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Index > Protein center > CMTR1(Gene name) > Human
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  • CMTR1 (Gene name),
  • Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Protein name ),  CMTR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CMTR1(FTSJD2;KIAA0082;MTR1);
    Protein name:
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1;
    Alternative:
    Cap1 2'O-ribose methyltransferase 1(MTr1);Cap methyltransferase 1;Interferon-stimulated gene 95 kDa protein(ISG95);FtsJ methyltransferase domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with POLR2A (via C-terminus).
    Function:
    S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    835
    Sequence:
    50:
    MKRRTDPECT | APIKKQKKRV | AELALSLSST | SDDEPPSSVS | HGAKASTTSL | 
    100:
    SGSDSETEGK | QHSSDSFDDA | FKADSLVEGT | SSRYSMYNSV | SQKLMAKMGF | 
    150:
    REGEGLGKYS | QGRKDIVEAS | SQKGRRGLGL | TLRGFDQELN | VDWRDEPEPS | 
    200:
    ACEQVSWFPE | CTTEIPDTQE | MSDWMVVGKR | KMIIEDETEF | CGEELLHSVL | 
    250:
    QCKSVFDVLD | GEEMRRARTR | ANPYEMIRGV | FFLNRAAMKM | ANMDFVFDRM | 
    300:
    FTNPRDSYGK | PLVKDREAEL | LYFADVCAGP | GGFSEYVLWR | KKWHAKGFGM | 
    350:
    TLKGPNDFKL | EDFYSASSEL | FEPYYGEGGI | DGDGDITRPE | NISAFRNFVL | 
    400:
    DNTDRKGVHF | LMADGGFSVE | GQENLQEILS | KQLLLCQFLM | ALSIVRTGGH | 
    450:
    FICKTFDLFT | PFSVGLVYLL | YCCFERVCLF | KPITSRPANS | ERYVVCKGLK | 
    500:
    VGIDDVRDYL | FAVNIKLNQL | RNTDSDVNLV | VPLEVIKGDH | EFTDYMIRSN | 
    550:
    ESHCSLQIKA | LAKIHAFVQD | TTLSEPRQAE | IRKECLRLWG | IPDQARVAPS | 
    600:
    SSDPKSKFFE | LIQGTEIDIF | SYKPTLLTSK | TLEKIRPVFD | YRCMVSGSEQ | 
    650:
    KFLIGLGKSQ | IYTWDGRQSD | RWIKLDLKTE | LPRDTLLSVE | IVHELKGEGK | 
    700:
    AQRKISAIHI | LDVLVLNGTD | VREQHFNQRI | QLAEKFVKAV | SKPSRPDMNP | 
    750:
    IRVKEVYRLE | EMEKIFVRLE | MKIIKGSSGT | PKLSYTGRDD | RHFVPMGLYI | 
    800:
    VRTVNEPWTM | GFSKSFKKKF | FYNKKTKDST | FDLPADSIAP | FHICYYGRLF | 
    835:
    WEWGDGIRVH | DSQKPQDQDK | LSKEDVLSFI | QMHRA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

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    Linearity
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    References
    1. 1.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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    2. 2.
      Ohara O. , Nagase T. , Kikuno R. , Nomura N.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
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      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
    6. 6.
      "Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein."
      Geiss G.K. , Carter V.S. , He Y. , Kwieciszewski B.K. , Holzman T. , Korth M.J. , Lazaro C.A. , Fausto N. , Bumgarner R.E. , Katze M.G.
      J. Virol.77:6367-6375(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY INTERFERONS ALPHA AND BETA
    7. 7.
      "Cellular gene expression survey of vaccinia virus infection of human HeLa cells."
      Guerra S. , Lopez-Fernandez L.A. , Pascual-Montano A. , Munoz M. , Harshman K. , Esteban M.
      J. Virol.77:6493-6506(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY VIRAL INFECTION
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity."
      Haline-Vaz T. , Silva T.C.L. , Zanchin N.I.T.
      Biochem. Biophys. Res. Commun.372:719-724(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH POLR2A;SUBCELLULAR LOCATION;INDUCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Characterization of hMTr1, a human Cap1 2'-O-Ribose methyltransferase."
      Belanger F. , Stepinski J. , Darzynkiewicz E. , Pelletier J.
      J. Biol. Chem.285:33037-33044(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family."
      Werner M. , Purta E. , Kaminska K.H. , Cymerman I.A. , Campbell D.A. , Mittra B. , Zamudio J.R. , Sturm N.R. , Jaworski J. , Bujnicki J.M.
      Nucleic Acids Res.39:4756-4768(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ACTIVE SITE;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-239; ASP-364 AND LYS-404
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