SMAD4 CLIA Kit for Human(Homo sapiens) | EIAab.comSMAD4 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > SMAD4(Gene name) > Human

SMAD4 (Gene name),

Mothers against decapentaplegic homolog 4 (Protein name ), SMAD4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SMAD4(DPC4;MADH4);

Protein name:

Mothers against decapentaplegic homolog 4(MAD homolog 4;Mothers against DPP homolog 4);

Alternative:

SMAD family member 4(SMAD 4;Smad4;hSMAD4);Deletion target in pancreatic carcinoma 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CITED2 (By similarity). Monomer; in the absence of TGF-beta activation. Heterodimer; on TGF-beta activation. Composed of two molecules of a C-terminally phosphorylated R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the transcriptional active SMAD2/SMAD3-SMAD4 complex. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Interacts with ZNF423; the interaction takes place in response to BMP2 leading to activation of transcription of BMP target genes. Interacts with ZNF521; the interaction takes place in response to BMP2 leading to activation of transcription of BMP target genes. Interacts with USP9X. Interacts (via the MH1 and MH2 domains) with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. Interacts with CITED1.

Function:

Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD.

Protein Attributes:

Sequence length:

552

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

552:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q13485

KEGG:

hsa:4089

UniGene:

Hs.75862

MIM:

114500

String:

Q13485

Pfam:

PF03165

STRING:

9606.ENSP00000341551

Uniprot:

Q13485

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ELISA Kit for Human MAD homolog 4

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ELISA Kit for Human MAD homolog 4

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E1925r

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96T

ELISA Kit for Human MAD homolog 4

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E1925b

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96T

ELISA Kit for Human MAD homolog 4

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E1925m

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96T

ELISA Kit for Human MAD homolog 4

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E1925p

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96T

CLIA Kit for Human MAD homolog 4

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U1925m

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96T

CLIA Kit for Human MAD homolog 4

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U1925b

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96T

CLIA Kit for Human MAD homolog 4

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U1925h

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96T

CLIA Kit for Human MAD homolog 4

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U1925p

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96T

CLIA Kit for Human MAD homolog 4

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U1925r

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96T

Polyclonal Antibody for Human MAD homolog 4

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P1925Rb-r

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Polyclonal Antibody for Human MAD homolog 4

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P1925Rb-h

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Polyclonal Antibody for Human MAD homolog 4

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P1925Rb-m

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Monoclonal Antibody for Human MAD homolog 4

Protein for Human MAD homolog 4

R&D Technical Data

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Precision

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Linearity

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References

1.

"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1."
Hahn S.A. , Schutte M. , Shamsul Hoque A.T.M. , Moskaluk C.A. , da Costa L.T. , Rozenblum E. , Weinstein C.L. , Fischer A. , Yeo C.J. , Hruban R.H. , Kern S.E.
Science271:350-353(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT PANCREATIC CARCINOMA HIS-493
tissue: Fetal brain.
2.

"Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."
Zhang Y. , Feng X.-H. , Wu R.-Y. , Derynck R.
Nature383:168-172(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
3.

"Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma."
Moskaluk C.A. , Hruban R.H. , Schutte M. , Lietman A.S. , Smyrk T. , Fusaro L. , Fusaro R. , Lynch J. , Yeo C.J. , Jackson C.E. , Lynch H.T. , Kern S.E.
Diagn. Mol. Pathol.6:85-90(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Muscle.
7.

"Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes."
Liu F. , Pouponnot C. , Massague J.
Genes Dev.11:3157-3167(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors."
Kawabata M. , Inoue H. , Hanyu A. , Imamura T. , Miyazono K.
EMBO J.17:4056-4065(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
9.

"Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator."
Shioda T. , Lechleider R.J. , Dunwoodie S.L. , Li H. , Yahata T. , de Caestecker M.P. , Fenner M.H. , Roberts A.B. , Isselbacher K.J.
Proc. Natl. Acad. Sci. U.S.A.95:9785-9790(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED1
10.

"OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways."
Hata A. , Seoane J. , Lagna G. , Montalvo E. , Hemmati-Brivanlou A. , Massague J.
Cell100:229-240(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF423
11.

"The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain."
de Caestecker M.P. , Yahata T. , Wang D. , Parks W.T. , Huang S. , Hill C.S. , Shioda T. , Roberts A.B. , Lechleider R.J.
J. Biol. Chem.275:2115-2122(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF SAD DOMAIN
12.

"LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1."
Smith D.P. , Rayter S.I. , Niederlander C. , Spicer J. , Jones C.M. , Ashworth A.
Hum. Mol. Genet.10:2869-2877(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A TERNARY COMPLEX COMPOSED OF STK11/LKB1 AND STK11IP;INTERACTION WITH STK11/LKB1 AND STK11IP
13.

"Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation."
Wan M. , Cao X. , Wu Y. , Bai S. , Wu L. , Shi X. , Wang N. , Cao X.
EMBO Rep.3:171-176(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
14.

"TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling."
Felici A. , Wurthner J.U. , Parks W.T. , Giam L.R. , Reiss M. , Karpova T.S. , McNally J.G. , Roberts A.B.
EMBO J.22:4465-4477(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VPS39
15.

"DACH1 inhibits transforming growth factor-beta signaling through binding Smad4."
Wu K. , Yang Y. , Wang C. , Davoli M.A. , D'Amico M. , Li A. , Cveklova K. , Kozmik Z. , Lisanti M.P. , Russell R.G. , Cvekl A. , Pestell R.G.
J. Biol. Chem.278:51673-51684(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DACH1
16.

"Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells."
Bond H.M. , Mesuraca M. , Carbone E. , Bonelli P. , Agosti V. , Amodio N. , De Rosa G. , Di Nicola M. , Gianni A.M. , Moore M.A. , Hata A. , Grieco M. , Morrone G. , Venuta S.
Blood103:2062-2070(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF521
17.

"Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase."
Dupont S. , Zacchigna L. , Cordenonsi M. , Soligo S. , Adorno M. , Rugge M. , Piccolo S.
Cell121:87-99(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM33
18.

"Nuclear targeting of transforming growth factor-beta-activated Smad complexes."
Chen H.B. , Rud J.G. , Lin K. , Xu L.
J. Biol. Chem.280:21329-21336(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
19.

"Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS."
Sun Y. , Ding L. , Zhang H. , Han J. , Yang X. , Yan J. , Zhu Y. , Li J. , Song H. , Ye Q.
Nucleic Acids Res.34:6314-6326(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBPMS
20.

"3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins."
Seong H.A. , Jung H. , Kim K.T. , Ha H.
J. Biol. Chem.282:12272-12289(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION BY PDPK1;INTERACTION WITH PDPK1
21.

"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal."
Varelas X. , Sakuma R. , Samavarchi-Tehrani P. , Peerani R. , Rao B.M. , Dembowy J. , Yaffe M.B. , Zandstra P.W. , Wrana J.L.
Nat. Cell Biol.10:837-848(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWTR1
22.

"FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination."
Dupont S. , Mamidi A. , Cordenonsi M. , Montagner M. , Zacchigna L. , Adorno M. , Martello G. , Stinchfield M.J. , Soligo S. , Morsut L. , Inui M. , Moro S. , Modena N. , Argenton F. , Newfeld S.J. , Piccolo S.
Cell136:123-135(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP9X;UBIQUITINATION;MUTAGENESIS OF LYS-519
23.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-37; LYS-428 AND LYS-507;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension."
Nasim M.T. , Ogo T. , Ahmed M. , Randall R. , Chowdhury H.M. , Snape K.M. , Bradshaw T.Y. , Southgate L. , Lee G.J. , Jackson I. , Lord G.M. , Gibbs J.S. , Wilkins M.R. , Ohta-Ogo K. , Nakamura K. , Girerd B. , Coulet F. , Soubrier F. , more...
Hum. Mutat.32:1385-1389(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN PULMONARY HYPERTENSION;VARIANT SER-13
26.

"A structural basis for mutational inactivation of the tumour suppressor Smad4."
Shi Y. , Hata A. , Lo R.S. , Massague J. , Pavletich N.P.
Nature388:87-93(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 319-543
27.

"Crystal structure of a transcriptionally active Smad4 fragment."
Qin B. , Lam S.S. , Lin K.
Structure7:1493-1503(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 285-552
28.

"The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization."
Chacko B.M. , Qin B. , Correia J.J. , Lam S.S. , de Caestecker M.P. , Lin K.
Nat. Struct. Biol.8:248-253(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS) OF 273-552 OF WILD TYPE AND MUTANTS ARG-416; ARG-502 AND ARG-515 IN COMPLEX WITH SMAD3;SUBUNIT;MUTAGENESIS OF ARG-416; ARG-502 AND ARG-515
29.

"Structural basis of heteromeric smad protein assembly in TGF-beta signaling."
Chacko B.M. , Qin B.Y. , Tiwari A. , Shi G. , Lam S. , Hayward L.J. , De Caestecker M. , Lin K.
Mol. Cell15:813-823(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 314-552 IN COMPLEX WITH SMAD2 OR SMAD3;SUBUNIT
30.

"Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases."
Houlston R. , Bevan S. , Williams A. , Young J. , Dunlop M. , Rozen P. , Eng C. , Markie D. , Woodford-Richens K. , Rodriguez-Bigas M.A. , Leggett B. , Neale K. , Phillips R. , Sheridan E. , Hodgson S. , Iwama T. , Eccles D. , Bodmer W. , more...
Hum. Mol. Genet.7:1907-1912(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT JPS CYS-361
31.

"Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis."
Sayed M.G. , Ahmed A.F. , Ringold J.R. , Anderson M.E. , Bair J.L. , Mitros F.A. , Lynch H.T. , Tinley S.T. , Petersen G.M. , Giardiello F.M. , Vogelstein B. , Howe J.R.
Ann. Surg. Oncol.9:901-906(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS JPS GLY-330 AND ARG-352
32.

"A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)."
Gallione C.J. , Repetto G.M. , Legius E. , Rustgi A.K. , Schelley S.L. , Tejpar S. , Mitchell G. , Drouin E. , Westermann C.J.J. , Marchuk D.A.
Lancet363:852-859(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS JP/HHT ARG-352 AND ASP-386
33.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-130; ASN-351 AND HIS-361
34.

"A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome."
Caputo V. , Cianetti L. , Niceta M. , Carta C. , Ciolfi A. , Bocchinfuso G. , Carrani E. , Dentici M.L. , Biamino E. , Belligni E. , Garavelli L. , Boccone L. , Melis D. , Andria G. , Gelb B.D. , Stella L. , Silengo M. , Dallapiccola B. , more...
Am. J. Hum. Genet.90:161-169(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MYHRS THR-500 AND VAL-500
35.

"Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome."
Le Goff C. , Mahaut C. , Abhyankar A. , Le Goff W. , Serre V. , Afenjar A. , Destree A. , di Rocco M. , Heron D. , Jacquemont S. , Marlin S. , Simon M. , Tolmie J. , Verloes A. , Casanova J.L. , Munnich A. , Cormier-Daire V.
Nat. Genet.44:85-88(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MYHRS MET-500; THR-500 AND VAL-500;CHARACTERIZATION OF VARIANT MYHRS THR-500

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