Protein name:
Dual specificity protein kinase CLK3 ;
Alternative:
CDC-like kinase 3 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Subcellular Location:
Nucleus
Cytoplasm
Cytoplasmic vesicle
secretory vesicle
acrosome
Protein Attributes:
50:
MPVLSARRKR | LASTAGPRRG | SGPSLAVRWV | PPLGPEPSSD | RGRAPMRPRG |
100:
PTCSTTRRGA | GRGPRLLPGP | PGRDLHRCRP | DPGGAGQSPR | VCEFGARAVR |
150:
PLGRVEPGPP | TAASREGAVL | PRAEARAGSG | RGARSGEWGL | AAAGAWETMH |
200:
HCKRYRSPEP | DPYLSYRWKR | RRSYSREHEG | RLRYPSRREP | PPRRSRSRSH |
250:
DRIPYQRRYR | EHRDSDTYRC | EERSPSFGED | CYGSSRSRHR | RRSRERAPYR |
300:
TRKHAHHCHK | RRTRSCSSAS | SRSQQSSKRS | SRSVEDDKEG | HLVCRIGDWL |
350:
QERYEIVGNL | GEGTFGKVVE | CLDHARGKSQ | VALKIIRNVG | KYREAARLEI |
400:
NVLKKIKEKD | KENKFLCVLM | SDWFNFHGHM | CIAFELLGKN | TFEFLKENNF |
450:
QPYPLPHVRH | MAYQLCHALR | FLHENQLTHT | DLKPENILFV | NSEFETLYNE |
500:
HKSCEEKSVK | NTSIRVADFG | SATFDHEHHT | TIVATRHYRP | PEVILELGWA |
550:
QPCDVWSIGC | ILFEYYRGFT | LFQTHENREH | LVMMEKILGP | IPSHMIHRTR |
600:
KQKYFYKGGL | VWDENSSDGR | YVKENCKPLK | SYMLQDSLEH | VQLFDLMRRM |
638:
LEFDPAQRIT | LAEALLHPFF | AGLTPEERSF | HSSRNPSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Mouse Dual specificity protein kinase CLK3
ELISA Kit for Mouse Dual specificity protein kinase CLK3
ELISA Kit for Mouse Dual specificity protein kinase CLK3
ELISA Kit for Mouse Dual specificity protein kinase CLK3
CLIA Kit for Mouse Dual specificity protein kinase CLK3
CLIA Kit for Mouse Dual specificity protein kinase CLK3
CLIA Kit for Mouse Dual specificity protein kinase CLK3
CLIA Kit for Mouse Dual specificity protein kinase CLK3
Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
Polyclonal Antibody for Mouse Dual specificity protein kinase CLK3
Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
Monoclonal Antibody for Mouse Dual specificity protein kinase CLK3
Protein for Mouse Dual specificity protein kinase CLK3
Protein for Mouse Dual specificity protein kinase CLK3
Protein for Mouse Dual specificity protein kinase CLK3
Protein for Mouse Dual specificity protein kinase CLK3
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Brain .
tissue :
Kidney .
tissue :
Placenta .
tissue :
Thymus .
tissue :
Tongue .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-638
tissue :
Olfactory epithelium .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 141-638;FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
5.
"Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing."
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Knapp S.
,
Meijer L.
,
Bazureau J.P.
J. Med. Chem.54:4172-4186(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION