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Index > Protein center > Clk3(Gene name) > Mouse
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  • Clk3 (Gene name),
  • Dual specificity protein kinase CLK3 (Protein name ),  CLK3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Clk3;
    Protein name:
    Dual specificity protein kinase CLK3;
    Alternative:
    CDC-like kinase 3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
    Subcellular Location:
    Nucleus Cytoplasm Cytoplasmic vesicle secretory vesicle acrosome
    Protein Attributes:
    Sequence length:
    638
    Sequence:
    50:
    MPVLSARRKR | LASTAGPRRG | SGPSLAVRWV | PPLGPEPSSD | RGRAPMRPRG | 
    100:
    PTCSTTRRGA | GRGPRLLPGP | PGRDLHRCRP | DPGGAGQSPR | VCEFGARAVR | 
    150:
    PLGRVEPGPP | TAASREGAVL | PRAEARAGSG | RGARSGEWGL | AAAGAWETMH | 
    200:
    HCKRYRSPEP | DPYLSYRWKR | RRSYSREHEG | RLRYPSRREP | PPRRSRSRSH | 
    250:
    DRIPYQRRYR | EHRDSDTYRC | EERSPSFGED | CYGSSRSRHR | RRSRERAPYR | 
    300:
    TRKHAHHCHK | RRTRSCSSAS | SRSQQSSKRS | SRSVEDDKEG | HLVCRIGDWL | 
    350:
    QERYEIVGNL | GEGTFGKVVE | CLDHARGKSQ | VALKIIRNVG | KYREAARLEI | 
    400:
    NVLKKIKEKD | KENKFLCVLM | SDWFNFHGHM | CIAFELLGKN | TFEFLKENNF | 
    450:
    QPYPLPHVRH | MAYQLCHALR | FLHENQLTHT | DLKPENILFV | NSEFETLYNE | 
    500:
    HKSCEEKSVK | NTSIRVADFG | SATFDHEHHT | TIVATRHYRP | PEVILELGWA | 
    550:
    QPCDVWSIGC | ILFEYYRGFT | LFQTHENREH | LVMMEKILGP | IPSHMIHRTR | 
    600:
    KQKYFYKGGL | VWDENSSDGR | YVKENCKPLK | SYMLQDSLEH | VQLFDLMRRM | 
    638:
    LEFDPAQRIT | LAEALLHPFF | AGLTPEERSF | HSSRNPSR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Dual specificity protein kinase CLK3
    ELISA Kit for Mouse Dual specificity protein kinase CLK3
    ELISA Kit for Mouse Dual specificity protein kinase CLK3
    ELISA Kit for Mouse Dual specificity protein kinase CLK3
    CLIA Kit for Mouse Dual specificity protein kinase CLK3
    CLIA Kit for Mouse Dual specificity protein kinase CLK3
    CLIA Kit for Mouse Dual specificity protein kinase CLK3
    CLIA Kit for Mouse Dual specificity protein kinase CLK3
    Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
    Protein for Mouse Dual specificity protein kinase CLK3
    Protein for Mouse Dual specificity protein kinase CLK3
    Protein for Mouse Dual specificity protein kinase CLK3
    Protein for Mouse Dual specificity protein kinase CLK3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Brain.
      tissue: Kidney.
      tissue: Placenta.
      tissue: Thymus.
      tissue: Tongue.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-638
      tissue: Olfactory epithelium.
    3. 3.
      "Characterization and comparison of four serine- and arginine-rich (SR) protein kinases."
      Nayler O. , Stamm S. , Ullrich A.
      Biochem. J.326:693-700(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-638;FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
    4. 4.
      "The dual specificity protein kinase CLK3 is abundantly expressed in mature mouse spermatozoa."
      Menegay H. , Moeslein F. , Landreth G.
      Exp. Cell Res.253:463-473(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
    5. 5.
      "Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing."
      Debdab M. , Carreaux F. , Renault S. , Soundararajan M. , Fedorov O. , Filippakopoulos P. , Lozach O. , Babault L. , Tahtouh T. , Baratte B. , Ogawa Y. , Hagiwara M. , Eisenreich A. , Rauch U. , Knapp S. , Meijer L. , Bazureau J.P.
      J. Med. Chem.54:4172-4186(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
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