Trim72 CLIA Kit for Mouse(Mus musculus) | EIAab.comTrim72 CLIA Kit for Mouse(Mus musculus)

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Trim72 (Gene name),

Tripartite motif-containing protein 72 (Protein name ), TRI72_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Trim72(Mg53);

Protein name:

Tripartite motif-containing protein 72;

Alternative:

Mitsugumin-53(Mg53);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homooligomer; disulfide-linked. Interacts with DYSF and CAV3.

Function:

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Subcellular Location:

Cell membrane sarcolemma Cytoplasmic vesicle membrane Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.

Protein Attributes:

Sequence length:

477

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

477:

PIFDVCWHDK | GKNAQPLLLV | GPEQEQA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q1XH17

STRING:

10090.ENSMUSP00000079832

UniGene:

Mm.389924

Pfam:

PF00622

Pfam:

PF13765

SMR:

Q1XH17

KEGG:

mmu:434246

Uniprot:

Q1XH17

FOR

ELISA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

E3671r

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96T

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ELISA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

E3671h

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96T

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ELISA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

E3671m

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ELISA Kit for Mouse Tripartite motif-containing protein 72

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CLIA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

U3671r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

U3671h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Tripartite motif-containing protein 72

Cat.:

U3671m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Tripartite motif-containing protein 72

MSDS:

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Polyclonal Antibody for Mouse Tripartite motif-containing protein 72

Cat.:

P3671Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tripartite motif-containing protein 72

Cat.:

P3671Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tripartite motif-containing protein 72

Cat.:

P3671Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Tripartite motif-containing protein 72

Protein for Mouse Tripartite motif-containing protein 72

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"MG53 nucleates assembly of cell membrane repair machinery."
Cai C. , Masumiya H. , Weisleder N. , Matsuda N. , Nishi M. , Hwang M. , Ko J.-K. , Lin P. , Thornton A. , Zhao X. , Pan Z. , Komazaki S. , Brotto M. , Takeshima H. , Ma J.
Nat. Cell Biol.11:56-64(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;PHOSPHATIDYLSERINE-BINDING;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DISULFIDE BOND AT CYS-242;MUTAGENESIS OF CYS-14; CYS-17; CYS-29; CYS-34; CYS-37; CYS-53; CYS-55; CYS-56; CYS-86; CYS-97; CYS-105; CYS-108; CYS-144; CYS-242; CYS-313 AND CYS-456
strain: C57BL/6J.
tissue: Skeletal muscle.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Jaw.
tissue: Limb.
3.

"Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes."
Masumiya H. , Asaumi Y. , Nishi M. , Minamisawa S. , Adachi-Akahane S. , Yoshida M. , Kangawa K. , Ito K. , Kagaya Y. , Yanagisawa T. , Yamazaki T. , Ma J. , Takeshima H.
Channels3:6-11(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"MG53 regulates membrane budding and exocytosis in muscle cells."
Cai C. , Masumiya H. , Weisleder N. , Pan Z. , Nishi M. , Komazaki S. , Takeshima H. , Ma J.
J. Biol. Chem.284:3314-3322(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
5.

"Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin."
Cai C. , Weisleder N. , Ko J.-K. , Komazaki S. , Sunada Y. , Nishi M. , Takeshima H. , Ma J.
J. Biol. Chem.284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DYSF AND CAV3

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