Protein name:
Serine/threonine-protein kinase pim-2 ;
Alternative:
Pim-2h ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MYC.
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerced by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Subcellular Location:
N/A
Protein Attributes:
50:
MLTKPLQGPP | APPGTPTPPP | GGKDREAFEA | EYRLGPLLGK | GGFGTVFAGH |
100:
RLTDRLQVAI | KVIPRNRVLG | WSPLSDSVTC | PLEVALLWKV | GAGGGHPGVI |
150:
RLLDWFETQE | GFMLVLERPL | PAQDLFDYIT | EKGPLGEGPS | RCFFGQVVAA |
200:
IQHCHSRGVV | HRDIKDENIL | IDLRRGCAKL | IDFGSGALLH | DEPYTDFDGT |
250:
RVYSPPEWIS | RHQYHALPAT | VWSLGILLYD | MVCGDIPFER | DQEILEAELH |
300:
FPAHVSPDCC | ALIRRCLAPK | PSSRPSLEEI | LLDPWMQTPA | EDVPLNPSKG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Serine/threonine-protein kinase pim-2
ELISA Kit for Human Serine/threonine-protein kinase pim-2
CLIA Kit for Human Serine/threonine-protein kinase pim-2
CLIA Kit for Human Serine/threonine-protein kinase pim-2
Polyclonal Antibody for Human Serine/threonine-protein kinase pim-2
Polyclonal Antibody for Human Serine/threonine-protein kinase pim-2
Monoclonal Antibody for Human Serine/threonine-protein kinase pim-2
Monoclonal Antibody for Human Serine/threonine-protein kinase pim-2
Protein for Human Serine/threonine-protein kinase pim-2
Protein for Human Serine/threonine-protein kinase pim-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] ASP-138 AND VAL-280