Gene name:
Piezo1 (Fam38a) ;
Protein name:
Piezo-type mechanosensitive ion channel component 1 ;
Alternative:
Protein FAM38A ;Membrane protein induced by beta-amyloid treatment (Mib) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Endoplasmic reticulum-Golgi intermediate compartment membrane
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MEPHVLGAGL | YWLLLPCTLL | AASLLRFNAL | SLVYLLFLLL | LPWLPGPSRH |
100:
SIPGHTGRLL | RALLCLSLLF | LVAHVAFQIC | LHTMPRLNQL | LGQNCNLWAN |
150:
VSQHIGVTRL | DLKDIFNTTR | LVAPDLGVLV | ASSLCLGLCG | RLTRKARQSQ |
200:
RTQELEEDDI | DAAPAAGLQG | APTLATKRRL | WLAPRFRITA | HWLLVTSGRM |
250:
LVIVLLALAG | IAHPSAFSSV | YLMVFLAICT | WWSCHFPLSS | LGFNTLCVMV |
300:
SCFGAGHLVC | LYCYQTPFVQ | SVLLPGSLWA | RLFGLKNFVD | IPNCSSPNVL |
350:
VLNTKHAWPI | YVSPGILLLL | YYTATSLLKL | RKGRFSELRK | EIPREDEEHE |
400:
LELDQLEPEP | QARGTTQGAT | PTTTGPDIDN | CTVHVLTSQS | PVRQRPVRPR |
450:
LAELKEMSPL | HGLGHLILDQ | SYVCALIAMM | VWSIMYHSWL | TFVLLLWACL |
500:
IWTVRSRHQL | AMLCSPCILL | YGLTLCCLRY | VWAMELPELP | TTLGPVSLHQ |
550:
LGLEHTRYPC | LDLGAMLLYL | LTFWLLLRQF | VKEKLLKKRK | APSTLLEVTV |
600:
SDTEPTQTQT | LLRSLGELVT | GIYVKYWIYV | CAGMFIVVSF | AGRLVVYKIV |
650:
YMFLFLLCLT | LFQVYYTLWR | KLLRVFWWLV | VAYTMLVLIA | VYTFQFQDFP |
700:
TYWRNLTGFT | DEQLGDLGLE | QFSVSELFSS | ILIPGFFLLA | CILQLHYFHR |
750:
PFMQLTDLEH | VPPPGTRRLR | WAHRQDTVSE | APLLQHQEEE | EVFRDDGQSM |
800:
DGPHQTTQVP | EGTASKWGLV | ADRLLDLASS | FSAVLTRIQV | FVRCLLELHV |
850:
FKLVALYTVW | VALKEVSVMN | LLLVVLWAFA | LPYPRFRPMA | SCLSTVWTCI |
900:
IIVCKMLYQL | KIVNPHEYSS | NCTEPFPNNT | NLQPLEISQS | LLYRGPVDPA |
950:
NWFGVRKGYP | NLGYIQNHLQ | ILLLLVFEAV | VYRRQEHYRR | QHQQAPLPAQ |
1000:
ALCADGTRQR | LDQDLLSCLK | YFINFFFYKF | GLEICFLMAV | NVIGQRMNFM |
1050:
VILHGCWLVA | ILTRRRREAI | ARLWPNYCLF | LTLFLLYQYL | LCLGMPPALC |
1100:
IDYPWRWSQA | IPMNSALIKW | LYLPDFFRAP | NSTNLISDFL | LLLCASQQWQ |
1150:
VFSAEQTEEW | QRMAGVNTDH | LEPLRGEPNP | IPNFIHCRSY | LDMLKVAVFR |
1200:
YLFWLVLVVV | FVTGATRISI | FGLGYLLACF | YLLLFGTTLL | QKDTRAQLVL |
1250:
WDCLILYNVT | VIISKNMLSL | LSCVFVEQMQ | SNFCWVIQLF | SLVCTVKGYY |
1300:
DPKEMKTRDR | DCLLPVEEAG | IIWDSICFFF | LLLQRRVFLS | HYFLHVSADL |
1350:
KATALQASRG | FALYNAANIK | NINFHRQTEE | RSLAQLKRQM | KRIRAKQEKY |
1400:
RQSQASRGQL | QSTDPQEPGP | DSPGGSSPPR | TQWWRPWQDH | ATVIHSGDYF |
1450:
LFESDSEEEE | EALPEDPRPA | AQSAFQMAYQ | AWVTNAQTVL | RQRREQARRD |
1500:
RAEQLASGGD | LSPEVELVDV | PENEMAGHSH | VMQRVLSTMQ | FLWVLGQATV |
1550:
DGLTRWLRTF | TKDHRTMSDV | LCAERYLLTQ | ELLRGGEVHR | GVLDQLYVSE |
1600:
DEIALSGPVE | NRDGPSTASS | GLGAEEPLSS | MTDDTGSPLS | TGYNTRSGSE |
1650:
EIITDTGGLQ | AGTSLHGSQE | LLANARTRMR | TASELLLDRR | LRIPELEEAE |
1700:
QFEAQQGRTL | RLLRAMYQCV | AAHSELLCYF | IIILNHMVTA | SAASLVLPVL |
1750:
VFLWAMLTIP | RPSKRFWMTA | IVFTEVMVVT | KYLFQFGFFP | WNSYIVLRRY |
1800:
ENKPYFPPRI | LGLEKTDSYI | KYDLVQLMAL | FFHRSQLLCY | GLWDHEEDGV |
1850:
PKDHCRSSEK | DQEAEEESEA | KLESQPETGT | GHPEEPVLTG | TPKDHIQGKG |
1900:
SVRSKDEIQD | PPEDLKPQHR | RHISIRFRRR | KETQGPKGAA | VVEAEHEEGE |
1950:
EGREAAGRKR | LRRPREGLKI | REKMKAAGRR | LQSFCLSLAQ | SFYQPLRRFF |
2000:
HDILHTKYRA | ATDVYALMFL | ADIVDIVVII | FGFWAFGKHS | AATDIASSLS |
2050:
DDQVPQAFLF | MLLVQFGTMV | IDRALYLRKT | VLGNLAFQVV | LVVAIHLWMF |
2100:
FILPAVTERM | FRQNAVAQLW | YFVKCIYFAL | SAYQIRCGYP | TRILGNFLTK |
2150:
KYNHLNLFLF | QGFRLVPFLV | ELRAVMDWVW | TDTTLSLSNW | MCVEDIYANI |
2200:
FIIKCSRETE | KKYPQPKGQK | KKKIVKYGMG | GLIILFLIAI | IWFPLLFMSL |
2250:
IRSVVGVVNQ | PIDVTVTLKL | GGYEPLFTMS | AQQPSIVPFT | PEDYEELSQQ |
2300:
FDPYPLAMQF | ISQYSPEDIV | TAQIEGSSGA | LWRISPPSRA | QMKHELYNGT |
2350:
ADITLRFTWN | FQRDLAKGGS | VEYTNEKHTL | ELAPNSTARR | QLAQLLEGRP |
2400:
DQSVVIPHLF | PKYIRAPNGP | EANPVKQLQP | DEEEDYLGVR | IQLRREQVGT |
2450:
GTSGEQAGTK | ASDFLEWWVI | ELQDCQAECN | LLPMVIFSDK | VSPPSLGFLA |
2500:
GYGIVGLYVS | IVLVVGKFVR | GFFSDISHSI | MFEELPCVDR | ILKLCQDIFL |
2535:
VRETRELELE | EELYAKLIFL | YRSPETMIKW | TREKE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Piezo-type mechanosensitive ion channel component 1
ELISA Kit for Rat Piezo-type mechanosensitive ion channel component 1
ELISA Kit for Rat Piezo-type mechanosensitive ion channel component 1
CLIA Kit for Rat Piezo-type mechanosensitive ion channel component 1
CLIA Kit for Rat Piezo-type mechanosensitive ion channel component 1
CLIA Kit for Rat Piezo-type mechanosensitive ion channel component 1
Polyclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Polyclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Polyclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Monoclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Monoclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Monoclonal Antibody for Rat Piezo-type mechanosensitive ion channel component 1
Protein for Rat Piezo-type mechanosensitive ion channel component 1
Protein for Rat Piezo-type mechanosensitive ion channel component 1
Protein for Rat Piezo-type mechanosensitive ion channel component 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
"A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes."
Satoh K.
,
Hata M.
,
Takahara S.
,
Tsuzaki H.
,
Yokota H.
,
Akatsu H.
,
Yamamoto T.
,
Kosaka K.
,
Yamada T.
Brain Res.1108:19-27(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 430-2535;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
strain :
Wistar .
tissue :
Astrocyte .