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Index > Protein center > UCP3(Gene name) > Human
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  • UCP3 (Gene name),
  • Mitochondrial uncoupling protein 3 (Protein name ),  UCP3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    UCP3(SLC25A9);
    Protein name:
    Mitochondrial uncoupling protein 3(UCP 3);
    Alternative:
    Solute carrier family 25 member 9;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
    Subcellular Location:
    Mitochondrion inner membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    312
    Sequence:
    50:
    MVGLKPSDVP | PTMAVKFLGA | GTAACFADLV | TFPLDTAKVR | LQIQGENQAV | 
    100:
    QTARLVQYRG | VLGTILTMVR | TEGPCSPYNG | LVAGLQRQMS | FASIRIGLYD | 
    150:
    SVKQVYTPKG | ADNSSLTTRI | LAGCTTGAMA | VTCAQPTDVV | KVRFQASIHL | 
    200:
    GPSRSDRKYS | GTMDAYRTIA | REEGVRGLWK | GTLPNIMRNA | IVNCAEVVTY | 
    250:
    DILKEKLLDY | HLLTDNFPCH | FVSAFGAGFC | ATVVASPVDV | VKTRYMNSPP | 
    300:
    GQYFSPLDCM | IKMVAQEGPT | AFYKGFTPSF | LRLGSWNVVM | FVTYEQLKRA | 
    312:
    LMKVQMLRES | PF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human UCP 3
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    E2068r
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    96T
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    ELISA Kit for Human UCP 3
    Cat.:
    E2068b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human UCP 3
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    E2068h
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    96T
    ELISA Kit for Human UCP 3
    Cat.:
    E2068m
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    96T
    ELISA Kit for Human UCP 3
    Cat.:
    E2068p
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    MSDS:
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    96T
    ELISA Kit for Human UCP 3
    Cat.:
    E2068d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 3
    Cat.:
    U2068b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 3
    Cat.:
    U2068m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 3
    Cat.:
    U2068r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human UCP 3
    Cat.:
    U2068p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UCP 3
    Cat.:
    U2068d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 3
    Cat.:
    U2068h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human UCP 3
    Cat.:
    P2068Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 3
    Polyclonal Antibody for Human UCP 3
    Polyclonal Antibody for Human UCP 3
    Cat.:
    P2068Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 3
    Cat.:
    P2068Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Monoclonal Antibody for Human UCP 3
    Protein for Human UCP 3
    Protein for Human UCP 3
    Protein for Human UCP 3
    Protein for Human UCP 3
    Protein for Human UCP 3
    Protein for Human UCP 3

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    Linearity
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    References
    1. 1.
      "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression."
      Boss O. , Samec S. , Paoloni-Giacobino A. , Dulloo A. , Seydoux J. , Rossier C. , Muzzin P. , Giacobino J.-P.
      FEBS Lett.408:39-42(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
    2. 2.
      "The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts."
      Solanes G. , Vidal-Puig A. , Grujic D. , Flier J.S. , Lowell B.B.
      J. Biol. Chem.272:25433-25436(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS UCP3L AND UCP3S)
    3. 3.
      "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue."
      Vidal-Puig A. , Solanes G. , Grujic D. , Flier J.S. , Lowell B.B.
      Biochem. Biophys. Res. Commun.235:79-82(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM UCP3L);TISSUE SPECIFICITY
    4. 4.
      "Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin."
      Gong D.-W. , He Y. , Karas M. , Reitman M.
      J. Biol. Chem.272:24129-24132(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity."
      Urhammer S.A. , Dalgaard L.T. , Soerensen T.I.A. , Tybjaerg-Hansen A. , Echwald S.M. , Andersen T. , Clausen J.O. , Pedersen O.
      Diabetologia41:241-244(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents."
      Esterbauer H. , Oberkofler H. , Krempler F. , Strosberg A.D. , Patsch W.
      J. Biol. Chem.275:36394-36399(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Skeletal muscle.
    8. 8.
      "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes."
      Argyropoulos G. , Brown A.M. , Willi S.M. , Zhu J. , He Y. , Reitman M. , Gevao S.M. , Spruill I. , Garvey W.T.
      J. Clin. Invest.102:1345-1351(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY ILE-102
    9. 9.
      "A novel missense mutation, R70W, in the human uncoupling protein 3 gene in a family with type 2 diabetes."
      Brown A.M. , Willi S.M. , Argyropoulos G. , Garvey W.T.
      Hum. Mutat.13:506-506(1999)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY TRP-70
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