Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > Itga2b(Gene name) > Mouse
  • Add your favorite
  • Itga2b (Gene name),
  • Integrin alpha-IIb (Protein name ),  ITA2B_MOUSE from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    Itga2b;
    Protein name:
    Integrin alpha-IIb;
    Alternative:
    Platelet membrane glycoprotein IIb;GPalpha IIb(GPIIb);
    CD:
    CD41;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181.
    Function:
    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1033
    Sequence:
    50:
    MARASCAWHS | LWLLQWTPLF | LGPSAVPPVW | ALNLDSEKFS | VYAGPNGSHF | 
    100:
    GFSVDFHKDK | HGSVSIVVGA | PRALNASQEE | TGAVFLCPWK | ANGGKCNPLL | 
    150:
    FDLRDETRNL | GFQIFQTFKT | GQGLGASVVS | WNDVIVACAP | WQHWNVLEKR | 
    200:
    DEAEKTPVGG | CFLAQLQSGG | RAEYSPCRAN | TMSSVYAESF | RGDKRYCEAG | 
    250:
    FSLAVTQAGE | LVLGAPGGYF | FLGLLARVPI | ENIISSYRPG | TLLWHVSNQR | 
    300:
    FTYDNSNPVF | FDGYRGYSVA | VGEFDGDPST | TEYVSGAPTW | SWTLGAVEIL | 
    350:
    DSYYQPLHRL | HGEQMASYFG | HSVAVTDVNG | DGRHDLLVGA | PLYMESRADR | 
    400:
    KLAEVGRVYL | FLQPKGPQAL | STPTLLLTGT | QLYGRFGSAI | APLGDLNRDG | 
    450:
    YNDIAVAAPY | GGPSGQGQVL | IFLGQSEGLS | PRPSQVLDSP | FPTGSGFGFS | 
    500:
    LRGAVDIDDN | GYPDLIVGAY | GASKVAVYRA | QPVVMATVQL | MVQDSLNPTL | 
    550:
    KNCVLDQTKT | PVSCFNIQMC | VGATGHNIPQ | KLHLKAELQL | DLQKPRQGRR | 
    600:
    VLLLASQQAS | LTLSLDLGGR | DKPICHTTGA | FLRDEADFRD | KLSPIVLSLN | 
    650:
    VSLPPEETGG | APAVVLHGET | HVQEQTRIIL | DCGEDDLCVP | QLRLTATAGD | 
    700:
    SPLLIGADNV | LELKIEAAND | GEGAYEAELA | VHLPPGAHYM | RALSNIEGFE | 
    750:
    RLVCTQKKEN | ESRVALCELG | NPMKKDTRIG | ITMLVSVENL | EEAGESVSFQ | 
    800:
    LQVRSKNSQN | PNSKVVMLPV | AIQAEATVEL | RGNSFPASLV | VAAEEGDREQ | 
    850:
    EDLDRWVSRL | EHTYELHNIG | PGTVNGLRLL | IHIPGQSQPS | DLLYILDVQP | 
    900:
    QGGLLCSTQP | SPKVDWKLST | PSPSSIRPVH | HQRERRQAFL | QGPKPGQQDP | 
    950:
    VLVSCDGSAS | CTVVECELRE | MVRGQRAMVT | VQVMLGLSSL | RQRPQEQFVL | 
    1000:
    QSHAWFNVSS | LPYSVPVVSL | PSGQARVQTQ | LLRALEERAI | PVWWVLVGVL | 
    1033:
    GGLLLLTLLV | LAMWKAGFFK | RNRPPLEEDE | EEE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Integrin alpha-IIb
    Cat.:
    E0614m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Integrin alpha-IIb
    Cat.:
    E0614h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Integrin alpha-IIb
    Cat.:
    U0614h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Integrin alpha-IIb
    Cat.:
    U0614m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Integrin alpha-IIb
    Cat.:
    P0614Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Integrin alpha-IIb
    Cat.:
    P0614Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Integrin alpha-IIb
    Monoclonal Antibody for Mouse Integrin alpha-IIb
    Protein for Mouse Integrin alpha-IIb
    Protein for Mouse Integrin alpha-IIb

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Characterization of the murine platelet alphaIIb gene and encoded cDNA."
      Thornton M.A. , Poncz M.
      Blood94:3947-3950(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Heart.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "Identification of the alpha IIb beta 3 integrin in murine tumor cells."
      Chen Y.Q. , Gao X. , Timar J. , Tang D. , Grossi I.M. , Chelladurai M. , Kunicki T.J. , Fligiel S.E. , Taylor J.D. , Honn K.V.
      J. Biol. Chem.267:17314-17320(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 805-865
    6. 6.
      Rout U.K. , Armant D.R.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 790-1022
    7. 7.
      "Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3."
      Puzon-McLaughlin W. , Kamata T. , Takada Y.
      J. Biol. Chem.275:7795-7802(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-484
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter