Gene name:
CMTR1 (FTSJD2;KIAA0082;MTR1) ;
Protein name:
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 ;
Alternative:
Cap1 2'O-ribose methyltransferase 1 (MTr1) ;Cap methyltransferase 1 ;Interferon-stimulated gene 95 kDa protein (ISG95) ;FtsJ methyltransferase domain-containing protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with POLR2A (via C-terminus).
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKRRTDPECT | APIKKQKKRV | AELALSLSST | SDDEPPSSVS | HGAKASTTSL |
100:
SGSDSETEGK | QHSSDSFDDA | FKADSLVEGT | SSRYSMYNSV | SQKLMAKMGF |
150:
REGEGLGKYS | QGRKDIVEAS | SQKGRRGLGL | TLRGFDQELN | VDWRDEPEPS |
200:
ACEQVSWFPE | CTTEIPDTQE | MSDWMVVGKR | KMIIEDETEF | CGEELLHSVL |
250:
QCKSVFDVLD | GEEMRRARTR | ANPYEMIRGV | FFLNRAAMKM | ANMDFVFDRM |
300:
FTNPRDSYGK | PLVKDREAEL | LYFADVCAGP | GGFSEYVLWR | KKWHAKGFGM |
350:
TLKGPNDFKL | EDFYSASSEL | FEPYYGEGGI | DGDGDITRPE | NISAFRNFVL |
400:
DNTDRKGVHF | LMADGGFSVE | GQENLQEILS | KQLLLCQFLM | ALSIVRTGGH |
450:
FICKTFDLFT | PFSVGLVYLL | YCCFERVCLF | KPITSRPANS | ERYVVCKGLK |
500:
VGIDDVRDYL | FAVNIKLNQL | RNTDSDVNLV | VPLEVIKGDH | EFTDYMIRSN |
550:
ESHCSLQIKA | LAKIHAFVQD | TTLSEPRQAE | IRKECLRLWG | IPDQARVAPS |
600:
SSDPKSKFFE | LIQGTEIDIF | SYKPTLLTSK | TLEKIRPVFD | YRCMVSGSEQ |
650:
KFLIGLGKSQ | IYTWDGRQSD | RWIKLDLKTE | LPRDTLLSVE | IVHELKGEGK |
700:
AQRKISAIHI | LDVLVLNGTD | VREQHFNQRI | QLAEKFVKAV | SKPSRPDMNP |
750:
IRVKEVYRLE | EMEKIFVRLE | MKIIKGSSGT | PKLSYTGRDD | RHFVPMGLYI |
800:
VRTVNEPWTM | GFSKSFKKKF | FYNKKTKDST | FDLPADSIAP | FHICYYGRLF |
835:
WEWGDGIRVH | DSQKPQDQDK | LSKEDVLSFI | QMHRA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
ELISA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CLIA Kit for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Polyclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Monoclonal Antibody for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Protein for Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Lung .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION BY INTERFERONS ALPHA AND BETA
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION BY VIRAL INFECTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH POLR2A;SUBCELLULAR LOCATION;INDUCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
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Cited for : FUNCTION;CATALYTIC ACTIVITY;ACTIVE SITE;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-239; ASP-364 AND LYS-404