PRNP CLIA Kit for Dog(Canis familiaris) | EIAab.comPRNP CLIA Kit for Dog(Canis familiaris)

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Index > Protein center > PRNP(Gene name) > Dog

PRNP (Gene name),

Major prion protein (Protein name ), PRIO_CANFA from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PRNP(PRP);

Protein name:

Major prion protein(PrP);

Alternative:

CD:

CD230;

Organism:

Dog (Canis familiarisCanis lupus familiaris).

General Annotation

Sub Unit:

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with APP, GRB2, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement.

Function:

The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor Golgi apparatus

Protein Attributes:

Sequence length:

255

Sequence:

50:

100:

150:

200:

250:

255:

FLIVG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O46501

Pfam:

PF00377

Uniprot:

O46501

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ELISA Kit for Dog PrP

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E9345h

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96T

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ELISA Kit for Dog PrP

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E9345m

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96T

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ELISA Kit for Dog PrP

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E9345c

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ELISA Kit for Dog PrP

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ELISA Kit for Dog PrP

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E9345r

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ELISA Kit for Dog PrP

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E9345b

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ELISA Kit for Dog PrP

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ELISA Kit for Dog PrP

Cat.:

E9345p

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96T

CLIA Kit for Dog PrP

Cat.:

U9345h

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96T

CLIA Kit for Dog PrP

Cat.:

U9345r

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96T

CLIA Kit for Dog PrP

Cat.:

U9345m

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96T

CLIA Kit for Dog PrP

Cat.:

U9345b

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96T

CLIA Kit for Dog PrP

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CLIA Kit for Dog PrP

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CLIA Kit for Dog PrP

MSDS:

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CLIA Kit for Dog PrP

Cat.:

U9345p

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Packing:

96T

Polyclonal Antibody for Dog PrP

Cat.:

P9345Rb-h

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40ug/0.2ml

Polyclonal Antibody for Dog PrP

Cat.:

P9345Rb-m

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40ug/0.2ml

Monoclonal Antibody for Dog PrP

Protein for Dog PrP

R&D Technical Data

12% SDS-PAGE Analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤5.6%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤10.6%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-106
Plasma	98	92-108

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-102%	92-103%	95-105%	92-107%
EDTA plasma(n=5)	88-96%	93-101%	94-102%	95-106%
heparin plasma(n=5)	93-104%	94-105%	101-106%	95-109%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

Rohwer R.G. , Edelman D.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Prion protein NMR structures of cats, dogs, pigs, and sheep."
Lysek D.A. , Schorn C. , Nivon L.G. , Esteve-Moya V. , Christen B. , Calzolai L. , von Schroetter C. , Fiorito F. , Herrmann T. , Guentert P. , Wuethrich K.
Proc. Natl. Acad. Sci. U.S.A.102:640-645(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 124-233

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