SIGMAR1 CLIA Kit for Human(Homo sapiens) | EIAab.comSIGMAR1 CLIA Kit for Human(Homo sapiens)

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SIGMAR1 (Gene name),

Sigma non-opioid intracellular receptor 1 (Protein name ), SGMR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SIGMAR1(AAG8;OPRS1;SRBP);

Protein name:

Sigma non-opioid intracellular receptor 1;

Alternative:

SR31747-binding protein(SR-BP);Aging-associated gene 8 protein;Sigma 1-type opioid receptor(SIG-1R;Sigma1-receptor;Sigma1R;hSigmaR1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4.

Function:

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

Subcellular Location:

Nucleus inner membrane Nucleus outer membrane Endoplasmic reticulum membrane Lipid droplet Cell junction Cell membrane Cell projection growth cone Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

Protein Attributes:

Sequence length:

223

Sequence:

50:

100:

150:

200:

223:

YTLRSYARGL | RLELTTYLFG | QDP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.522087

String:

Q99720

MIM:

601978

Pfam:

PF04622

KEGG:

hsa:10280

Uniprot:

Q99720

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ELISA Kit for Human Sigma non-opioid intracellular receptor 1

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E5642h

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96T

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ELISA Kit for Human Sigma non-opioid intracellular receptor 1

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E5642r

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96T

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ELISA Kit for Human Sigma non-opioid intracellular receptor 1

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E5642b

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96T

ELISA Kit for Human Sigma non-opioid intracellular receptor 1

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E5642c

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96T

ELISA Kit for Human Sigma non-opioid intracellular receptor 1

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E5642m

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96T

CLIA Kit for Human Sigma non-opioid intracellular receptor 1

Cat.:

U5642r

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96T

CLIA Kit for Human Sigma non-opioid intracellular receptor 1

Cat.:

U5642h

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MSDS:

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Packing:

96T

CLIA Kit for Human Sigma non-opioid intracellular receptor 1

Cat.:

U5642m

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Packing:

96T

CLIA Kit for Human Sigma non-opioid intracellular receptor 1

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U5642c

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96T

CLIA Kit for Human Sigma non-opioid intracellular receptor 1

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U5642b

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96T

Polyclonal Antibody for Human Sigma non-opioid intracellular receptor 1

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P5642Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Sigma non-opioid intracellular receptor 1

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P5642Rb-m

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Polyclonal Antibody for Human Sigma non-opioid intracellular receptor 1

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P5642Rb-r

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Monoclonal Antibody for Human Sigma non-opioid intracellular receptor 1

Protein for Human Sigma non-opioid intracellular receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)."
Kekuda R. , Prasad P.D. , Fei Y.-J. , Leibach F.H. , Ganapathy V.
Biochem. Biophys. Res. Commun.229:553-558(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Choriocarcinoma.
2.

"Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase."
Jbilo O. , Vidal H. , Paul R. , De Nys N. , Bensaid M. , Silve S. , Carayon P. , Davi D. , Galiegue S. , Bourrie B. , Guillemot J.-C. , Ferrara P. , Loison G. , Maffrand J.-P. , Le Fur G. , Casellas P.
J. Biol. Chem.272:27107-27115(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 40-47; 48-60; 61-64; 120-133 AND 212-222;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue: Lymphoblast.
3.

"Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene."
Prasad P.D. , Li H.W. , Fei Y.-J. , Ganapathy M.E. , Fujita T. , Plumley L.H. , Yang-Feng T.L. , Leibach F.H. , Ganapathy V.
J. Neurochem.70:443-451(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Wang L.-M. , Shelness G.S. , Childers S.R. , Mach R.H. , Wheeler K.T.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Mammary gland.
5.

"Identification of a human aging-associated gene."
Kim J.W.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"A new splice variant of sigma-1 identified in human breast cancer biopsy sample."
Zhang J. , Aft R.L. , Zhang F. , Mach R.H.
Submitted (2006-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4)
tissue: Mammary cancer.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue: Thyroid.
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Kidney.
10.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue: Brain.
tissue: Muscle.
13.

"Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level."
Dussossoy D. , Carayon P. , Belugou S. , Feraut D. , Bord A. , Goubet C. , Roque C. , Vidal H. , Combes T. , Loison G. , Casellas P.
Eur. J. Biochem.263:377-386(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
14.

"Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line."
Ganapathy M.E. , Prasad P.D. , Huang W. , Seth P. , Leibach F.H. , Ganapathy V.
J. Pharmacol. Exp. Ther.289:251-260(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM 3)
15.

"Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor."
Seth P. , Ganapathy M.E. , Conway S.J. , Bridges C.D. , Smith S.B. , Casellas P. , Ganapathy V.
Biochim. Biophys. Acta1540:59-67(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-123; ASP-126; GLU-138; GLU-144; GLU-150; GLU-158; GLU-163; GLU-172; ASP-188; ASP-195 AND GLU-213
16.

"Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina."
Ola M.S. , Moore P. , El-Sherbeny A. , Roon P. , Agarwal N. , Sarthy V.P. , Casellas P. , Ganapathy V. , Smith S.B.
Brain Res. Mol. Brain Res.95:86-95(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
17.

"Silencing of sigma-1 receptor induces cell death in human lens cells."
Wang L. , Duncan G.
Exp. Cell Res.312:1439-1446(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Lack of association between sigma receptor gene variants and schizophrenia."
Satoh F. , Miyatake R. , Furukawa A. , Suwaki H.
Psychiatry Clin. Neurosci.58:359-363(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-2 AND GLN-211
20.

"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis."
Al-Saif A. , Al-Mohanna F. , Bohlega S.
Ann. Neurol.70:913-919(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALS16 GLN-102;CHARACTERIZATION OF VARIANT ALS16 GLN-102

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