coding sequences of human breast and colorectal cancers."
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Science314:268-274(2006)
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[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] VAL-20; GLU-215 AND ARG-557