NOD1 CLIA Kit for Human(Homo sapiens) | EIAab.comNOD1 CLIA Kit for Human(Homo sapiens)

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NOD1 (Gene name),

Nucleotide-binding oligomerization domain-containing protein 1 (Protein name ), NOD1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NOD1(CARD4);

Protein name:

Nucleotide-binding oligomerization domain-containing protein 1;

Alternative:

Caspase recruitment domain-containing protein 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2.

Function:

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.

Subcellular Location:

Cytoplasm Basolateral cell membrane Recruited to the basolateral membrane compartment in polarized epithelial cells.

Protein Attributes:

Sequence length:

953

Sequence:

50:

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850:

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950:

953:

ICF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

605980

String:

Q9Y239

STRING:

9606.ENSP00000222823

SMR:

Q9Y239

Pfam:

PF00619

UniGene:

Hs.405153

KEGG:

hsa:10392

Uniprot:

Q9Y239

FOR

ELISA Kit for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

E14682m

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96T

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ELISA Kit for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

E14682h

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96T

CLIA Kit for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

U14682h

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Packing:

96T

CLIA Kit for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

U14682m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

P14682Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Nucleotide-binding oligomerization domain-containing protein 1

Cat.:

P14682Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Nucleotide-binding oligomerization domain-containing protein 1

Protein for Human Nucleotide-binding oligomerization domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT HIS-447
tissue: Lymph.
2.

"Human Nod1 confers responsiveness to bacterial lipopolysaccharides."
Inohara N. , Ogura Y. , Chen F.F. , Muto A. , Nunez G.
J. Biol. Chem.276:2551-2554(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
3.

"The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction."
Kufer T.A. , Kremmer E. , Adam A.C. , Philpott D.J. , Sansonetti P.J.
Cell. Microbiol.10:477-486(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-208; ASP-711; HIS-788; GLY-792 AND GLN-877
4.

"GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors."
Fukazawa A. , Alonso C. , Kurachi K. , Gupta S. , Lesser C.F. , McCormick B.A. , Reinecker H.C.
PLoS Pathog.4:E1000228-E1000228(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ARHGEF2
5.

"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Lautz K. , Damm A. , Menning M. , Wenger J. , Adam A.C. , Zigrino P. , Kremmer E. , Kufer T.A.
Cell. Microbiol.14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NLRP10;MUTAGENESIS OF LYS-208 AND ASP-287
6.

"The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway."
Zhang R. , Zhao J. , Song Y. , Wang X. , Wang L. , Xu J. , Song C. , Liu F.
Cell. Physiol. Biochem.33:1954-1962(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF34;UBIQUITINATION BY RNF34
7.

"Solution structure of the CARD domain in human caspase recruitment domain protein 4 (NOD1 protein)."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-12) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 14-110
8.

"Crystal structure of the Nod1 caspase activation and recruitment domain."
Coussens N.P. , Mowers J.C. , McDonald C. , Nunez G. , Ramaswamy S.
Biochem. Biophys. Res. Commun.353:1-5(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 16-108;SUBUNIT
9.

"Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK."
Manon F. , Favier A. , Nunez G. , Simorre J.P. , Cusack S.
J. Mol. Biol.365:160-174(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 15-138;FUNCTION;INTERACTION WITH RIPK2;MUTAGENESIS OF VAL-41; LEU-44; ASP-48; GLU-53; ASP-54; GLU-56 AND ARG-69
10.

"Monomer/dimer transition of the caspase-recruitment domain of human Nod1."
Srimathi T. , Robbins S.L. , Dubas R.L. , Hasegawa M. , Inohara N. , Park Y.C.
Biochemistry47:1319-1325(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 9-106;SUBUNIT
11.

"Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB."
Bertin J. , Nir W.-J. , Fischer C.M. , Tayber O.V. , Errada P.R. , Grant J.R. , Keilty J.J. , Gosselin M.L. , Robison K.E. , Wong G.H.W. , Glucksmann M.A. , DiStefano P.S.
J. Biol. Chem.274:12955-12958(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Endothelial cell.
12.

"Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB."
Inohara N. , Koseki T. , del Peso L. , Hu Y. , Yee C. , Chen S. , Carrio R. , Merino J. , Liu D. , Ni J. , Nunez G.
J. Biol. Chem.274:14560-14567(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);MUTAGENESIS OF VAL-41 AND LYS-208
tissue: Mammary gland.
13.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
14.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

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