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Index > Protein center > Cnga3(Gene name) > Mouse
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  • Cnga3 (Gene name),
  • Cyclic nucleotide-gated cation channel alpha-3 (Protein name ),  CNGA3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cnga3(Cng3);
    Protein name:
    Cyclic nucleotide-gated cation channel alpha-3;
    Alternative:
    Cyclic nucleotide-gated channel alpha-3(CNG channel alpha-3;CNG-3;CNG3);Cone photoreceptor cGMP-gated channel subunit alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterooligomeric complex with CNGB3.
    Function:
    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    631
    Sequence:
    50:
    MAKVNTQCSQ | PSPTQLSIKN | ADRDLDHVEN | GLGRVSRLII | SIRAWASRHL | 
    100:
    HDEDQTPDSF | LDRFHGSELK | EVSTRESNAQ | PNPGEQKPPD | GGEGRKEEPI | 
    150:
    VVDPSSNIYY | RWLTAIALPV | FYNWCLLVCR | ACFDELQSEH | LTLWLVLDYS | 
    200:
    ADVLYVLDML | VRARTGFLEQ | GLMVRDTKRL | WKHYTKTLHF | KLDILSLIPT | 
    250:
    DLAYLKLGVN | YPELRFNRLL | KFSRLFEFFD | RTETRTNYPN | VFRIGNLVLY | 
    300:
    TLIIIHWNAC | IYFAISKFIG | FGTDSWVYPN | TSKPEYARLS | RKYIYSLYWS | 
    350:
    TLTLTTIGET | PPPVKDEEYL | FVVIDFLVGI | LIFATIVGNV | GSMISNMNAP | 
    400:
    RVEFQAKIDS | VKQYMQFRKV | TKDLETRVIR | WFDYLWANRK | TVDEKEVLKN | 
    450:
    LPDKLKAEIA | INVHLDTLKK | VRIFQDCEAG | LLVELVLKLR | PTVFSPGDYI | 
    500:
    CKKGDIGREM | YIIKEGKLAV | VADDGVTQFV | VLSDGSYFGE | ISILNIKGSK | 
    550:
    SGNRRTANIR | SIGYSDLFCL | SKDDLMEALT | EYPDAKRALE | EKGRQILMKD | 
    600:
    NLIDEDLVAA | RVDTRDVEEK | VEYLESSLDI | LQTRFARLLA | EYSASQMKLK | 
    631:
    QRLTRLESQM | NRRCCGFSPD | RENSEDASKT | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    E14024m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    E14024h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    E14024b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    U14024b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    U14024h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    U14024m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    P14024Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Cat.:
    P14024Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3
    Protein for Mouse Cyclic nucleotide-gated cation channel alpha-3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina."
      Hirano A.A. , Hack I. , Waessle H. , Duvoisin R.M.
      J. Comp. Neurol.421:80-94(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
      tissue: Retina.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    3. 3.
      "Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3."
      Biel M. , Seeliger M. , Pfeifer A. , Kohler K. , Gerstner A. , Ludwig A. , Jaissle G. , Fauser S. , Zrenner E. , Hofmann F.
      Proc. Natl. Acad. Sci. U.S.A.96:7553-7557(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-631
      strain: 129/Sv.
    4. 4.
      "Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina."
      Gerstner A. , Zong X. , Hofmann F. , Biel M.
      J. Neurosci.20:1324-1332(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
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