Shank1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comShank1 CLIA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Shank1(Gene name) > Rat

Shank1 (Gene name),

SH3 and multiple ankyrin repeat domains protein 1 (Protein name ), SHAN1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Shank1;

Protein name:

SH3 and multiple ankyrin repeat domains protein 1(Shank1);

Alternative:

SPANK-1;GKAP/SAPAP-interacting protein;Synamon;Somatostatin receptor-interacting protein(SSTR-interacting protein;SSTRIP);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9.

Function:

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.

Subcellular Location:

Cytoplasm Cell junction synapse Cell junction synapse postsynaptic cell membrane postsynaptic density Postsynaptic density of neuronal cells. Colocalizes with alpha-latrotoxin receptor 1.

Protein Attributes:

Sequence length:

2167

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2167:

VGHRMNIDRA | LKFFLER

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.225968

Pfam:

PF12796

SMR:

Q9WV48

String:

Q9WV48

KEGG:

rno:78957

Uniprot:

Q9WV48

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ELISA Kit for Rat Shank1

Cat.:

E14502r

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96T

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ELISA Kit for Rat Shank1

Cat.:

E14502m

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96T

ELISA Kit for Rat Shank1

Cat.:

E14502h

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96T

CLIA Kit for Rat Shank1

Cat.:

U14502m

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96T

CLIA Kit for Rat Shank1

Cat.:

U14502h

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96T

CLIA Kit for Rat Shank1

Cat.:

U14502r

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96T

Polyclonal Antibody for Rat Shank1

Cat.:

P14502Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Shank1

Cat.:

P14502Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Shank1

Cat.:

P14502Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Shank1

Protein for Rat Shank1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein."
Yao I. , Hata Y. , Hirao K. , Deguchi M. , Ide N. , Takeuchi M. , Takai Y.
J. Biol. Chem.274:27463-27466(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);INTERACTION WITH DLGAP1 AND DLG4
tissue: Brain.
2.

"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
Naisbitt S. , Kim E. , Tu J.C. , Xiao B. , Sala C. , Valtschanoff J. , Weinberg R.J. , Worley P.F. , Sheng M.
Neuron23:569-582(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);INTERACTION WITH DLGAP1
strain: Sprague-Dawley.
3.

"The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
Tobaben S. , Suedhof T.C. , Stahl B.
J. Biol. Chem.275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

"Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
Lim S. , Naisbitt S. , Yoon J. , Hwang J.-I. , Suh P.-G. , Sheng M. , Kim E.
J. Biol. Chem.274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4 AND 5);DEVELOPMENTAL STAGE
tissue: Brain.
5.

"Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
Zitzer H. , Hoenck H.-H. , Baechner D. , Richter D. , Kreienkamp H.-J.
J. Biol. Chem.274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 4)
tissue: Brain.
6.

"Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
Tu J.C. , Xiao B. , Naisbitt S. , Yuan J.P. , Petralia R.S. , Brakeman P. , Doan A. , Aakalu V.K. , Lanahan A.A. , Sheng M. , Worley P.F.
Neuron23:583-592(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HOMER1;SUBCELLULAR LOCATION
7.

"Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin."
Bockers T.M. , Mameza M.G. , Kreutz M.R. , Bockmann J. , Weise C. , Buck F. , Richter D. , Gundelfinger E.D. , Kreienkamp H.-J.
J. Biol. Chem.276:40104-40112(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPTAN1
8.

"Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins."
Lim S. , Sala C. , Yoon J. , Park S. , Kuroda S. , Sheng M. , Kim E.
Mol. Cell. Neurosci.17:385-397(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHARPIN
9.

"Regulation of dendritic spine morphology and synaptic function by Shank and Homer."
Sala C. , Piech V. , Wilson N.R. , Passafaro M. , Liu G. , Sheng M.
Neuron31:115-130(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The Shank family of scaffold proteins."
Sheng M. , Kim E.
J. Cell Sci.113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
Shi S.-H. , Cheng T. , Jan L.Y. , Jan Y.-N.
Proc. Natl. Acad. Sci. U.S.A.101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGSF9
12.

"Paralemmin-1, a modulator of filopodia induction is required for spine maturation."
Arstikaitis P. , Gauthier-Campbell C. , Carolina Gutierrez Herrera R. , Huang K. , Levinson J.N. , Murphy T.H. , Kilimann M.W. , Sala C. , Colicos M.A. , El-Husseini A.
Mol. Biol. Cell19:2026-2038(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization."
Im Y.J. , Lee J.H. , Park S.H. , Park S.J. , Rho S.-H. , Kang G.B. , Kim E. , Eom S.H.
J. Biol. Chem.278:48099-48104(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 654-762 IN COMPLEX WITH DLGAP1;SUBUNIT

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