Per1 CLIA Kit for Mouse(Mus musculus) | EIAab.comPer1 CLIA Kit for Mouse(Mus musculus)

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Per1 (Gene name),

Period circadian protein homolog 1 (Protein name ), PER1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Per1(Per;Rigui);

Protein name:

Period circadian protein homolog 1(mPER1);

Alternative:

Circadian pacemaker protein Rigui;Circadian clock protein PERIOD 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1.

Function:

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences CLOCK function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.

Subcellular Location:

Nucleus Cytoplasm Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.

Protein Attributes:

Sequence length:

1291

Sequence:

50:

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450:

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1000:

1050:

1100:

1150:

1200:

1250:

1291:

EEAQTQIGAK | GSSSQDSAME | EEEQGGGSSS | PALPAEENST | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08447

KEGG:

mmu:18626

UniGene:

Mm.7373

String:

O35973

SMR:

O35973

Pfam:

PF12114

Uniprot:

O35973

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ELISA Kit for Mouse mPER1

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E3144h

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ELISA Kit for Mouse mPER1

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E3144m

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ELISA Kit for Mouse mPER1

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E3144r

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96T

CLIA Kit for Mouse mPER1

Cat.:

U3144r

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96T

CLIA Kit for Mouse mPER1

Cat.:

U3144h

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96T

CLIA Kit for Mouse mPER1

Cat.:

U3144m

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96T

Polyclonal Antibody for Mouse mPER1

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P3144Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse mPER1

Cat.:

P3144Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse mPER1

Cat.:

P3144Rb-h

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Monoclonal Antibody for Mouse mPER1

Protein for Mouse mPER1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Rigui, a putative mammalian ortholog of the Drosophila period gene."
Sun Z.S. , Albrecht U. , Zhuchenko O. , Bailey J. , Eichele G. , Lee C.C.
Cell90:1003-1011(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
tissue: Brain.
2.

"Circadian oscillation of a mammalian homologue of the Drosophila period gene."
Tei H. , Okamura H. , Shigeyoshi Y. , Fukuhara C. , Ozawa R. , Hirose M. , Sakaki Y.
Nature389:512-516(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
strain: BALB/c.
tissue: Brain.
3.

"The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription."
Hida A. , Koike N. , Hirose M. , Hattori M. , Sakaki Y. , Tei H.
Genomics65:224-233(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei."
Shearman L.P. , Zylka M.J. , Weaver D.R. , Kolakowski L.F. Jr. , Reppert S.M.
Neuron19:1261-1269(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
6.

"Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."
Sangoram A.M. , Saez L. , Antoch M.P. , Gekakis N. , Staknis D. , Whiteley A. , Fruechte E.M. , Vitaterna M.H. , Shimomura K. , King D.P. , Young M.W. , Weitz C.J. , Takahashi J.S.
Neuron21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TIMELESS
7.

"Circadian regulation of cryptochrome genes in the mouse."
Miyamoto Y. , Sancar A.
Brain Res. Mol. Brain Res.71:238-243(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
8.

"mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop."
Kume K. , Zylka M.J. , Sriram S. , Shearman L.P. , Weaver D.R. , Jin X. , Maywood E.S. , Hastings M.H. , Reppert S.M.
Cell98:193-205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER3; CRY1 AND CRY2;SUBCELLULAR LOCATION
9.

"A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1."
Takumi T. , Nagamine Y. , Miyake S. , Matsubara C. , Taguchi K. , Takekida S. , Sakakida Y. , Nishikawa K. , Kishimoto T. , Niwa S. , Okumura K. , Okamura H.
Genes Cells4:67-75(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIMELESS;SUBCELLULAR LOCATION
10.

"Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon."
Vielhaber E. , Eide E. , Rivers A. , Gao Z.-H. , Virshup D.M.
Mol. Cell. Biol.20:4888-4899(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER2;PHOSPHORYLATION BY CKSN1E;NUCLEAR LOCALIZATION SIGNAL;SUBCELLULAR LOCATION;MUTAGENESIS OF 831-HIS--ARG-833; 835-LYS--ARG-838 AND 902-THR--THR-914
11.

"Posttranslational mechanisms regulate the mammalian circadian clock."
Lee C. , Etchegaray J.-P. , Cagampang F.R.A. , Loudon A.S.I. , Reppert S.M.
Cell107:855-867(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION;INDUCTION
12.

"Nuclear export of mammalian PERIOD proteins."
Vielhaber E.L. , Duricka D. , Ullman K.S. , Virshup D.M.
J. Biol. Chem.276:45921-45927(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNAL
13.

"Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock."
Bae K. , Jin X. , Maywood E.S. , Hastings M.H. , Reppert S.M. , Weaver D.R.
Neuron30:525-536(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION REPRESSOR OF TRANSLATION;DISRUPTION PHENOTYPE
14.

"The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon."
Eide E.J. , Vielhaber E.L. , Hinz W.A. , Virshup D.M.
J. Biol. Chem.277:17248-17254(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1 AND CRY2;SUBCELLULAR LOCATION
15.

"Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells."
Akashi M. , Tsuchiya Y. , Yoshino T. , Nishida E.
Mol. Cell. Biol.22:1693-1703(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CSNK1D AND CKSN1E;UBIQUITINATION
16.

"A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
Kawamoto T. , Noshiro M. , Sato F. , Maemura K. , Takeda N. , Nagai R. , Iwata T. , Fujimoto K. , Furukawa M. , Miyazaki K. , Honma S. , Honma K.I. , Kato Y.
Biochem. Biophys. Res. Commun.313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Identification of mPer1 phosphorylation sites responsible for the nuclear entry."
Takano A. , Isojima Y. , Nagai K.
J. Biol. Chem.279:32578-32585(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-661 AND SER-663;SUBCELLULAR LOCATION;MUTAGENESIS OF 661-SER--SER-663
18.

"Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock."
Lee C. , Weaver D.R. , Reppert S.M.
Mol. Cell. Biol.24:584-594(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER2; PER3; CRY1 AND CRY2;PHOSPHORYLATION BY CSNK1E
19.

"Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein."
Masubuchi S. , Kataoka N. , Sassone-Corsi P. , Okamura H.
J. Neurosci.25:4719-4724(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PER2 REGULATOR;DISRUPTION PHENOTYPE
20.

"The polycomb group protein EZH2 is required for mammalian circadian clock function."
Etchegaray J.P. , Yang X. , DeBruyne J.P. , Peters A.H. , Weaver D.R. , Jenuwein T. , Reppert S.M.
J. Biol. Chem.281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLOCK AND ARNTL
21.

"Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance."
Chaves I. , Yagita K. , Barnhoorn S. , Okamura H. , van der Horst G.T.J. , Tamanini F.
Mol. Cell. Biol.26:1743-1753(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1 AND CRY2;SUBCELLULAR LOCATION
22.

"Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."
Partch C.L. , Shields K.F. , Thompson C.L. , Selby C.P. , Sancar A.
Proc. Natl. Acad. Sci. U.S.A.103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
23.

"Casein kinase 1 delta regulates the pace of the mammalian circadian clock."
Etchegaray J.P. , Machida K.K. , Noton E. , Constance C.M. , Dallmann R. , Di Napoli M.N. , DeBruyne J.P. , Lambert C.M. , Yu E.A. , Reppert S.M. , Weaver D.R.
Mol. Cell. Biol.29:3853-3866(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION BY CSNK1D AND CSNK1E
24.

"Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock."
Schmutz I. , Wendt S. , Schnell A. , Kramer A. , Mansuy I.M. , Albrecht U.
PLoS ONE6:E21325-E21325(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEPHOSPHORYLATION
25.

"The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1."
Lee H.M. , Chen R. , Kim H. , Etchegaray J.P. , Weaver D.R. , Lee C.
Proc. Natl. Acad. Sci. U.S.A.108:16451-16456(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN CLOCK;PHOSPHORYLATION BY CSNK1D AND CKSN1E;SUBCELLULAR LOCATION
26.

"Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2."
Yang Y. , Duguay D. , Bedard N. , Rachalski A. , Baquiran G. , Na C.H. , Fahrenkrug J. , Storch K.F. , Peng J. , Wing S.S. , Cermakian N.
Biol. Open1:789-801(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP2;UBIQUITINATION;DEUBIQUITINATION
27.

"Distinct roles of DBHS family members in the circadian transcriptional feedback loop."
Kowalska E. , Ripperger J.A. , Muheim C. , Maier B. , Kurihara Y. , Fox A.H. , Kramer A. , Brown S.A.
Mol. Cell. Biol.32:4585-4594(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SFPQ AND NONO
28.

"A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention."
Richards J. , Cheng K.Y. , All S. , Skopis G. , Jeffers L. , Lynch I.J. , Wingo C.S. , Gumz M.L.
Am. J. Physiol.305:F1697-F1704(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION CRY2 REPRESSOR;INTERACTION WITH CRY2; CLOCK AND ARNTL;TISSUE SPECIFICITY
29.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
30.

"Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice."
Noh J.Y. , Han D.H. , Kim M.H. , Ko I.G. , Kim S.E. , Park N. , Kyoung Choe H. , Kim K.H. , Kim K. , Kim C.J. , Cho S.
Exp. Mol. Med.46:E81-E81(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
31.

"A Role for the circadian clock protein Per1 in the regulation of the NaCl Co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells."
Richards J. , Ko B. , All S. , Cheng K.Y. , Hoover R.S. , Gumz M.L.
J. Biol. Chem.289:11791-11806(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS TRANSCRIPTIONAL ACTIVATOR;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
32.

"Modulation of glucocorticoid receptor induction properties by core circadian clock proteins."
Han D.H. , Lee Y.J. , Kim K. , Kim C.J. , Cho S.
Mol. Cell. Endocrinol.383:170-180(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GR REPRESSION
33.

"Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice."
Preussner M. , Wilhelmi I. , Schultz A.S. , Finkernagel F. , Michel M. , Moeroey T. , Heyd F.
Mol. Cell54:651-662(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH U2AF1L4
34.

"Molecular architecture of the mammalian circadian clock."
Partch C.L. , Green C.B. , Takahashi J.S.
Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
35.

"Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function."
Kucera N. , Schmalen I. , Hennig S. , Ollinger R. , Strauss H.M. , Grudziecki A. , Wieczorek C. , Kramer A. , Wolf E.
Proc. Natl. Acad. Sci. U.S.A.109:3311-3316(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 191-502;MUTAGENESIS OF TYR-267; PHE-444 AND TRP-448;FUNCTION IN HEME BINDING;SUBUNIT

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