CNOT1 ELISA Kit for Human(Homo sapiens) | EIAab.comCNOT1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CNOT1(Gene name) > Human

CNOT1 (Gene name),

CCR4-NOT transcription complex subunit 1 (Protein name ), CNOT1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CNOT1(AD-005;CDC39;KIAA1007;NOT1);

Protein name:

CCR4-NOT transcription complex subunit 1;

Alternative:

Negative regulator of transcription subunit 1 homolog(NOT1H;hNOT1);CCR4-associated factor 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Subunit of the CCR4-NOT core complex that contains CNOT1, CNOT2, CNOT3, CNOT4 and CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2.

Function:

Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.

Subcellular Location:

Cytoplasm P-body NANOS2 promotes its localization to P-body.

Protein Attributes:

Sequence length:

2376

Sequence:

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2376:

KLFQSVAQCC | MGQKQAQQVM | EGTGAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

A5YKK6

MIM:

604917

Pfam:

PF12842

KEGG:

hsa:23019

UniGene:

Hs.460923

SMR:

A5YKK6

Uniprot:

A5YKK6

FOR

ELISA Kit for Human CCR4-NOT transcription complex subunit 1

CLIA Kit for Human CCR4-NOT transcription complex subunit 1

Polyclonal Antibody for Human CCR4-NOT transcription complex subunit 1

Monoclonal Antibody for Human CCR4-NOT transcription complex subunit 1

Protein for Human CCR4-NOT transcription complex subunit 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-2376 (ISOFORM 1)
tissue: Cervix.
tissue: Fetal kidney.
tissue: Testis.
2.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 757-2376 (ISOFORM 1);VARIANT ALA-603
tissue: Choriocarcinoma.
tissue: Leiomyosarcoma.
tissue: Testis.
4.

"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.6:63-70(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 537-2376 (ISOFORM 2)
tissue: Brain.
5.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
6.

"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M. , Han Z.-G. , Song H.-D. , Peng Y.-D. , Huang Q.-H. , Ren S.-X. , Gu Y.-J. , Huang C.-H. , Li Y.-B. , Jiang C.-L. , Fu G. , Zhang Q.-H. , Gu B.-W. , Dai M. , Mao Y.-F. , Gao G.-F. , Rong R. , Ye M. , more...
Proc. Natl. Acad. Sci. U.S.A.97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1964-2374 (ISOFORM 1)
tissue: Adrenal gland.
7.

"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
Albert T.K. , Lemaire M. , van Berkum N.L. , Gentz R. , Collart M.A. , Timmers H.T.M.
Nucleic Acids Res.28:809-817(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CNOT2; CNOT4 AND CNOT8;TISSUE SPECIFICITY
8.

"Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription."
Winkler G.S. , Mulder K.W. , Bardwell V.J. , Kalkhoven E. , Timmers H.T.
EMBO J.25:3089-3099(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;INTERACTION WITH CNOT2; CNOT3; CNOT8; ESR1 AND RXRA
9.

"Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex."
Miyasaka T. , Morita M. , Ito K. , Suzuki T. , Fukuda H. , Takeda S. , Inoue J. , Semba K. , Yamamoto T.
Cancer Sci.99:755-761(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TOB1
10.

"Human Ccr4-Not complexes contain variable deadenylase subunits."
Lau N.C. , Kolkman A. , van Schaik F.M. , Mulder K.W. , Pijnappel W.W. , Heck A.J. , Timmers H.T.
Biochem. J.422:443-453(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX;COMPOSITION OF THE CCR4-NOT COMPLEX
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets."
Braun J.E. , Huntzinger E. , Fauser M. , Izaurralde E.
Mol. Cell44:120-133(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNRC6A; TNRC6B AND TNRC6C
13.

"miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT."
Fabian M.R. , Cieplak M.K. , Frank F. , Morita M. , Green J. , Srikumar T. , Nagar B. , Yamamoto T. , Raught B. , Duchaine T.F. , Sonenberg N.
Nat. Struct. Mol. Biol.18:1211-1217(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TNRC6C
14.

"Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin."
Sandler H. , Kreth J. , Timmers H.T. , Stoecklin G.
Nucleic Acids Res.39:4373-4386(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZFP36
15.

"The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability."
Ito K. , Takahashi A. , Morita M. , Suzuki T. , Yamamoto T.
Protein Cell2:755-763(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
16.

"Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
Zheng X. , Dumitru R. , Lackford B.L. , Freudenberg J.M. , Singh A.P. , Archer T.K. , Jothi R. , Hu G.
Stem Cells30:910-922(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
17.

"The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex."
Petit A.P. , Wohlbold L. , Bawankar P. , Huntzinger E. , Schmidt S. , Izaurralde E. , Weichenrieder O.
Nucleic Acids Res.40:11058-11072(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1093-1317 IN COMPLEX WITH CNOT7;INTERACTION WITH CNOT8; CNOT6 AND CNOT6L;MUTAGENESIS OF LYS-1208; HIS-1212 AND LYS-1218
18.

"Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin."
Fabian M.R. , Frank F. , Rouya C. , Siddiqui N. , Lai W.S. , Karetnikov A. , Blackshear P.J. , Nagar B. , Sonenberg N.
Nat. Struct. Mol. Biol.20:735-739(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 800-1004 IN COMPLEX WITH ZFP36;INTERACTION WITH ZFP36;FUNCTION

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