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Index > Protein center > MBTPS1(Gene name) > Human
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  • MBTPS1 (Gene name),
  • Membrane-bound transcription factor site-1 protease (Protein name ),  MBTP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MBTPS1(KIAA0091;S1P;SKI1);
    Protein name:
    Membrane-bound transcription factor site-1 protease;
    Alternative:
    Subtilisin/kexin-isozyme 1(SKI-1);Endopeptidase S1P;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein May sort to other organelles, including lysosomal and/or endosomal compartments.
    Protein Attributes:
    Sequence length:
    1052
    Sequence:
    50:
    MKLVNIWLLL | LVVLLCGKKH | LGDRLEKKSF | EKAPCPGCSH | LTLKVEFSST | 
    100:
    VVEYEYIVAF | NGYFTAKARN | SFISSALKSS | EVDNWRIIPR | NNPSSDYPSD | 
    150:
    FEVIQIKEKQ | KAGLLTLEDH | PNIKRVTPQR | KVFRSLKYAE | SDPTVPCNET | 
    200:
    RWSQKWQSSR | PLRRASLSLG | SGFWHATGRH | SSRRLLRAIP | RQVAQTLQAD | 
    250:
    VLWQMGYTGA | NVRVAVFDTG | LSEKHPHFKN | VKERTNWTNE | RTLDDGLGHG | 
    300:
    TFVAGVIASM | RECQGFAPDA | ELHIFRVFTN | NQVSYTSWFL | DAFNYAILKK | 
    350:
    IDVLNLSIGG | PDFMDHPFVD | KVWELTANNV | IMVSAIGNDG | PLYGTLNNPA | 
    400:
    DQMDVIGVGG | IDFEDNIARF | SSRGMTTWEL | PGGYGRMKPD | IVTYGAGVRG | 
    450:
    SGVKGGCRAL | SGTSVASPVV | AGAVTLLVST | VQKRELVNPA | SMKQALIASA | 
    500:
    RRLPGVNMFE | QGHGKLDLLR | AYQILNSYKP | QASLSPSYID | LTECPYMWPY | 
    550:
    CSQPIYYGGM | PTVVNVTILN | GMGVTGRIVD | KPDWQPYLPQ | NGDNIEVAFS | 
    600:
    YSSVLWPWSG | YLAISISVTK | KAASWEGIAQ | GHVMITVASP | AETESKNGAE | 
    650:
    QTSTVKLPIK | VKIIPTPPRS | KRVLWDQYHN | LRYPPGYFPR | DNLRMKNDPL | 
    700:
    DWNGDHIHTN | FRDMYQHLRS | MGYFVEVLGA | PFTCFDASQY | GTLLMVDSEE | 
    750:
    EYFPEEIAKL | RRDVDNGLSL | VIFSDWYNTS | VMRKVKFYDE | NTRQWWMPDT | 
    800:
    GGANIPALNE | LLSVWNMGFS | DGLYEGEFTL | ANHDMYYASG | CSIAKFPEDG | 
    850:
    VVITQTFKDQ | GLEVLKQETA | VVENVPILGL | YQIPAEGGGR | IVLYGDSNCL | 
    900:
    DDSHRQKDCF | WLLDALLQYT | SYGVTPPSLS | HSGNRQRPPS | GAGSVTPERM | 
    950:
    EGNHLHRYSK | VLEAHLGDPK | PRPLPACPRL | SWAKPQPLNE | TAPSNLWKHQ | 
    1000:
    KLLSIDLDKV | VLPNFRSNRP | QVRPLSPGES | GAWDIPGGIM | PGRYNQEVGQ | 
    1050:
    TIPVFAFLGA | MVVLAFFVVQ | INKAKSRPKR | RKPRVKRPQL | MQQVHPPKTP | 
    1052:
    SV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Human Membrane-bound transcription factor site-1 protease
    Protein for Human Membrane-bound transcription factor site-1 protease
    Protein for Human Membrane-bound transcription factor site-1 protease
    Protein for Human Membrane-bound transcription factor site-1 protease

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene."
      Nakajima T. , Iwaki K. , Kodama T. , Inazawa J. , Emi M.
      J. Hum. Genet.45:212-217(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Myeloid.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    4. 4.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1052
      tissue: Testis.
    7. 7.
      "Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment."
      Toure B.B. , Munzer J.S. , Basak A. , Benjannet S. , Rochemont J. , Lazure C. , Chretien M. , Seidah N.G.
      J. Biol. Chem.275:2349-2358(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;PARTIAL PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      "Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization."
      Seidah N.G. , Mowla S.J. , Hamelin J. , Mamarbachi A.M. , Benjannet S. , Toure B.B. , Basak A. , Munzer J.S. , Marcinkiewicz J. , Zhong M. , Barale J.-C. , Lazure C. , Murphy R.A. , Chretien M. , Marcinkiewicz M.
      Proc. Natl. Acad. Sci. U.S.A.96:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism."
      Marschner K. , Kollmann K. , Schweizer M. , Braulke T. , Pohl S.
      Science333:87-90(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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