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Index > Protein center > Lama2(Gene name) > Mouse
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  • Lama2 (Gene name),
  • Laminin subunit alpha-2 (Protein name ),  LAMA2_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Lama2;
    Protein name:
    Laminin subunit alpha-2;
    Alternative:
    Laminin-12 subunit alpha;Laminin M chain;Laminin-4 subunit alpha;Laminin-2 subunit alpha;Merosin heavy chain;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2.
    Function:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane Major component.
    Protein Attributes:
    Sequence length:
    3106
    Sequence:
    50:
    MPAATAGILL | LLLLGTLEGS | QTQRRQSQAH | QQRGLFPAVL | NLASNALITT | 
    100:
    NATCGEKGPE | MYCKLVEHVP | GQPVRNPQCR | ICNQNSSNPY | QRHPITNAID | 
    150:
    GKNTWWQSPS | IKNGVEYHYV | TITLDLQQVF | QIAYVIVKAA | NSPRPGNWIL | 
    200:
    ERSLDDVEYK | PWQYHAVTDT | ECLTLYNIYP | RTGPPSYAKD | DEVICTSFYS | 
    250:
    KIHPLENGEI | HISLINGRPS | ADDPSPELLE | FTSARYIRLR | FQRIRTLNAD | 
    300:
    LMMFAHKDPR | EIDPIVTRRY | YYSVKDISVG | GMCICYGHAR | ACPLDPATNK | 
    350:
    SRCECEHNTC | GESCDRCCPG | FHQKPWRAGT | FLTKSECEAC | NCHGKAEECY | 
    400:
    YDETVASRNL | SLNIHGKYIG | GGVCINCTHN | TAGINCETCV | DGFFRPKGVS | 
    450:
    PNYPRPCQPC | HCDPTGSLSE | VCVKDEKYAQ | RGLKPGSCHC | KTGFGGVNCD | 
    500:
    RCVRGYHGYP | DCQPCNCSGL | GSTNEDPCVG | PCSCKENVEG | EDCSRCKSGF | 
    550:
    FNLQEDNQKG | CEECFCSGVS | NRCQSSYWTY | GNIQDMRGWY | LTDLSGRIRM | 
    600:
    APQLDNPDSP | QQISISNSEA | RKSLLDGYYW | SAPPPYLGNR | LPAVGGQLSF | 
    650:
    TISYDLEEEE | DDTEKLLQLM | IIFEGNDLRI | STAYKEVYLE | PSEEHVEEVS | 
    700:
    LKEEAFTIHG | TNLPVTRKDF | MIVLTNLGEI | LIQITYNLGM | DAIFRLSSVN | 
    750:
    LESPVPYPTD | RRIATDVEVC | QCPPGYSGSS | CETCWPRHRR | VNGTIFGGIC | 
    800:
    EPCQCFAHAE | ACDDITGECL | NCKDHTGGPY | CNECLPGFYG | DPTRGSPEDC | 
    850:
    QPCACPLNIP | SNNFSPTCHL | DRSLGLICDE | CPIGYTGPRC | ERCAEGYFGQ | 
    900:
    PSVPGGSCQP | CQCNDNLDYS | IPGSCDSLSG | SCLICKPGTT | GRYCELCADG | 
    950:
    YFGDAVNTKN | CQPCRCDING | SFSEDCHTRT | GQCECRPNVQ | GRHCDECKPE | 
    1000:
    TFGLQLGRGC | LPCNCNSFGS | KSFDCEASGQ | CWCQPGVAGK | KCDRCAHGYF | 
    1050:
    NFQEGGCIAC | DCSHLGNNCD | PKTGQCICPP | NTTGEKCSEC | LPNTWGHSIV | 
    1100:
    TGCKVCNCST | VGSLASQCNV | NTGQCSCHPK | FSGMKCSECS | RGHWNYPLCT | 
    1150:
    LCDCFLPGTD | ATTCDLETRK | CSCSDQTGQC | SCKVNVEGVH | CDRCRPGKFG | 
    1200:
    LDAKNPLGCS | SCYCFGVTSQ | CSEAKGLIRT | WVTLSDEQTI | LPLVDEALQH | 
    1250:
    TTTKGIAFQK | PEIVAKMDEV | RQELHLEPFY | WKLPQQFEGK | KLMAYGGKLK | 
    1300:
    YAIYFEARDE | TGFATYKPQV | IIRGGTPTHA | RIITRHMAAP | LIGQLTRHEI | 
    1350:
    EMTEKEWKYY | GDDPRISRTV | TREDFLDILY | DIHYILIKAT | YGNVVRQSRI | 
    1400:
    SEISMEVAEP | GHVLAGSPPA | HLIERCDCPP | GYSGLSCETC | APGFYRLRSE | 
    1450:
    PGGRTPGPTL | GTCVPCQCNG | HSSQCDPETS | VCQNCQHHTA | GDFCERCALG | 
    1500:
    YYGIVRGLPN | DCQPCACPLI | SPSNNFSPSC | VLEGLEDYRC | TACPRGYEGQ | 
    1550:
    YCERCAPGYT | GSPSSPGGSC | QECECDPYGS | LPVPCDRVTG | LCTCRPGATG | 
    1600:
    RKCDGCEHWH | AREGAECVFC | GDECTGLLLG | DLARLEQMTM | NINLTGPLPA | 
    1650:
    PYKILYGLEN | TTQELKHLLS | PQRAPERLIQ | LAEGNVNTLV | METNELLTRA | 
    1700:
    TKVTADGEQT | GQDAERTNSR | AESLEEFIKG | LVQDAEAINE | KAVKLNETLG | 
    1750:
    NQDKTAERNL | EELQKEIDRM | LKELRSKDLQ | TQKEVAEDEL | VAAEGLLKRV | 
    1800:
    NKLFGEPRAQ | NEDMEKDLQQ | KLAEYKNKLD | DAWDLLREAT | DKTRDANRLS | 
    1850:
    AANQKNMTIL | ETKKEAIEGS | KRQIENTLKE | GNDILDEANQ | LLGEINSVID | 
    1900:
    YVDDIKTKLP | PMSEELSDKI | DDLAQEIKDR | RLAEKVFQAE | SHAAQLNDSS | 
    1950:
    AVLDGILDEA | KNISFNATAA | FRAYSNIKDY | IDEAEKVARE | AKELAQGATK | 
    2000:
    LATSPQGLLK | EDAKGSLQKS | FRILNEAKKL | ANDVKGNHND | LNDLKTRLET | 
    2050:
    ADLRNSGLLG | ALNDTMDKLS | AITNDTAAKL | QAVKEKAREA | NDTAKAVLAQ | 
    2100:
    VKDLHQNLDG | LKQNYNKLAD | SVAKTNAVVK | DPSKNKIIAD | AGTSVRNLEQ | 
    2150:
    EADRLIDKLK | PIKELEDNLK | KNISEIKELI | NQARKQANSI | KVSVSSGGDC | 
    2200:
    VRTYRPEIKK | GSYNNIVVHV | KTAVADNLLF | YLGSAKFIDF | LAIEMRKGKV | 
    2250:
    SFLWIVGSGV | GRVGFPDLTI | DDSYWYRIEA | SRTGRNGSIS | VRALDGPKAS | 
    2300:
    MVPSTYHSVS | PPGYTILDVD | ANAMLFVGGL | TGKIKKADAV | RVITFTGCMG | 
    2350:
    ETYFDNKPIG | LWNFREKEGD | CKGCTVSPQV | EDSEGTIQFD | GEGYALVSRP | 
    2400:
    IRWYPNISTV | MFKFRTFSSS | ALLMYLATRD | LKDFMSVELS | DGHVKVSYDL | 
    2450:
    GSGMTSVVSN | QNHNDGKWKA | FTLSRIQKQA | NISIVDIDSN | QEENVATSSS | 
    2500:
    GNNFGLDLKA | DDKIYFGGLP | TLRNLSMKAR | PEVNVKKYSG | CLKDIEISRT | 
    2550:
    PYNILSSPDY | VGVTKGCSLE | NVNTVSFPKP | GFVELAAVSI | DVGTEINLSF | 
    2600:
    STRNESGIIL | LGSGGTLTPP | RRKRRQTTQA | YYAIFLNKGR | LEVHLSSGTR | 
    2650:
    TMRKIVIKPE | PNLFHDGREH | SVHVERTRGI | FTVQIDEDRR | HIQNLTEEQP | 
    2700:
    IEVKKLFVGG | APPEFQPSPL | RNIPAFQGCV | WNLVINSIPM | DFAQPIAFKN | 
    2750:
    ADIGRCTYQK | PREDESEAVP | AEVIVQPQSV | PTPAFPFPVP | TMVHGPCVAE | 
    2800:
    SEPALLTGSK | QFGLSRNSHI | AIVFDDTKVK | NRLTIELEVR | TEAESGLLFY | 
    2850:
    MGRINHADFG | TVQLRNGFPF | FSYDLGSGST | RTMIPTKIND | GQWHKIKIVR | 
    2900:
    VKQEGILYVD | DASSQTISPK | KADILDVGGI | LYVGGLPINY | TTRRIGPVTY | 
    2950:
    SLDGCVRNLH | MEQAPVDLDQ | PTSSFHVGTC | FANAESGTYF | DGTGFGKAVG | 
    3000:
    GFIVGLDLLV | EFEFRTTRPT | GVLLGISSQK | MDGMGIEMID | EKLMFHVDNG | 
    3050:
    AGRFTAIYDA | EIPGHMCNGQ | WYKVTAKKIK | NRLELVVDGN | QVDAQSPNSA | 
    3100:
    STSADTNDPV | FVGGFPGGLN | QFGLTTNIRF | RGCIRSLKLT | KGTANRWRLI | 
    3106:
    LPRPWN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Laminin subunit alpha-2
    Cat.:
    E9489h
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    Packing:
    96T
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    ELISA Kit for Mouse Laminin subunit alpha-2
    Cat.:
    E9489m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Laminin subunit alpha-2
    Cat.:
    U9489m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Laminin subunit alpha-2
    Cat.:
    U9489h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Laminin subunit alpha-2
    Cat.:
    P9489Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Laminin subunit alpha-2
    Cat.:
    P9489Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Laminin subunit alpha-2
    Monoclonal Antibody for Mouse Laminin subunit alpha-2
    Protein for Mouse Laminin subunit alpha-2
    Protein for Mouse Laminin subunit alpha-2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and expression of laminin alpha 2 chain (M-chain) in the mouse."
      Bernier S.M. , Utani A. , Sugiyama S. , Doi T. , Polistina C. , Yamada Y.
      Matrix Biol.14:447-455(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: FVB/N.
      tissue: Embryo.
      tissue: Heart.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "Expression of merosin in the thymus and its interaction with thymocytes."
      Chang A.C. , Wadsworth S. , Coligan J.E.
      J. Immunol.151:1789-1801(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2162-2279
      strain: C57BL/6.
      tissue: Thymus.
    4. 4.
      "Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene."
      Xu H. , Wu X.R. , Wewer U.M. , Engvall E.
      Nat. Genet.8:297-302(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-281
    5. 5.
      "Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains."
      Garbe J.H. , Gohring W. , Mann K. , Timpl R. , Sasaki T.
      Biochem. J.362:213-221(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-25
    6. 6.
      "Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins."
      Talts J.F. , Andac Z. , Goehring W. , Brancaccio A. , Timpl R.
      EMBO J.18:863-870(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN1; FBLN2 AND NID2
    7. 7.
      "The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin."
      Hohenester E. , Tisi D. , Talts J.F. , Timpl R.
      Mol. Cell4:783-792(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 2932-3106
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