Pnpla2 CLIA Kit for Mouse(Mus musculus) | EIAab.comPnpla2 CLIA Kit for Mouse(Mus musculus)

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Pnpla2 (Gene name),

Patatin-like phospholipase domain-containing protein 2 (Protein name ), PLPL2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pnpla2(Atgl);

Protein name:

Patatin-like phospholipase domain-containing protein 2;

Alternative:

Desnutrin;Adipose triglyceride lipase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity. Interacts with SERPINF1; interacts at one site of interaction (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN.

Function:

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

Subcellular Location:

Lipid droplet Cell membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

486

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

486:

CTNVAFPPDA | LRMRAPASPT | AADPATPQDP | PGLPPC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8BJ56

Pfam:

PF01734

KEGG:

mmu:66853

UniGene:

Mm.29998

Uniprot:

Q8BJ56

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ELISA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

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E8796h

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96T

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ELISA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

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E8796r

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96T

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ELISA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

E8796m

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ELISA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

E8796b

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96T

CLIA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796m

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Packing:

96T

CLIA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796h

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96T

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Polyclonal Antibody for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

P8796Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Patatin-like phospholipase domain-containing protein 2

Cat.:

P8796Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse Patatin-like phospholipase domain-containing protein 2

Protein for Mouse Patatin-like phospholipase domain-containing protein 2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis."
Villena J.A. , Roy S. , Sarkadi-Nagy E. , Kim K.-H. , Sul H.S.
J. Biol. Chem.279:47066-47075(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
strain: C57BL/6.
tissue: White adipose tissue.
2.

"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase."
Zimmermann R. , Strauss J.G. , Haemmerle G. , Schoiswohl G. , Birner-Gruenberger R. , Riederer M. , Lass A. , Neuberger G. , Eisenhaber F. , Hermetter A. , Zechner R.
Science306:1383-1386(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION
strain: C57BL/6.
3.

"The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma."
Kim J.Y. , Tillison K. , Lee J.-H. , Rearick D.A. , Smas C.M.
Am. J. Physiol.291:E115-E127(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
strain: C57BL/6.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Kidney.
tissue: Testis.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
strain: FVB/N.
tissue: Trophoblast stem cell.
6.

"Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
Chu C.C. , Paul W.E.
Mol. Immunol.35:487-502(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-473
strain: BALB/c.
tissue: Spleen.
7.

"Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members."
Lake A.C. , Sun Y. , Li J.-L. , Kim J.E. , Johnson J.W. , Li D. , Revett T. , Shih H.H. , Liu W. , Paulsen J.E. , Gimeno R.E.
J. Lipid Res.46:2477-2487(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
8.

"Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes."
Kralisch S. , Klein J. , Lossner U. , Bluher M. , Paschke R. , Stumvoll M. , Fasshauer M.
Mol. Cell. Endocrinol.240:43-49(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
9.

"Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome."
Lass A. , Zimmermann R. , Haemmerle G. , Riederer M. , Schoiswohl G. , Schweiger M. , Kienesberger P. , Strauss J.G. , Gorkiewicz G. , Zechner R.
Cell Metab.3:309-319(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH ABHD5;MUTAGENESIS OF SER-47
10.

"Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin."
Kershaw E.E. , Hamm J.K. , Verhagen L.A.W. , Peroni O. , Katic M. , Flier J.S.
Diabetes55:148-157(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
11.

"Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism."
Schweiger M. , Schreiber R. , Haemmerle G. , Lass A. , Fledelius C. , Jacobsen P. , Tornqvist H. , Zechner R. , Zimmermann R.
J. Biol. Chem.281:40236-40241(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
12.

"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase."
Haemmerle G. , Lass A. , Zimmermann R. , Gorkiewicz G. , Meyer C. , Rozman J. , Heldmaier G. , Maier R. , Theussl C. , Eder S. , Kratky D. , Wagner E.F. , Klingenspor M. , Hoefler G. , Zechner R.
Science312:734-737(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
13.

"Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes."
Miyoshi H. , Perfield J.W. II , Souza S.C. , Shen W.-J. , Zhang H.-H. , Stancheva Z.S. , Kraemer F.B. , Obin M.S. , Greenberg A.S.
J. Biol. Chem.282:996-1002(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
14.

"Analysis of lipolytic protein trafficking and interactions in adipocytes."
Granneman J.G. , Moore H.-P.H. , Granneman R.L. , Greenberg A.S. , Obin M.S. , Zhu Z.
J. Biol. Chem.282:5726-5735(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ABHD5;LACK OF INTERACTION WITH PLIN
15.

"Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase."
Granneman J.G. , Moore H.P. , Mottillo E.P. , Zhu Z. , Zhou L.
J. Biol. Chem.286:5126-5135(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLIN5;EXCLUSION OF INTERACTION WITH ABHD5
16.

"Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein."
Wang H. , Bell M. , Sreenivasan U. , Sreenevasan U. , Hu H. , Liu J. , Dalen K. , Londos C. , Yamaguchi T. , Rizzo M.A. , Coleman R. , Gong D. , Brasaemle D. , Sztalryd C.
J. Biol. Chem.286:15707-15715(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLIN5
17.

"Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase."
Pagnon J. , Matzaris M. , Stark R. , Meex R.C. , Macaulay S.L. , Brown W. , O'Brien P.E. , Tiganis T. , Watt M.J.
Endocrinology153:4278-4289(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-374; SER-396; SER-406; SER-430 AND SER-468;MUTAGENESIS OF SER-396 AND SER-406

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