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Index > Protein center > Mbtps1(Gene name) > Rat
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  • Mbtps1 (Gene name),
  • Membrane-bound transcription factor site-1 protease (Protein name ),  MBTP1_RAT from NCBI database.
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  • General Annotation
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  • Gene name:
    Mbtps1(S1p;Ski1);
    Protein name:
    Membrane-bound transcription factor site-1 protease;
    Alternative:
    Subtilisin/kexin isozyme 1(SKI-1);Endopeptidase S1P;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein May sort to other organelles, including lysosomal and/or endosomal compartments.
    Protein Attributes:
    Sequence length:
    1052
    Sequence:
    50:
    MKLVNIWLLL | LVVLLCGKKH | LGDRLGKKAF | EKAPCPSCSH | LTLKVEFSST | 
    100:
    VVEYEYIVAF | NGYFTAKARN | SFISSALKSS | EVDNWRIIPR | NNPSSDYPSD | 
    150:
    FEVIQIKEKQ | KAGLLTLEDH | PNIKRVTPQR | KVFRSLKFAE | SDPIVPCNET | 
    200:
    RWSQKWQSSR | PLKRASLSLG | SGFWHATGRH | SSRRLLRAIP | RQVAQTLQAD | 
    250:
    VLWQMGYTGA | NVRVAVFDTG | LSEKHPHFKN | VKERTNWTNE | RTLDDGLGHG | 
    300:
    TFVAGVIASM | RECQGFAPDA | ELHIFRVFTN | NQVSYTSWFL | DAFNYAILKK | 
    350:
    MDVLNLSIGG | PDFMDHPFVD | KVWELTANNV | IMVSAIGNDG | PLYGTLNNPA | 
    400:
    DQMDVIGVGG | IDFEDNIARF | SSRGMTTWEL | PGGYGRVKPD | IVTYGAGVRG | 
    450:
    SGVKGGCRAL | SGTSVASPVV | AGAVTLLVST | VQKRELVNPA | SVKQALIASA | 
    500:
    RRLPGVNMFE | QGHGKLDLLR | AYQILSSYKP | QASLSPSYID | LTECPYMWPY | 
    550:
    CSQPIYYGGM | PTIVNVTILN | GMGVTGRIVD | KPEWRPYLPQ | NGDNIEVAFS | 
    600:
    YSSVLWPWSG | YLAISISVTK | KAASWEGIAQ | GHIMITVASP | AETELKNGAE | 
    650:
    HTSTVKLPIK | VKIIPTPPRS | KRVLWDQYHN | LRYPPGYFPR | DNLRMKNDPL | 
    700:
    DWNGDHVHTN | FRDMYQHLRS | MGYFVEVLGA | PFTCFDATQY | GTLLMVDSEE | 
    750:
    EYFPEEIAKL | RRDVDNGLSL | VVFSDWYNTS | VMRKVKFYDE | NTRQWWMPDT | 
    800:
    GGANVPALNE | LLSVWNMGFS | DGLYEGEFAL | ANHDMYYASG | CSIARFPEDG | 
    850:
    VVITQTFKDQ | GLEVLKQETA | VVDNVPILGL | YQIPAEGGGR | IVLYGDSNCL | 
    900:
    DDSHRQKDCF | WLLDALLQYT | SYGVTPPSLS | HSGNRQRPPS | GAGLAPPERM | 
    950:
    EGNHLHRYSK | VLEAHLGDPK | PRPLPACPHL | SWAKPQPLNE | TAPSNLWKHQ | 
    1000:
    KLLSIDLDKV | VLPNFRSNRP | QVRPLSPGES | GAWDIPGGIM | PGRYNQEVGQ | 
    1050:
    TIPVFAFLGA | MVALAFFVVQ | ISKAKSRPKR | RRPRAKRPQL | AQQAHPARTP | 
    1052:
    SV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Rat Membrane-bound transcription factor site-1 protease
    Protein for Rat Membrane-bound transcription factor site-1 protease
    Protein for Rat Membrane-bound transcription factor site-1 protease
    Protein for Rat Membrane-bound transcription factor site-1 protease

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization."
      Seidah N.G. , Mowla S.J. , Hamelin J. , Mamarbachi A.M. , Benjannet S. , Toure B.B. , Basak A. , Munzer J.S. , Marcinkiewicz J. , Zhong M. , Barale J.-C. , Lazure C. , Murphy R.A. , Chretien M. , Marcinkiewicz M.
      Proc. Natl. Acad. Sci. U.S.A.96:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
      tissue: Adrenal gland.
    2. 2.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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