Protein name:
Cyclic nucleotide-gated cation channel alpha-3 ;
Alternative:
Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3;CNG-3;CNG3) ;Cone photoreceptor cGMP-gated channel subunit alpha ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterooligomeric complex with CNGB3.
Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MAKVNTQCSQ | PSPTQLSIKN | ADRDLDHVEN | GLGRVSRLII | SIRAWASRHL |
100:
HDEDQTPDSF | LDRFHGSELK | EVSTRESNAQ | PNPGEQKPPD | GGEGRKEEPI |
150:
VVDPSSNIYY | RWLTAIALPV | FYNWCLLVCR | ACFDELQSEH | LTLWLVLDYS |
200:
ADVLYVLDML | VRARTGFLEQ | GLMVRDTKRL | WKHYTKTLHF | KLDILSLIPT |
250:
DLAYLKLGVN | YPELRFNRLL | KFSRLFEFFD | RTETRTNYPN | VFRIGNLVLY |
300:
TLIIIHWNAC | IYFAISKFIG | FGTDSWVYPN | TSKPEYARLS | RKYIYSLYWS |
350:
TLTLTTIGET | PPPVKDEEYL | FVVIDFLVGI | LIFATIVGNV | GSMISNMNAP |
400:
RVEFQAKIDS | VKQYMQFRKV | TKDLETRVIR | WFDYLWANRK | TVDEKEVLKN |
450:
LPDKLKAEIA | INVHLDTLKK | VRIFQDCEAG | LLVELVLKLR | PTVFSPGDYI |
500:
CKKGDIGREM | YIIKEGKLAV | VADDGVTQFV | VLSDGSYFGE | ISILNIKGSK |
550:
SGNRRTANIR | SIGYSDLFCL | SKDDLMEALT | EYPDAKRALE | EKGRQILMKD |
600:
NLIDEDLVAA | RVDTRDVEEK | VEYLESSLDI | LQTRFARLLA | EYSASQMKLK |
631:
QRLTRLESQM | NRRCCGFSPD | RENSEDASKT | D
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3
Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3
Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 .
tissue :
Retina .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-631
strain :
129/Sv .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT