MAF CLIA Kit for Human(Homo sapiens) | EIAab.comMAF CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > MAF(Gene name) > Human

MAF (Gene name),

Transcription factor Maf (Protein name ), MAF_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

MAF;

Protein name:

Transcription factor Maf;

Alternative:

V-maf musculoaponeurotic fibrosarcoma oncogene homolog;Proto-oncogene c-Maf;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction take place weakly in normal T cells and increases in T cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complexe formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1.

Function:

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant reponse element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

373

Sequence:

50:

100:

150:

200:

250:

300:

350:

373:

LVSSGFRENG | SSSDNPSSPE | FFM

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

hsa:4094

String:

O75444

SMR:

O75444

STRING:

9606.ENSP00000327048

UniGene:

Hs.134859

MIM:

177075

Pfam:

PF03131

Uniprot:

O75444

FOR

ELISA Kit for Human Transcription factor Maf

Cat.:

E1179h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Transcription factor Maf

Cat.:

E1179r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Transcription factor Maf

Cat.:

E1179m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Transcription factor Maf

Cat.:

E1179b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Transcription factor Maf

Cat.:

E1179c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transcription factor Maf

Cat.:

U1179m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transcription factor Maf

Cat.:

U1179b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transcription factor Maf

Cat.:

U1179h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Transcription factor Maf

Cat.:

U1179c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transcription factor Maf

Cat.:

U1179r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Transcription factor Maf

Cat.:

P1179Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Transcription factor Maf

Cat.:

P1179Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Transcription factor Maf

Cat.:

P1179Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Transcription factor Maf

Protein for Human Transcription factor Maf

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma."
Chesi M. , Bergsagel P.L. , Shonukan O.O. , Martelli M.L. , Brents L.A. , Chen T. , Schrock E. , Ried T. , Kuehl W.M.
Blood91:4457-4463(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);ALTERNATIVE SPLICING
2.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
4.

"c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction."
Dhakshinamoorthy S. , Jaiswal A.K.
Oncogene21:5301-5312(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INDUCTION;DNA-BINDING
5.

"Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma."
Hurt E.M. , Wiestner A. , Rosenwald A. , Shaffer A.L. , Campo E. , Grogan T. , Bergsagel P.L. , Kuehl W.M. , Staudt L.M.
Cancer Cell5:191-199(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer."
Watson J.E. , Doggett N.A. , Albertson D.G. , Andaya A. , Chinnaiyan A. , van Dekken H. , Ginzinger D. , Haqq C. , James K. , Kamkar S. , Kowbel D. , Pinkel D. , Schmitt L. , Simko J.P. , Volik S. , Weinberg V.K. , Paris P.L. , Collins C.
Oncogene23:3487-3494(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"MafA transcription factor is phosphorylated by p38 MAP kinase."
Sii-Felice K. , Pouponnot C. , Gillet S. , Lecoin L. , Girault J.-A. , Eychene A. , Felder-Schmittbuhl M.-P.
FEBS Lett.579:3547-3554(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
8.

"A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin."
Mao X. , Stewart A.K. , Hurren R. , Datti A. , Zhu X. , Zhu Y. , Shi C. , Lee K. , Tiedemann R. , Eberhard Y. , Trudel S. , Liang S. , Corey S.J. , Gillis L.C. , Barber D.L. , Wrana J.L. , Ezzat S. , Schimmer A.D.
Blood110:4047-4054(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
9.

"Cell context reveals a dual role for Maf in oncogenesis."
Pouponnot C. , Sii-Felice K. , Hmitou I. , Rocques N. , Lecoin L. , Druillennec S. , Felder-Schmittbuhl M.-P. , Eychene A.
Oncogene25:1299-1310(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element."
Mahoney K.M. , Petrovic N. , Schacke W. , Shapiro L.H.
Gene403:178-187(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"GSK-3-mediated phosphorylation enhances Maf-transforming activity."
Rocques N. , Abou Zeid N. , Sii-Felice K. , Lecoin L. , Felder-Schmittbuhl M.-P. , Eychene A. , Pouponnot C.
Mol. Cell28:584-597(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
12.

"A new MAFia in cancer."
Eychene A. , Rocques N. , Pouponnot C.
Nat. Rev. Cancer8:683-693(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;FUNCTION
13.

"Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma."
Jamieson R.V. , Perveen R. , Kerr B. , Carette M. , Yardley J. , Heon E. , Wirth M.G. , van Heyningen V. , Donnai D. , Munier F. , Black G.C.
Hum. Mol. Genet.11:33-42(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT21 PRO-288
14.

"A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant 'cerulean cataract' in an Indian family."
Vanita V. , Singh D. , Robinson P.N. , Sperling K. , Singh J.R.
Am. J. Med. Genet. A140:558-566(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT21 ARG-297

Product Feedback Wall

* Email:
*Comments: