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Index > Protein center > REC8(Gene name) > Human
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  • REC8 (Gene name),
  • Meiotic recombination protein REC8 homolog (Protein name ),  REC8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    REC8(REC8L1);
    Protein name:
    Meiotic recombination protein REC8 homolog;
    Alternative:
    Cohesin Rec8p;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51.
    Function:
    Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
    Subcellular Location:
    Nucleus Chromosome In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.
    Protein Attributes:
    Sequence length:
    547
    Sequence:
    50:
    MFYYPNVLQR | HTGCFATIWL | AATRGSRLVK | REYLRVNVVK | TCEEILNYVL | 
    100:
    VRVQPPQPGL | PRPRFSLYLS | AQLQIGVIRV | YSQQCQYLVE | DIQHILERLH | 
    150:
    RAQLQIRIDM | ETELPSLLLP | NHLAMMETLE | DAPDPFFGMM | SVDPRLPSPF | 
    200:
    DIPQIRHLLE | AAIPERVEEI | PPEVPTEPRE | PERIPVTVLP | PEAITILEAE | 
    250:
    PIRMLEIEGE | RELPEVSRRE | LDLLIAEEEE | AILLEIPRLP | PPAPAEVEGI | 
    300:
    GEALGPEELR | LTGWEPGALL | MEVTPPEELR | LPAPPSPERR | PPVPPPPRRR | 
    350:
    RRRRLLFWDK | ETQISPEKFQ | EQLQTRAHCW | ECPMVQPPER | TIRGPAELFR | 
    400:
    TPTLSGWLPP | ELLGLWTHCA | QPPPKALRRE | LPEEAAAEEE | RRKIEVPSEI | 
    450:
    EVPREALEPS | VPLMVSLEIS | LEAAEEEKSR | ISLIPPEERW | AWPEVEAPEA | 
    500:
    PALPVVPELP | EVPMEMPLVL | PPELELLSLE | AVHRAVALEL | QANREPDFSS | 
    547:
    LVSPLSPRRM | AARVFYLLLV | LSAQQILHVK | QEKPYGRLLI | QPGPRFH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    E4955h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    E4955m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    E4955r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    U4955r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    U4955h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Meiotic recombination protein REC8 homolog
    Cat.:
    U4955m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Cat.:
    P4955Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Cat.:
    P4955Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Cat.:
    P4955Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
    Protein for Human Meiotic recombination protein REC8 homolog
    Protein for Human Meiotic recombination protein REC8 homolog
    Protein for Human Meiotic recombination protein REC8 homolog

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans."
      Parisi S. , McKay M.J. , Molnar M. , Thompson M.A. , van der Spek P.J. , van Drunen-Schoenmaker E. , Kanaar R. , Lehmann E. , Hoeijmakers J.H.J. , Kohli J.
      Mol. Cell. Biol.19:3515-3528(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Teratocarcinoma.
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Stomach.
    5. 5.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-411
      tissue: Lung.
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