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Index > Protein center > Smc4(Gene name) > Mouse
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  • Smc4 (Gene name),
  • Structural maintenance of chromosomes protein 4 (Protein name ),  SMC4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Smc4(Capc;Smc4l1);
    Protein name:
    Structural maintenance of chromosomes protein 4(SMC protein 4;SMC-4);
    Alternative:
    XCAP-C homolog;Chromosome-associated polypeptide C;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
    Function:
    Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
    Subcellular Location:
    Nucleus Cytoplasm Chromosome In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
    Protein Attributes:
    Sequence length:
    1286
    Sequence:
    50:
    MRRKGTKPST | ACHQEEGPPP | SQDGAHSDEE | MEQPAGEAES | AAPAKPPGEE | 
    100:
    LDNRSLEEIL | NSIPPPPPPA | MASEAGAPRL | MITHIVNQNF | KSYAGEKVLG | 
    150:
    PFHKRFSCII | GPNGSGKSNV | IDSMLFVFGY | RAQKIRSKKL | SVLIHNSDEH | 
    200:
    KDIQSCTVEV | HFQKIIDKEG | DDYEVLPNSN | FYVSRTAYRD | STSVYHISGK | 
    250:
    KKTFKDVGNL | LRSHGIDLDH | NRFLILQGEV | EQIAMMKPKG | QTEHDEGMLE | 
    300:
    YLEDIIGCGR | LNEPIKVLCR | RVEILNEHRG | EKLNRVKMVE | KEKDALEGEK | 
    350:
    NIAIEFLTLE | NEMFKKKNHI | CQYYIYDLQN | RIAEITTQKE | KIHEDTKEIT | 
    400:
    EKSNVLSNEM | KAKNSAVKDV | EKKLNKVTKF | IEQNKEKFTQ | LDLEDVQVRE | 
    450:
    KLKHATSKAK | KLEKQLQKDK | EKVEELKSVP | AKSKTVINET | TTRNNSLEKE | 
    500:
    REKEEKKLKE | VMDSLKQETQ | GLQKEKEIQE | KELMGFNKSV | NEARSKMEVA | 
    550:
    QSELDIYLSR | HNTAVSQLSK | AKEALITASE | TLKERKAAIK | DINTKLPQTQ | 
    600:
    QELKEKEKEL | QKLTQEEINL | KSLVHDLFQK | VEEAKSSLAM | NRSRGKVLDA | 
    650:
    IIQEKKSGRI | PGIYGRLGDL | GAIDEKYDIA | ISSCCHALDY | IVVDSIDTAQ | 
    700:
    ECVNFLKKHN | IGIATFIGLD | KMTVWAKKMS | KIQTPENTPR | LFDLVKVKNE | 
    750:
    EIRQAFYFAL | RDTLVANNLD | QATRVAYQRD | RRWRVVTLQG | QIIEQSGTMS | 
    800:
    GGGSKVMRGR | MGSSVIDEIS | VEEVNKMESQ | LERHSKQAMQ | IQEQKVQHEE | 
    850:
    AVVKLRHSER | DMRNTLEKFA | ASIQGLSEQE | EYLCVQIKEL | EANVLTTAPD | 
    900:
    RKQQKLLEEN | VSVFKKEYDA | VAEKAGKVEA | EIKRLHNTII | DINNRKLKAQ | 
    950:
    QNKLDTINKQ | LDECASAITK | AQVAIKTADR | NLKKAQDSVC | RTEKEIKDTE | 
    1000:
    KEINDLKTEL | KNIEDKAEEV | INNTKTAETS | LPEIQKEHRN | LLQELKVIQE | 
    1050:
    NEHALQKDAL | SIKLKLEQID | GHISEHNSKI | KYWQKEISKI | KLHPVEDNPV | 
    1100:
    ETVAVLSQEE | LEAIKNPESI | TNEIALLEAQ | CREMKPNLGA | IAEYKKKEDL | 
    1150:
    YLQRVAELDK | ITSERDNFRQ | AYEDLRKQRL | NEFMAGFYVI | TNKLKENYQM | 
    1200:
    LTLGGDAELE | LVDSLDPFSE | GIMFSVRPPK | KSWKKIFNLS | GGEKTLSSLA | 
    1250:
    LVFALHHYKP | TPLYFMDEID | AALDFKNVSI | VAFYIYEQTK | NAQFIIISLR | 
    1286:
    NNMFEISDRL | IGIYKTYNST | KSVAVNPKQI | ASKGLC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SMC protein 4
    Cat.:
    E3349h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse SMC protein 4
    Cat.:
    E3349m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SMC protein 4
    Cat.:
    U3349m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SMC protein 4
    Cat.:
    U3349h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse SMC protein 4
    Cat.:
    P3349Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SMC protein 4
    Cat.:
    P3349Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse SMC protein 4
    Monoclonal Antibody for Mouse SMC protein 4
    Protein for Mouse SMC protein 4
    Protein for Mouse SMC protein 4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The evolution of SMC proteins: phylogenetic analysis and structural implications."
      Cobbe N. , Heck M.M.S.
      Mol. Biol. Evol.21:332-347(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: C57BL/6J.
      tissue: Brain.
      tissue: Mammary tumor.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-602
      strain: NOD.
      tissue: Thymus.
    4. 4.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-379;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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