Clock ELISA Kit for Mouse(Mus musculus) | EIAab.comClock ELISA Kit for Mouse(Mus musculus)

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Clock (Gene name),

Circadian locomoter output cycles protein kaput (Protein name ), CLOCK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Clock;

Protein name:

Circadian locomoter output cycles protein kaput(mCLOCK);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with ARNTL is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Binds weakly ARNTL and ARNTL2 to form heterodimers which bind poorly to the E-box motif.

Function:

ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. Acetylates also a non-histone substrate: its own partner, ARNTL. Plays a role in DNA damage response (DDR) signaling during the S phase.

Subcellular Location:

Nucleus Chromosome Cytoplasm Localizes to sites of DNA damage in a H2AX-independent manner (By similarity). Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus predominantly between C12 and C21. Nonphosphorylated form found only in the cytoplasm.

Protein Attributes:

Sequence length:

855

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

855:

KVQPQ

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

KEGG:

mmu:12753

String:

O08785

SMR:

O08785

Pfam:

PF00010

UniGene:

Mm.3552

Uniprot:

O08785

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ELISA Kit for Mouse mCLOCK

Cat.:

E15436m

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MSDS:

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96T

ELISA Kit for Mouse mCLOCK

Cat.:

E15436r

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96T

ELISA Kit for Mouse mCLOCK

Cat.:

E15436c

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96T

ELISA Kit for Mouse mCLOCK

Cat.:

E15436h

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96T

CLIA Kit for Mouse mCLOCK

Cat.:

U15436r

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96T

CLIA Kit for Mouse mCLOCK

Cat.:

U15436c

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96T

CLIA Kit for Mouse mCLOCK

Cat.:

U15436h

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MSDS:

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96T

CLIA Kit for Mouse mCLOCK

Cat.:

U15436m

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MSDS:

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96T

Polyclonal Antibody for Mouse mCLOCK

Cat.:

P15436Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse mCLOCK

Cat.:

P15436Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse mCLOCK

Cat.:

P15436Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse mCLOCK

Monoclonal Antibody for Mouse mCLOCK

Protein for Mouse mCLOCK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Functional identification of the mouse circadian clock gene by transgenic BAC rescue."
Antoch M.P. , Song E.J. , Chang A.M. , Vitaterna M.H. , Zhao Y. , Wilsbacher L.D. , Sangoram A.M. , King D.P. , Pinto L.H. , Takahashi J.S.
Cell89:655-667(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
strain: 129.
2.

"Positional cloning of the mouse circadian clock gene."
King D.P. , Zhao Y. , Sangoram A.M. , Wilsbacher L.D. , Tanaka M. , Antoch M.P. , Steeves T.D.L. , Vitaterna M.H. , Kornhauser J.M. , Lowrey P.L. , Turek F.W. , Takahashi J.S.
Cell89:641-653(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT);TISSUE SPECIFICITY;IDENTIFICATION OF CLOCK VARIANT
strain: C57BL/6 X BALB/c.
tissue: Suprachiasmatic nucleus.
3.

"The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5."
Wilsbacher L.D. , Sangoram A.M. , Antoch M.P. , Takahashi J.S.
Genome Res.10:1928-1940(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
4.

"Role of the CLOCK protein in the mammalian circadian mechanism."
Gekakis N. , Staknis D. , Nguyen H.B. , Davis F.C. , Wilsbacher L.D. , King D.P. , Takahashi J.S. , Weitz C.J.
Science280:1564-1569(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARNTL
5.

"Posttranslational mechanisms regulate the mammalian circadian clock."
Lee C. , Etchegaray J.-P. , Cagampang F.R.A. , Loudon A.S.I. , Reppert S.M.
Cell107:855-867(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ARNTL; PER1; PER2; CRY1; CRY2; CSNK1D AND CSNK1E;PHOSPHORYLATION;SUBCELLULAR LOCATION;INDUCTION
6.

"BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system."
Kondratov R.V. , Chernov M.V. , Kondratova A.A. , Gorbacheva V.Y. , Gudkov A.V. , Antoch M.P.
Genes Dev.17:1921-1932(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARNTL;PHOSPHORYLATION;SUBCELLULAR LOCATION;INDUCTION
7.

"Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2."
Schoenhard J.A. , Smith L.H. , Painter C.A. , Eren M. , Johnson C.H. , Vaughan D.E.
J. Mol. Cell. Cardiol.35:473-481(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
Kawamoto T. , Noshiro M. , Sato F. , Maemura K. , Takeda N. , Nagai R. , Iwata T. , Fujimoto K. , Furukawa M. , Miyazaki K. , Honma S. , Honma K.I. , Kato Y.
Biochem. Biophys. Res. Commun.313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
10.

"Circadian regulator CLOCK is a histone acetyltransferase."
Doi M. , Hirayama J. , Sassone-Corsi P.
Cell125:497-508(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PRO-656; TYR-658; ASN-659; GLY-669; SER-670 AND VAL-672;FUNCTION;CATALYTIC ACTIVITY
11.

"The polycomb group protein EZH2 is required for mammalian circadian clock function."
Etchegaray J.P. , Yang X. , DeBruyne J.P. , Peters A.H. , Weaver D.R. , Jenuwein T. , Reppert S.M.
J. Biol. Chem.281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EZH2; ARNTL; PER1; PER2; CRY1 AND CRY2
12.

"BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer."
Kwon I. , Lee J. , Chang S.H. , Jung N.C. , Lee B.J. , Son G.H. , Kim K. , Lee K.H.
Mol. Cell. Biol.26:7318-7330(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH ARNTL;UBIQUITINATION;PROTEASOMAL DEGRADATION
13.

"CIPC is a mammalian circadian clock protein without invertebrate homologues."
Zhao W.N. , Malinin N. , Yang F.C. , Staknis D. , Gekakis N. , Maier B. , Reischl S. , Kramer A. , Weitz C.J.
Nat. Cell Biol.9:268-275(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH CIPC
14.

"CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock."
DeBruyne J.P. , Weaver D.R. , Reppert S.M.
Nat. Neurosci.10:543-545(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"CLOCK-mediated acetylation of BMAL1 controls circadian function."
Hirayama J. , Sahar S. , Grimaldi B. , Tamaru T. , Takamatsu K. , Nakahata Y. , Sassone-Corsi P.
Nature450:1086-1090(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACETYLATION OF ARNTL
16.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
17.

"Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK."
Langmesser S. , Tallone T. , Bordon A. , Rusconi S. , Albrecht U.
BMC Mol. Biol.9:41-41(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER2
18.

"SIRT1 regulates circadian clock gene expression through PER2 deacetylation."
Asher G. , Gatfield D. , Stratmann M. , Reinke H. , Dibner C. , Kreppel F. , Mostoslavsky R. , Alt F.W. , Schibler U.
Cell134:317-328(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SIRT1; ARNTL; PER2 AND CRY1
19.

"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control."
Nakahata Y. , Kaluzova M. , Grimaldi B. , Sahar S. , Hirayama J. , Chen D. , Guarente L.P. , Sassone-Corsi P.
Cell134:329-340(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT1
20.

"Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators."
Bertolucci C. , Cavallari N. , Colognesi I. , Aguzzi J. , Chen Z. , Caruso P. , Foa A. , Tosini G. , Bernardi F. , Pinotti M.
Mol. Cell. Biol.28:3070-3075(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation."
Spengler M.L. , Kuropatwinski K.K. , Schumer M. , Antoch M.P.
Cell Cycle8:4138-4146(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-427 AND SER-431;MUTAGENESIS OF SER-427 AND SER-431;INTERACTION WITH GSK3B AND ARNTL
22.

"Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications."
Nader N. , Chrousos G.P. , Kino T.
FASEB J.23:1572-1583(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NR3C1
23.

"Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription."
Sasaki M. , Yoshitane H. , Du N.H. , Okano T. , Fukada Y.
J. Biol. Chem.284:25149-25159(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription."
Yoshitane H. , Takao T. , Satomi Y. , Du N.H. , Okano T. , Fukada Y.
Mol. Cell. Biol.29:3675-3686(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;PHOSPHORYLATION AT SER-38; SER-42 AND SER-427;MUTAGENESIS OF SER-38; SER-42 AND SER-427
25.

"Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter."
Hara Y. , Onishi Y. , Oishi K. , Miyazaki K. , Fukamizu A. , Ishida N.
Nucleic Acids Res.37:1115-1126(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYBBP1A
26.

"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis."
Ramsey K.M. , Yoshino J. , Brace C.S. , Abrassart D. , Kobayashi Y. , Marcheva B. , Hong H.K. , Chong J.L. , Buhr E.D. , Lee C. , Takahashi J.S. , Imai S. , Bass J.
Science324:651-654(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1."
Nakahata Y. , Sahar S. , Astarita G. , Kaluzova M. , Sassone-Corsi P.
Science324:654-657(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2."
Doi R. , Oishi K. , Ishida N.
J. Biol. Chem.285:22114-22121(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
29.

"The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."
Ward S.M. , Fernando S.J. , Hou T.Y. , Duffield G.E.
J. Biol. Chem.285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ID1; ID2 AND ID3
30.

"Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver."
Guillaumond F. , Grechez-Cassiau A. , Subramaniam M. , Brangolo S. , Peteri-Brunback B. , Staels B. , Fievet C. , Spelsberg T.C. , Delaunay F. , Teboul M.
Mol. Cell. Biol.30:3059-3070(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
31.

"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes."
Marcheva B. , Ramsey K.M. , Buhr E.D. , Kobayashi Y. , Su H. , Ko C.H. , Ivanova G. , Omura C. , Mo S. , Vitaterna M.H. , Lopez J.P. , Philipson L.H. , Bradfield C.A. , Crosby S.D. , Je Bailey L. , Wang X. , Takahashi J.S. , Bass J.
Nature466:627-631(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
32.

"The histone methyltransferase MLL1 permits the oscillation of circadian gene expression."
Katada S. , Sassone-Corsi P.
Nat. Struct. Mol. Biol.17:1414-1421(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KMT2A
33.

"CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function."
Andrews J.L. , Zhang X. , McCarthy J.J. , McDearmon E.L. , Hornberger T.A. , Russell B. , Campbell K.S. , Arbogast S. , Reid M.B. , Walker J.R. , Hogenesch J.B. , Takahashi J.S. , Esser K.A.
Proc. Natl. Acad. Sci. U.S.A.107:19090-19095(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
34.

"cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene."
Koyanagi S. , Hamdan A.M. , Horiguchi M. , Kusunose N. , Okamoto A. , Matsunaga N. , Ohdo S.
J. Biol. Chem.286:32416-32423(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
35.

"Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype."
Somanath P.R. , Podrez E.A. , Chen J. , Ma Y. , Marchant K. , Antoch M. , Byzova T.V.
J. Cell. Physiol.226:132-140(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
36.

"The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1."
Lee H.M. , Chen R. , Kim H. , Etchegaray J.P. , Weaver D.R. , Lee C.
Proc. Natl. Acad. Sci. U.S.A.108:16451-16456(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CSNK1D AND CKSN1E
37.

"Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."
DiTacchio L. , Le H.D. , Vollmers C. , Hatori M. , Witcher M. , Secombe J. , Panda S.
Science333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5A
38.

"Diurnal expression of the thrombopoietin gene is regulated by CLOCK."
Tracey C.J. , Pan X. , Catterson J.H. , Harmar A.J. , Hussain M.M. , Hartley P.S.
J. Thromb. Haemost.10:662-669(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
39.

"Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome."
Stratmann M. , Suter D.M. , Molina N. , Naef F. , Schibler U.
Mol. Cell48:277-287(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
40.

"Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells."
Peruquetti R.L. , de Mateo S. , Sassone-Corsi P.
PLoS ONE7:E42695-E42695(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH EIF4E; PIWIL1 AND DDX4
41.

"Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription."
Spengler M.L. , Kuropatwinski K.K. , Comas M. , Gasparian A.V. , Fedtsova N. , Gleiberman A.S. , Gitlin I.I. , Artemicheva N.M. , Deluca K.A. , Gudkov A.V. , Antoch M.P.
Proc. Natl. Acad. Sci. U.S.A.109:E2457-E2465(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RELA/P65
42.

"A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention."
Richards J. , Cheng K.Y. , All S. , Skopis G. , Jeffers L. , Lynch I.J. , Wingo C.S. , Gumz M.L.
Am. J. Physiol.305:F1697-F1704(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER1;TISSUE SPECIFICITY
43.

"Mechanism of the circadian clock in physiology."
Richards J. , Gumz M.L.
Am. J. Physiol.304:R1053-R1064(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
44.

"The molecular clock regulates circadian transcription of tissue factor gene."
Oishi K. , Koyanagi S. , Ohkura N.
Biochem. Biophys. Res. Commun.431:332-335(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
45.

"Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock."
Kaasik K. , Kivimae S. , Allen J.J. , Chalkley R.J. , Huang Y. , Baer K. , Kissel H. , Burlingame A.L. , Shokat K.M. , Ptacek L.J. , Fu Y.H.
Cell Metab.17:291-302(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;INTERACTION WITH MGEA5
46.

"O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination."
Li M.D. , Ruan H.B. , Hughes M.E. , Lee J.S. , Singh J.P. , Jones S.P. , Nitabach M.N. , Yang X.
Cell Metab.17:303-310(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;UBIQUITINATION
47.

"A role for clock genes in sleep homeostasis."
Franken P.
Curr. Opin. Neurobiol.23:864-872(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
48.

"Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."
Kwak Y. , Jeong J. , Lee S. , Park Y.U. , Lee S.A. , Han D.H. , Kim J.H. , Ohshima T. , Mikoshiba K. , Suh Y.H. , Cho S. , Park S.K.
J. Biol. Chem.288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-451 AND THR-461;INTERACTION WITH THE COMPLEX P35/CDK5
49.

"Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration."
Musiek E.S. , Lim M.M. , Yang G. , Bauer A.Q. , Qi L. , Lee Y. , Roh J.H. , Ortiz-Gonzalez X. , Dearborn J.T. , Culver J.P. , Herzog E.D. , Hogenesch J.B. , Wozniak D.F. , Dikranian K. , Giasson B.I. , Weaver D.R. , Holtzman D.M. , Fitzgerald G.A.
J. Clin. Invest.123:5389-5400(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
50.

"p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
Baeza-Raja B. , Eckel-Mahan K. , Zhang L. , Vagena E. , Tsigelny I.F. , Sassone-Corsi P. , Ptacek L.J. , Akassoglou K.
J. Neurosci.33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
51.

"Metastasis-associated protein 1 is an integral component of the circadian molecular machinery."
Li D.Q. , Pakala S.B. , Reddy S.D. , Peng S. , Balasenthil S. , Deng C.X. , Lee C.C. , Rea M.A. , Kumar R.
Nat. Commun.4:2545-2545(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1
52.

"CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha."
Li S. , Wang M. , Ao X. , Chang A.K. , Yang C. , Zhao F. , Bi H. , Liu Y. , Xiao L. , Wu H.
Oncogene32:4883-4891(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-67 AND LYS-851;DESUMOYLATION;INTERACTION WITH ESR1;MUTAGENESIS OF LYS-67 AND LYS-851
53.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
54.

"Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells."
Gao Y. , Meng D. , Sun N. , Zhu Z. , Zhao R. , Lu C. , Chen S. , Hua L. , Qian R.
Biochem. Biophys. Res. Commun.443:586-591(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
55.

"CLOCK:BMAL1 is a pioneer-like transcription factor."
Menet J.S. , Pescatore S. , Rosbash M.
Genes Dev.28:8-13(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
56.

"CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1."
Zhou B. , Zhang Y. , Zhang F. , Xia Y. , Liu J. , Huang R. , Wang Y. , Hu Y. , Wu J. , Dai C. , Wang H. , Tu Y. , Peng X. , Wang Y. , Zhai Q.
Hepatology59:2196-2206(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
57.

"Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression."
Annayev Y. , Adar S. , Chiou Y.Y. , Lieb J. , Sancar A. , Ye R.
J. Biol. Chem.289:5013-5024(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
58.

"Modulation of glucocorticoid receptor induction properties by core circadian clock proteins."
Han D.H. , Lee Y.J. , Kim K. , Kim C.J. , Cho S.
Mol. Cell. Endocrinol.383:170-180(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GR REPRESSION
59.

"Molecular architecture of the mammalian circadian clock."
Partch C.L. , Green C.B. , Takahashi J.S.
Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
60.

"Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex."
Huang N. , Chelliah Y. , Shan Y. , Taylor C.A. , Yoo S.H. , Partch C. , Green C.B. , Zhang H. , Takahashi J.S.
Science337:189-194(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 26-384 IN COMPLEX WITH ARNTL;FUNCTION;INTERACTION WITH ARNTL;MUTAGENESIS OF LEU-57; LEU-74 AND TRP-284

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