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Index > Protein center > ITGA1(Gene name) > Human
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  • ITGA1 (Gene name),
  • Integrin alpha-1 (Protein name ),  ITA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ITGA1;
    Protein name:
    Integrin alpha-1;
    Alternative:
    Laminin and collagen receptor;CD49 antigen-like family member A;VLA-1;
    CD:
    CD49a;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.
    Function:
    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1179
    Sequence:
    50:
    MAPRPRARPG | VAVACCWLLT | VVLRCCVSFN | VDVKNSMTFS | GPVEDMFGYT | 
    100:
    VQQYENEEGK | WVLIGSPLVG | QPKNRTGDVY | KCPVGRGESL | PCVKLDLPVN | 
    150:
    TSIPNVTEVK | ENMTFGSTLV | TNPNGGFLAC | GPLYAYRCGH | LHYTTGICSD | 
    200:
    VSPTFQVVNS | IAPVQECSTQ | LDIVIVLDGS | NSIYPWDSVT | AFLNDLLERM | 
    250:
    DIGPKQTQVG | IVQYGENVTH | EFNLNKYSST | EEVLVAAKKI | VQRGGRQTMT | 
    300:
    ALGIDTARKE | AFTEARGARR | GVKKVMVIVT | DGESHDNHRL | KKVIQDCEDE | 
    350:
    NIQRFSIAIL | GSYNRGNLST | EKFVEEIKSI | ASEPTEKHFF | NVSDELALVT | 
    400:
    IVKTLGERIF | ALEATADQSA | ASFEMEMSQT | GFSAHYSQDW | VMLGAVGAYD | 
    450:
    WNGTVVMQKA | SQIIIPRNTT | FNVESTKKNE | PLASYLGYTV | NSATASSGDV | 
    500:
    LYIAGQPRYN | HTGQVIIYRM | EDGNIKILQT | LSGEQIGSYF | GSILTTTDID | 
    550:
    KDSNTDILLV | GAPMYMGTEK | EEQGKVYVYA | LNQTRFEYQM | SLEPIKQTCC | 
    600:
    SSRQHNSCTT | ENKNEPCGAR | FGTAIAAVKD | LNLDGFNDIV | IGAPLEDDHG | 
    650:
    GAVYIYHGSG | KTIRKEYAQR | IPSGGDGKTL | KFFGQSIHGE | MDLNGDGLTD | 
    700:
    VTIGGLGGAA | LFWSRDVAVV | KVTMNFEPNK | VNIQKKNCHM | EGKETVCINA | 
    750:
    TVCFDVKLKS | KEDTIYEADL | QYRVTLDSLR | QISRSFFSGT | QERKVQRNIT | 
    800:
    VRKSECTKHS | FYMLDKHDFQ | DSVRITLDFN | LTDPENGPVL | DDSLPNSVHE | 
    850:
    YIPFAKDCGN | KEKCISDLSL | HVATTEKDLL | IVRSQNDKFN | VSLTVKNTKD | 
    900:
    SAYNTRTIVH | YSPNLVFSGI | EAIQKDSCES | NHNITCKVGY | PFLRRGEMVT | 
    950:
    FKILFQFNTS | YLMENVTIYL | SATSDSEEPP | ETLSDNVVNI | SIPVKYEVGL | 
    1000:
    QFYSSASEYH | ISIAANETVP | EVINSTEDIG | NEINIFYLIR | KSGSFPMPEL | 
    1050:
    KLSISFPNMT | SNGYPVLYPT | GLSSSENANC | RPHIFEDPFS | INSGKKMTTS | 
    1100:
    TDHLKRGTIL | DCNTCKFATI | TCNLTSSDIS | QVNVSLILWK | PTFIKSYFSS | 
    1150:
    LNLTIRGELR | SENASLVLSS | SNQKRELAIQ | ISKDGLPGRV | PLWVILLSAF | 
    1179:
    AGLLLLMLLI | LALWKIGFFK | RPLKKKMEK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Integrin alpha-1
    Cat.:
    E9158h
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    ELISA Kit for Human Integrin alpha-1
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    ELISA Kit for Human Integrin alpha-1
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    ELISA Kit for Human Integrin alpha-1
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    E9158c
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    Packing:
    96T
    CLIA Kit for Human Integrin alpha-1
    Cat.:
    U9158h
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    Packing:
    96T
    CLIA Kit for Human Integrin alpha-1
    Cat.:
    U9158r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Integrin alpha-1
    Cat.:
    U9158m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Integrin alpha-1
    Cat.:
    U9158c
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Integrin alpha-1
    Cat.:
    P9158Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Integrin alpha-1
    Polyclonal Antibody for Human Integrin alpha-1
    Cat.:
    P9158Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Integrin alpha-1
    Cat.:
    P9158Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Integrin alpha-1
    Monoclonal Antibody for Human Integrin alpha-1
    Monoclonal Antibody for Human Integrin alpha-1
    Monoclonal Antibody for Human Integrin alpha-1
    Protein for Human Integrin alpha-1
    Protein for Human Integrin alpha-1
    Protein for Human Integrin alpha-1
    Protein for Human Integrin alpha-1

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    Linearity
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    References
    1. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    2. 3.
      "Expression of native and truncated forms of the human integrin alpha 1 subunit."
      Briesewitz R. , Epstein M.R. , Marcantonio E.E.
      J. Biol. Chem.268:2989-2996(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1179
    3. 4.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-532
      tissue: Plasma.
    4. 5.
      "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."
      Mattila E. , Pellinen T. , Nevo J. , Vuoriluoto K. , Arjonen A. , Ivaska J.
      Nat. Cell Biol.7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EGFR SIGNALING;INTERACTION WITH PTPN2
    5. 6.
      "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
      Pellinen T. , Arjonen A. , Vuoriluoto K. , Kallio K. , Fransen J.A.M. , Ivaska J.
      J. Cell Biol.173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB21
    6. 7.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-105; ASN-217; ASN-341; ASN-418; ASN-460; ASN-532; ASN-780; ASN-840; ASN-966; ASN-974 AND ASN-1008
      tissue: Liver.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 9.
      "Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM."
      Rich R.L. , Deivanayagam C.C. , Owens R.T. , Carson M. , Hook A. , Moore D. , Symersky J. , Yang V.W. , Narayana S.V. , Hook M.
      J. Biol. Chem.274:24906-24913(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 168-359
    9. 10.
      "Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1."
      Nymalm Y. , Puranen J.S. , Nyholm T.K. , Kapyla J. , Kidron H. , Pentikainen O.T. , Airenne T.T. , Heino J. , Slotte J.P. , Johnson M.S. , Salminen T.A.
      J. Biol. Chem.279:7962-7970(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 166-356
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