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Index > Protein center > SLC12A5(Gene name) > Human
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  • SLC12A5 (Gene name),
  • Solute carrier family 12 member 5 (Protein name ),  S12A5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    SLC12A5(KCC2;KIAA1176);
    Protein name:
    Solute carrier family 12 member 5;
    Alternative:
    K-Cl cotransporter 2(hKCC2);Electroneutral potassium-chloride cotransporter 2;Neuronal K-Cl cotransporter;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1.
    Function:
    Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1139
    Sequence:
    50:
    MSRRFTVTSL | PPAGPARSPD | PESRRHSVAD | PRHLPGEDVK | GDGNPKESSP | 
    100:
    FINSTDTEKG | KEYDGKNMAL | FEEEMDTSPM | VSSLLSGLAN | YTNLPQGSRE | 
    150:
    HEEAENNEGG | KKKPVQAPRM | GTFMGVYLPC | LQNIFGVILF | LRLTWVVGIA | 
    200:
    GIMESFCMVF | ICCSCTMLTA | ISMSAIATNG | VVPAGGSYYM | ISRSLGPEFG | 
    250:
    GAVGLCFYLG | TTFAGAMYIL | GTIEILLAYL | FPAMAIFKAE | DASGEAAAML | 
    300:
    NNMRVYGTCV | LTCMATVVFV | GVKYVNKFAL | VFLGCVILSI | LAIYAGVIKS | 
    350:
    AFDPPNFPIC | LLGNRTLSRH | GFDVCAKLAW | EGNETVTTRL | WGLFCSSRFL | 
    400:
    NATCDEYFTR | NNVTEIQGIP | GAASGLIKEN | LWSSYLTKGV | IVERSGMTSV | 
    450:
    GLADGTPIDM | DHPYVFSDMT | SYFTLLVGIY | FPSVTGIMAG | SNRSGDLRDA | 
    500:
    QKSIPTGTIL | AIATTSAVYI | SSVVLFGACI | EGVVLRDKFG | EAVNGNLVVG | 
    550:
    TLAWPSPWVI | VIGSFFSTCG | AGLQSLTGAP | RLLQAISRDG | IVPFLQVFGH | 
    600:
    GKANGEPTWA | LLLTACICEI | GILIASLDEV | APILSMFFLM | CYMFVNLACA | 
    650:
    VQTLLRTPNW | RPRFRYYHWT | LSFLGMSLCL | ALMFICSWYY | ALVAMLIAGL | 
    700:
    IYKYIEYRGA | EKEWGDGIRG | LSLSAARYAL | LRLEEGPPHT | KNWRPQLLVL | 
    750:
    VRVDQDQNVV | HPQLLSLTSQ | LKAGKGLTIV | GSVLEGTFLE | NHPQAQRAEE | 
    800:
    SIRRLMEAEK | VKGFCQVVIS | SNLRDGVSHL | IQSGGLGGLQ | HNTVLVGWPR | 
    850:
    NWRQKEDHQT | WRNFIELVRE | TTAGHLALLV | TKNVSMFPGN | PERFSEGSID | 
    900:
    VWWIVHDGGM | LMLLPFLLRH | HKVWRKCKMR | IFTVAQMDDN | SIQMKKDLTT | 
    950:
    FLYHLRITAE | VEVVEMHESD | ISAYTYEKTL | VMEQRSQILK | QMHLTKNERE | 
    1000:
    REIQSITDES | RGSIRRKNPA | NTRLRLNVPE | ETAGDSEEKP | EEEVQLIHDQ | 
    1050:
    SAPSCPSSSP | SPGEEPEGEG | ETDPEKVHLT | WTKDKSVAEK | NKGPSPVSSE | 
    1100:
    GIKDFFSMKP | EWENLNQSNV | RRMHTAVRLN | EVIVKKSRDA | KLVLLNMPGP | 
    1139:
    PRNRNGDENY | MEFLEVLTEH | LDRVMLVRGG | GREVITIYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Solute carrier family 12 member 5
    Cat.:
    E9328m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Solute carrier family 12 member 5
    Cat.:
    E9328h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Solute carrier family 12 member 5
    Cat.:
    E9328r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 5
    Cat.:
    U9328m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 5
    Cat.:
    U9328h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Solute carrier family 12 member 5
    Cat.:
    U9328r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Solute carrier family 12 member 5
    Cat.:
    P9328Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 12 member 5
    Cat.:
    P9328Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 12 member 5
    Cat.:
    P9328Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Solute carrier family 12 member 5
    Monoclonal Antibody for Human Solute carrier family 12 member 5
    Monoclonal Antibody for Human Solute carrier family 12 member 5
    Protein for Human Solute carrier family 12 member 5
    Protein for Human Solute carrier family 12 member 5
    Protein for Human Solute carrier family 12 member 5

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter."
      Song L. , Mercado A. , Vazquez N. , Xie Q. , Desai R. , George A.L. Jr. , Gamba G. , Mount D.B.
      Brain Res. Mol. Brain Res.103:91-105(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
      Kimura K. , Wakamatsu A. , Suzuki Y. , Ota T. , Nishikawa T. , Yamashita R. , Yamamoto J. , Sekine M. , Tsuritani K. , Wakaguri H. , Ishii S. , Sugiyama T. , Saito K. , Isono Y. , Irie R. , Kushida N. , Yoneyama T. , Otsuka R. , more...
      Genome Res.16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1)
    5. 5.
      "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M. , Nagase T. , Ishikawa K. , Kikuno R. , Nomura N. , Ohara O.
      DNA Res.6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-1109 (ISOFORM 2);VARIANT LEU-1100
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-847
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