CNGB1 ELISA Kit for Human(Homo sapiens) | EIAab.comCNGB1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CNGB1 (Gene name),

Cyclic nucleotide-gated cation channel beta-1 (Protein name ), CNGB1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CNGB1(CNCG2;CNCG3L;CNCG4;RCNC2);

Protein name:

Cyclic nucleotide-gated cation channel beta-1;

Alternative:

Cyclic nucleotide-gated cation channel gamma;Cyclic nucleotide-gated cation channel 4(CNG channel 4;CNG-4;CNG4);Cyclic nucleotide-gated channel beta-1(CNG channel beta-1);Cyclic nucleotide-gated cation channel modulatory subunit;Glutamic acid-rich protein(GARP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterooligomeric complex with CNGA1.

Function:

Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1251

Sequence:

50:

MLGWVQRVLP | QPPGTPRKTK | MQEEEEVEPE | PEMEAEVEPE | PNPEEAETES |

100:

ESMPPEESFK | EEEVAVADPS | PQETKEAALT | STISLRAQGA | EISEMNSPSR |

150:

RVLTWLMKGV | EKVIPQPVHS | ITEDPAQILG | HGSTGDTGCT | DEPNEALEAQ |

200:

DTRPGLRLLL | WLEQNLERVL | PQPPKSSEVW | RDEPAVATGA | ASDPAPPGRP |

250:

QEMGPKLQAR | ETPSLPTPIP | LQPKEEPKEA | PAPEPQPGSQ | AQTSSLPPTR |

300:

DPARLVAWVL | HRLEMALPQP | VLHGKIGEQE | PDSPGICDVQ | TISILPGGQV |

350:

EPDLVLEEVE | PPWEDAHQDV | STSPQGTEVV | PAYEEENKAV | EKMPRELSRI |

400:

EEEKEDEEEE | EEEEEEEEEE | EVTEVLLDSC | VVSQVGVGQS | EEDGTRPQST |

450:

SDQKLWEEVG | EEAKKEAEEK | AKEEAEEVAE | EEAEKEPQDW | AETKEEPEAE |

500:

AEAASSGVPA | TKQHPEVQVE | DTDADSCPLM | AEENPPSTVL | PPPSPAKSDT |

550:

LIVPSSASGT | HRKKLPSEDD | EAEELKALSP | AESPVVAWSD | PTTPKDTDGQ |

600:

DRAASTASTN | SAIINDRLQE | LVKLFKERTE | KVKEKLIDPD | VTSDEESPKP |

650:

SPAKKAPEPA | PDTKPAEAEP | VEEEHYCDML | CCKFKHRPWK | KYQFPQSIDP |

700:

LTNLMYVLWL | FFVVMAWNWN | CWLIPVRWAF | PYQTPDNIHH | WLLMDYLCDL |

750:

IYFLDITVFQ | TRLQFVRGGD | IITDKKDMRN | NYLKSRRFKM | DLLSLLPLDF |

800:

LYLKVGVNPL | LRLPRCLKYM | AFFEFNSRLE | SILSKAYVYR | VIRTTAYLLY |

850:

SLHLNSCLYY | WASAYQGLGS | THWVYDGVGN | SYIRCYYFAV | KTLITIGGLP |

900:

DPKTLFEIVF | QLLNYFTGVF | AFSVMIGQMR | DVVGAATAGQ | TYYRSCMDST |

950:

VKYMNFYKIP | KSVQNRVKTW | YEYTWHSQGM | LDESELMVQL | PDKMRLDLAI |

1000:

DVNYNIVSKV | ALFQGCDRQM | IFDMLKRLRS | VVYLPNDYVC | KKGEIGREMY |

1050:

IIQAGQVQVL | GGPDGKSVLV | TLKAGSVFGE | ISLLAVGGGN | RRTANVVAHG |

1100:

FTNLFILDKK | DLNEILVHYP | ESQKLLRKKA | RRMLRSNNKP | KEEKSVLILP |

1150:

PRAGTPKLFN | AALAMTGKMG | GKGAKGGKLA | HLRARLKELA | ALEAAAKQQE |

1200:

LVEQAKSSQD | VKGEEGSAAP | DQHTHPKEAA | TDPPAPRTPP | EPPGSPPSSP |

1250:

PPASLGRPEG | EEEGPAEPEE | HSVRICMSPG | PEPGEQILSV | KMPEEREEKA |

1251:

E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

String:

MIM:

STRING:

9606.ENSP00000251102

UniGene:

SMR:

KEGG:

Uniprot:

FOR

ELISA Kit for Human Cyclic nucleotide-gated cation channel beta-1

ELISA Kit for Human Cyclic nucleotide-gated cation channel beta-1

CLIA Kit for Human Cyclic nucleotide-gated cation channel beta-1

CLIA Kit for Human Cyclic nucleotide-gated cation channel beta-1

Polyclonal Antibody for Human Cyclic nucleotide-gated cation channel beta-1

Polyclonal Antibody for Human Cyclic nucleotide-gated cation channel beta-1

Monoclonal Antibody for Human Cyclic nucleotide-gated cation channel beta-1

Monoclonal Antibody for Human Cyclic nucleotide-gated cation channel beta-1

Protein for Human Cyclic nucleotide-gated cation channel beta-1

Protein for Human Cyclic nucleotide-gated cation channel beta-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A new subunit of the cyclic nucleotide-gated cation channel in retinal rods."
Chen T.-Y. , Peng Y.-W. , Dhallan R.S. , Ahamed B. , Reed R.R. , Yau K.-W.
Nature362:764-767(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS RCNC2A AND RCNC2B)
tissue: Retina.
2.

"cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel."
Ardell M.D. , Makhija A.K. , Oliveira L. , Miniou P. , Viegas-Pequignot E. , Pittler S.J.
Genomics28:32-38(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GARP2);VARIANT HIS-100
tissue: Retina.
3.

"The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit."
Ardell M.D. , Aragon I. , Oliveira L. , Porche G.E. , Burke E. , Pittler S.J.
FEBS Lett.389:213-218(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RCNC2B);VARIANT HIS-100
tissue: Retina.
4.

"Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin."
Grunwald M.E. , Yu W.P. , Yu H.H. , Yau K.W.
J. Biol. Chem.273:9148-9157(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RCNC2B);FUNCTION;VARIANT HIS-100
tissue: Retina.
5.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene."
Ardell M.D. , Bedsole D.L. , Schoborg R.V. , Pittler S.J.
Gene245:311-318(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
8.

"Calmodulin permanently associates with rat olfactory CNG channels under native conditions."
Bradley J. , Boenigk W. , Yau K.-W. , Frings S.
Nat. Neurosci.7:705-710(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-568
9.

"The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties."
Pentia D.C. , Hosier S. , Cote R.H.
J. Biol. Chem.281:5500-5505(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM GARP2);FUNCTION
10.

"Glutamic acid-rich proteins of rod photoreceptors are natively unfolded."
Batra-Safferling R. , Abarca-Heidemann K. , Korschen H.G. , Tziatzios C. , Stoldt M. , Budyak I. , Willbold D. , Schwalbe H. , Klein-Seetharaman J. , Kaupp U.B.
J. Biol. Chem.281:1449-1460(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE GARPS PROTEINS
11.

Cote R.H.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM GARP2)
12.

"Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa."
Bareil C. , Hamel C.P. , Delague V. , Arnaud B. , Demaille J. , Claustres M.
Hum. Genet.108:328-334(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RP45 VAL-993

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