Mapt CLIA Kit for Mouse(Mus musculus) | EIAab.comMapt CLIA Kit for Mouse(Mus musculus)

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Index > Protein center > Mapt(Gene name) > Mouse

Mapt (Gene name),

Microtubule-associated protein tau (Protein name ), TAU_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapt(Mtapt;Tau);

Protein name:

Microtubule-associated protein tau;

Alternative:

Paired helical filament-tau(PHF-tau);Neurofibrillary tangle protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1. Interacts with FKBP4.

Function:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subcellular Location:

Cytoplasm cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Cell projection axon Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Protein Attributes:

Sequence length:

733

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

733:

SNVSSTGSID | MVDSPQLATL | ADEVSASLAK | QGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00418

String:

P10637

KEGG:

mmu:17762

UniGene:

Mm.1287

Uniprot:

P10637

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ELISA Kit for Mouse Microtubule-associated protein tau

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E1983h

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ELISA Kit for Mouse Microtubule-associated protein tau

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E1983r

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96T

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ELISA Kit for Mouse Microtubule-associated protein tau

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E1983m

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ELISA Kit for Mouse Microtubule-associated protein tau

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E1983b

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96T

CLIA Kit for Mouse Microtubule-associated protein tau

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U1983h

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CLIA Kit for Mouse Microtubule-associated protein tau

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U1983m

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CLIA Kit for Mouse Microtubule-associated protein tau

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U1983b

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96T

CLIA Kit for Mouse Microtubule-associated protein tau

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U1983r

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96T

Polyclonal Antibody for Mouse Microtubule-associated protein tau

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P1983Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Microtubule-associated protein tau

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P1983Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Microtubule-associated protein tau

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P1983Rb-h

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Monoclonal Antibody for Mouse Microtubule-associated protein tau

Protein for Mouse Microtubule-associated protein tau

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Primary structure of high molecular weight tau present in the peripheral nervous system."
Couchie D. , Mavilia C. , Georgieff I.S. , Liem R.K.H. , Shelanski M.L. , Nunez J.
Proc. Natl. Acad. Sci. U.S.A.89:4378-4381(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PNS-TAU)
tissue: Neuroblastoma.
2.

"Expression of three- and four-repeat tau isoforms in mouse liver."
Kenner L. , el-Shabrawi Y. , Hutter H. , Forstner M. , Zatloukal K. , Hoefler G. , Preisegger K.-H. , Kurzbauer R. , Denk H.
Hepatology20:1086-1089(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-A; TAU-D AND TAU-E)
strain: Him OF1.
tissue: Brain.
tissue: Kidney.
tissue: Liver.
3.

"The primary structure and heterogeneity of tau protein from mouse brain."
Lee G. , Cowan N.J. , Kirschner M.
Science239:285-288(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-B AND TAU-C)
tissue: Brain.
4.

"Molecular diversity at the carboxyl terminus of human and rat tau."
Sawa A. , Oyama F. , Matsushita M. , Ihara Y.
Brain Res. Mol. Brain Res.27:111-117(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM TAU-B)
strain: ICR.
tissue: Brain.
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TAU-D)
tissue: Eye.
7.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 504-513; 535-546; 591-609 AND 646-661;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
8.

"High molecular weight tau proteins and acquisition of neuronal polarity in peripheral nervous system."
Couchie D. , Gache Y. , Mavilia C. , Guilleminot J. , Bridoux A.-M. , Nivez M.-P. , Nunez J.
C. R. Acad. Sci. III, Sci. Vie316:404-409(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
9.

"Phosphorylation of tau by fyn: implications for Alzheimer's disease."
Lee G. , Thangavel R. , Sharma V.M. , Litersky J.M. , Bhaskar K. , Fang S.M. , Do L.H. , Andreadis A. , Van Hoesen G. , Ksiezak-Reding H.
J. Neurosci.24:2304-2312(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FYN
10.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
11.

"Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation."
Babu J.R. , Geetha T. , Wooten M.W.
J. Neurochem.94:192-203(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMC2
12.

"Mammalian SAD kinases are required for neuronal polarization."
Kishi M. , Pan Y.A. , Crump J.G. , Sanes J.R.
Science307:929-932(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-554
13.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
14.

"LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons."
Barnes A.P. , Lilley B.N. , Pan Y.A. , Plummer L.J. , Powell A.W. , Raines A.N. , Sanes J.R. , Polleux F.
Cell129:549-563(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-554
15.

"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain cortex.
16.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494; SER-688; SER-692 AND SER-696;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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