Gene name:
MBTPS1 (KIAA0091;S1P;SKI1) ;
Protein name:
Membrane-bound transcription factor site-1 protease ;
Alternative:
Subtilisin/kexin-isozyme 1 (SKI-1) ;Endopeptidase S1P ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Golgi apparatus membrane
Single-pass type I membrane protein
May sort to other organelles, including lysosomal and/or endosomal compartments.
Protein Attributes:
50:
MKLVNIWLLL | LVVLLCGKKH | LGDRLEKKSF | EKAPCPGCSH | LTLKVEFSST |
100:
VVEYEYIVAF | NGYFTAKARN | SFISSALKSS | EVDNWRIIPR | NNPSSDYPSD |
150:
FEVIQIKEKQ | KAGLLTLEDH | PNIKRVTPQR | KVFRSLKYAE | SDPTVPCNET |
200:
RWSQKWQSSR | PLRRASLSLG | SGFWHATGRH | SSRRLLRAIP | RQVAQTLQAD |
250:
VLWQMGYTGA | NVRVAVFDTG | LSEKHPHFKN | VKERTNWTNE | RTLDDGLGHG |
300:
TFVAGVIASM | RECQGFAPDA | ELHIFRVFTN | NQVSYTSWFL | DAFNYAILKK |
350:
IDVLNLSIGG | PDFMDHPFVD | KVWELTANNV | IMVSAIGNDG | PLYGTLNNPA |
400:
DQMDVIGVGG | IDFEDNIARF | SSRGMTTWEL | PGGYGRMKPD | IVTYGAGVRG |
450:
SGVKGGCRAL | SGTSVASPVV | AGAVTLLVST | VQKRELVNPA | SMKQALIASA |
500:
RRLPGVNMFE | QGHGKLDLLR | AYQILNSYKP | QASLSPSYID | LTECPYMWPY |
550:
CSQPIYYGGM | PTVVNVTILN | GMGVTGRIVD | KPDWQPYLPQ | NGDNIEVAFS |
600:
YSSVLWPWSG | YLAISISVTK | KAASWEGIAQ | GHVMITVASP | AETESKNGAE |
650:
QTSTVKLPIK | VKIIPTPPRS | KRVLWDQYHN | LRYPPGYFPR | DNLRMKNDPL |
700:
DWNGDHIHTN | FRDMYQHLRS | MGYFVEVLGA | PFTCFDASQY | GTLLMVDSEE |
750:
EYFPEEIAKL | RRDVDNGLSL | VIFSDWYNTS | VMRKVKFYDE | NTRQWWMPDT |
800:
GGANIPALNE | LLSVWNMGFS | DGLYEGEFTL | ANHDMYYASG | CSIAKFPEDG |
850:
VVITQTFKDQ | GLEVLKQETA | VVENVPILGL | YQIPAEGGGR | IVLYGDSNCL |
900:
DDSHRQKDCF | WLLDALLQYT | SYGVTPPSLS | HSGNRQRPPS | GAGSVTPERM |
950:
EGNHLHRYSK | VLEAHLGDPK | PRPLPACPRL | SWAKPQPLNE | TAPSNLWKHQ |
1000:
KLLSIDLDKV | VLPNFRSNRP | QVRPLSPGES | GAWDIPGGIM | PGRYNQEVGQ |
1050:
TIPVFAFLGA | MVVLAFFVVQ | INKAKSRPKR | RKPRVKRPQL | MQQVHPPKTP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Membrane-bound transcription factor site-1 protease
ELISA Kit for Human Membrane-bound transcription factor site-1 protease
ELISA Kit for Human Membrane-bound transcription factor site-1 protease
CLIA Kit for Human Membrane-bound transcription factor site-1 protease
CLIA Kit for Human Membrane-bound transcription factor site-1 protease
CLIA Kit for Human Membrane-bound transcription factor site-1 protease
Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
Protein for Human Membrane-bound transcription factor site-1 protease
Protein for Human Membrane-bound transcription factor site-1 protease
Protein for Human Membrane-bound transcription factor site-1 protease
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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