Protein name:
Integrin alpha-IIb ;
Alternative:
Platelet membrane glycoprotein IIb ;GPalpha IIb (GPIIb) ;
CD:
CD41 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181.
Function:
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MARASCAWHS | LWLLQWTPLF | LGPSAVPPVW | ALNLDSEKFS | VYAGPNGSHF |
100:
GFSVDFHKDK | HGSVSIVVGA | PRALNASQEE | TGAVFLCPWK | ANGGKCNPLL |
150:
FDLRDETRNL | GFQIFQTFKT | GQGLGASVVS | WNDVIVACAP | WQHWNVLEKR |
200:
DEAEKTPVGG | CFLAQLQSGG | RAEYSPCRAN | TMSSVYAESF | RGDKRYCEAG |
250:
FSLAVTQAGE | LVLGAPGGYF | FLGLLARVPI | ENIISSYRPG | TLLWHVSNQR |
300:
FTYDNSNPVF | FDGYRGYSVA | VGEFDGDPST | TEYVSGAPTW | SWTLGAVEIL |
350:
DSYYQPLHRL | HGEQMASYFG | HSVAVTDVNG | DGRHDLLVGA | PLYMESRADR |
400:
KLAEVGRVYL | FLQPKGPQAL | STPTLLLTGT | QLYGRFGSAI | APLGDLNRDG |
450:
YNDIAVAAPY | GGPSGQGQVL | IFLGQSEGLS | PRPSQVLDSP | FPTGSGFGFS |
500:
LRGAVDIDDN | GYPDLIVGAY | GASKVAVYRA | QPVVMATVQL | MVQDSLNPTL |
550:
KNCVLDQTKT | PVSCFNIQMC | VGATGHNIPQ | KLHLKAELQL | DLQKPRQGRR |
600:
VLLLASQQAS | LTLSLDLGGR | DKPICHTTGA | FLRDEADFRD | KLSPIVLSLN |
650:
VSLPPEETGG | APAVVLHGET | HVQEQTRIIL | DCGEDDLCVP | QLRLTATAGD |
700:
SPLLIGADNV | LELKIEAAND | GEGAYEAELA | VHLPPGAHYM | RALSNIEGFE |
750:
RLVCTQKKEN | ESRVALCELG | NPMKKDTRIG | ITMLVSVENL | EEAGESVSFQ |
800:
LQVRSKNSQN | PNSKVVMLPV | AIQAEATVEL | RGNSFPASLV | VAAEEGDREQ |
850:
EDLDRWVSRL | EHTYELHNIG | PGTVNGLRLL | IHIPGQSQPS | DLLYILDVQP |
900:
QGGLLCSTQP | SPKVDWKLST | PSPSSIRPVH | HQRERRQAFL | QGPKPGQQDP |
950:
VLVSCDGSAS | CTVVECELRE | MVRGQRAMVT | VQVMLGLSSL | RQRPQEQFVL |
1000:
QSHAWFNVSS | LPYSVPVVSL | PSGQARVQTQ | LLRALEERAI | PVWWVLVGVL |
1033:
GGLLLLTLLV | LAMWKAGFFK | RNRPPLEEDE | EEE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Integrin alpha-IIb
ELISA Kit for Mouse Integrin alpha-IIb
CLIA Kit for Mouse Integrin alpha-IIb
CLIA Kit for Mouse Integrin alpha-IIb
Polyclonal Antibody for Mouse Integrin alpha-IIb
Polyclonal Antibody for Mouse Integrin alpha-IIb
Monoclonal Antibody for Mouse Integrin alpha-IIb
Monoclonal Antibody for Mouse Integrin alpha-IIb
Protein for Mouse Integrin alpha-IIb
Protein for Mouse Integrin alpha-IIb
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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