Protein name:
Signaling lymphocytic activation molecule ;
Alternative:
CD:
CD150 ;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1 (By similarity). Interacts with canine distemper virus HN protein; suggesting that it may serve as a receptor.
Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Present on the surface of B-cells and T-cells.
Protein Attributes:
50:
MDSRGFLSLR | CLLVLALASK | LSCGTGESLM | NCPEVPGKLG | SSLQLSLASE |
100:
GISKRMNKSI | HILVTRAESP | GNSIKKKIVS | LDLPEGGSPR | YLENGYKFHL |
150:
ENLTLRILES | RRENEGWYFM | TLEENFSVQH | FCLQLKLYEQ | VSTPEIKVLN |
200:
WTQENGNCSM | MLACEVEKGD | NVVYSWSEKL | GIDPLIPANS | SHLLHLSLGP |
250:
QHVNNVYVCT | VSNPVSNRSW | SFNPWSKCRP | ESSVPRQWRL | YAGLFLGGIV |
300:
GVILIFEVVL | LLLRRRGKTN | HYKPTKEEKS | LTIYAQVQKS | GSTQKKPDPL |
342:
PAEDPCTTIY | VAATEPVPEP | APEPVQEPHS | ITVYASVTFP | ES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Mouse
ELISA Kit for Dog Signaling lymphocytic activation molecule
ELISA Kit for Dog Signaling lymphocytic activation molecule
ELISA Kit for Dog Signaling lymphocytic activation molecule
CLIA Kit for Dog Signaling lymphocytic activation molecule
CLIA Kit for Dog Signaling lymphocytic activation molecule
CLIA Kit for Dog Signaling lymphocytic activation molecule
Polyclonal Antibody for Dog Signaling lymphocytic activation molecule
Polyclonal Antibody for Dog Signaling lymphocytic activation molecule
Polyclonal Antibody for Dog Signaling lymphocytic activation molecule
Monoclonal Antibody for Dog Signaling lymphocytic activation molecule
Monoclonal Antibody for Dog Signaling lymphocytic activation molecule
Monoclonal Antibody for Dog Signaling lymphocytic activation molecule
Protein for Dog Signaling lymphocytic activation molecule
Protein for Dog Signaling lymphocytic activation molecule
Protein for Dog Signaling lymphocytic activation molecule
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH CANINE DISTEMPER VIRUS HN PROTEIN
2.
"CD150 is a cellular receptor for canine distemper virus."
Richardson C.D.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]