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Index > Protein center > PIM2(Gene name) > Human
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  • PIM2 (Gene name),
  • Serine/threonine-protein kinase pim-2 (Protein name ),  PIM2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PIM2;
    Protein name:
    Serine/threonine-protein kinase pim-2;
    Alternative:
    Pim-2h;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MYC.
    Function:
    Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerced by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    311
    Sequence:
    50:
    MLTKPLQGPP | APPGTPTPPP | GGKDREAFEA | EYRLGPLLGK | GGFGTVFAGH | 
    100:
    RLTDRLQVAI | KVIPRNRVLG | WSPLSDSVTC | PLEVALLWKV | GAGGGHPGVI | 
    150:
    RLLDWFETQE | GFMLVLERPL | PAQDLFDYIT | EKGPLGEGPS | RCFFGQVVAA | 
    200:
    IQHCHSRGVV | HRDIKDENIL | IDLRRGCAKL | IDFGSGALLH | DEPYTDFDGT | 
    250:
    RVYSPPEWIS | RHQYHALPAT | VWSLGILLYD | MVCGDIPFER | DQEILEAELH | 
    300:
    FPAHVSPDCC | ALIRRCLAPK | PSSRPSLEEI | LLDPWMQTPA | EDVPLNPSKG | 
    311:
    GPAPLAWSLL | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase pim-2
    Cat.:
    E5627m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Serine/threonine-protein kinase pim-2
    Cat.:
    E5627h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein kinase pim-2
    Cat.:
    U5627h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein kinase pim-2
    Cat.:
    U5627m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Serine/threonine-protein kinase pim-2
    Cat.:
    P5627Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serine/threonine-protein kinase pim-2
    Cat.:
    P5627Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Serine/threonine-protein kinase pim-2
    Monoclonal Antibody for Human Serine/threonine-protein kinase pim-2
    Protein for Human Serine/threonine-protein kinase pim-2
    Protein for Human Serine/threonine-protein kinase pim-2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The human Pim-2 proto-oncogene and its testicular expression."
      Baytel D. , Shalom S. , Madgar I. , Weissenberg R. , Don J.
      Biochim. Biophys. Acta1442:274-285(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Genomic organization of the human UDP-galactose transporter gene."
      Ishida N. , Miura N. , Yamauchi M. , Kawakita M.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    6. 6.
      "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F. , Chow V.T.
      Cell. Microbiol.8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
    7. 7.
      "Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels."
      Morishita D. , Katayama R. , Sekimizu K. , Tsuruo T. , Fujita N.
      Cancer Res.68:5076-5085(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDKN1B
    8. 8.
      "Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell."
      Gong J. , Wang J. , Ren K. , Liu C. , Li B. , Shi Y.
      J. Surg. Res.153:17-22(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    9. 9.
      "Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells."
      Wang Z. , Zhang Y. , Gu J.J. , Davitt C. , Reeves R. , Magnuson N.S.
      Int. J. Biochem. Cell Biol.42:1030-1038(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDKN1A
    10. 10.
      "Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor."
      Bullock A.N. , Russo S. , Amos A. , Pagano N. , Bregman H. , Debreczeni J.E. , Lee W.H. , von Delft F. , Meggers E. , Knapp S.
      PLoS ONE4:E7112-E7112(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH RUTHENIUM-PYRIDOCARBAZOLE-1
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