Protein name:
Dual specificity protein kinase CLK2 ;
Alternative:
CDC-like kinase 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RBMX. Interacts with AKT1 and UBL5.
Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Subcellular Location:
Isoform 2
Nucleus speckle
Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
Protein Attributes:
50:
MPHPRRYHSS | ERGSRGSYRE | HYRSRKHKRR | RSRSWSSSSD | RTRRRRREDS |
100:
YHVRSRSSYD | DRSSDRRVYD | RRYCGSYRRN | DYSRDRGDAY | YDTDYRHSYE |
150:
YQRENSSYRS | QRSSRRKHRR | RRRRSRTFSR | SSSQHSSRRA | KSVEDDAEGH |
200:
LIYHVGDWLQ | ERYEIVSTLG | EGTFGRVVQC | VDHRRGGARV | ALKIIKNVEK |
250:
YKEAARLEIN | VLEKINEKDP | DNKNLCVQMF | DWFDYHGHMC | ISFELLGLST |
300:
FDFLKDNNYL | PYPIHQVRHM | AFQLCQAVKF | LHDNKLTHTD | LKPENILFVN |
350:
SDYELTYNLE | KKRDERSVKS | TAVRVVDFGS | ATFDHEHHST | IVSTRHYRAP |
400:
EVILELGWSQ | PCDVWSIGCI | IFEYYVGFTL | FQTHDNREHL | AMMERILGPI |
450:
PSRMIRKTRK | QKYFYRGRLD | WDENTSAGRY | VRENCKPLRR | YLTSEAEEHH |
499:
QLFDLIESML | EYEPAKRLTL | GEALQHPFFA | RLRAEPPNKL | WDSSRDISR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Dual specificity protein kinase CLK2
ELISA Kit for Human Dual specificity protein kinase CLK2
CLIA Kit for Human Dual specificity protein kinase CLK2
CLIA Kit for Human Dual specificity protein kinase CLK2
Polyclonal Antibody for Human Dual specificity protein kinase CLK2
Polyclonal Antibody for Human Dual specificity protein kinase CLK2
Monoclonal Antibody for Human Dual specificity protein kinase CLK2
Monoclonal Antibody for Human Dual specificity protein kinase CLK2
Protein for Human Dual specificity protein kinase CLK2
Protein for Human Dual specificity protein kinase CLK2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Lung .
tissue :
Ovary .
5.
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Cited for : FUNCTION
6.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION
7.
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Cited for : FUNCTION
8.
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Cited for : INTERACTION WITH UBL5
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RBMX
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND TYR-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-34 AND THR-127;INTERACTION WITH AKT1
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 135-496