COL4A2 ELISA Kit for Human(Homo sapiens) | EIAab.comCOL4A2 ELISA Kit for Human(Homo sapiens)

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COL4A2 (Gene name),

Collagen alpha-2(IV) chain (Protein name ), CO4A2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

COL4A2;

Protein name:

Collagen alpha-2(IV) chain;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.

Function:

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Subcellular Location:

Secreted extracellular space extracellular matrix basement membrane

Protein Attributes:

Sequence length:

1712

Sequence:

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1450:

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1650:

1700:

1712:

HISRCQVCMK | NL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.508716

STRING:

9606.ENSP00000353654

String:

P08572

SMR:

P08572

KEGG:

hsa:1284

Pfam:

PF01413

MIM:

120090

Uniprot:

P08572

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ELISA Kit for Human Collagen alpha-2(IV) chain

Cat.:

E9536h

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96T

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ELISA Kit for Human Collagen alpha-2(IV) chain

Cat.:

E9536b

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96T

ELISA Kit for Human Collagen alpha-2(IV) chain

Cat.:

E9536m

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96T

CLIA Kit for Human Collagen alpha-2(IV) chain

Cat.:

U9536b

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Packing:

96T

CLIA Kit for Human Collagen alpha-2(IV) chain

Cat.:

U9536m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-2(IV) chain

Cat.:

U9536h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Collagen alpha-2(IV) chain

Cat.:

P9536Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Collagen alpha-2(IV) chain

Cat.:

P9536Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Collagen alpha-2(IV) chain

Protein for Human Collagen alpha-2(IV) chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain."
Hostikka S.L. , Tryggvason K.
J. Biol. Chem.263:19488-19493(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain."
Brazel D. , Pollner R. , Oberbaeumer I. , Kuehn K.
Eur. J. Biochem.172:35-42(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1042;VARIANTS LYS-517 AND ALA-683
tissue: Placenta.
4.

"The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure."
Poeschl E. , Pollner R. , Kuehn K.
EMBO J.7:2687-2695(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
5.

"The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region."
Soininen R. , Huotari M. , Hostikka S.L. , Prockop D.J. , Tryggvason K.
J. Biol. Chem.263:17217-17220(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
6.

"Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription."
Fischer G. , Schmidt C. , Opitz J. , Cully Z. , Kuehn K. , Poeschl E.
Biochem. J.292:687-695(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
tissue: Skin.
7.

"Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2)."
Killen P.D. , Francomano C.A. , Yamada Y. , Modi W.S. , O'Brien S.J.
Hum. Genet.77:318-324(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1040-1712
tissue: Placenta.
8.

"Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region."
Hostikka S.L. , Kurkinen M. , Tryggvason K.
FEBS Lett.216:281-286(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1254-1712;VARIANT ILE-1399
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1351-1712
tissue: Eye.
10.

"Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13."
Griffin C.A. , Emanuel B.S. , Hansen J.R. , Cavenee W.K. , Myers J.C.
Proc. Natl. Acad. Sci. U.S.A.84:512-516(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1451-1485
11.

"The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen."
Siebold B. , Deutzmann R. , Kuehn K.
Eur. J. Biochem.176:617-624(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1480-1535; 1545-1614; 1617-1701 AND 1705-1712
tissue: Placenta.
12.

"Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes."
Myers J.C. , Howard P.S. , Jelen A.M. , Dion A.S. , Macarak E.J.
J. Biol. Chem.262:9231-9238(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1486-1712
13.

"Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth."
Kamphaus G.D. , Colorado P.C. , Panka D.J. , Hopfer H. , Ramchandran R. , Torre A. , Maeshima Y. , Mier J.W. , Sukhatme V.P. , Kalluri R.
J. Biol. Chem.275:1209-1215(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1486-1712;FUNCTION
14.

Peng X. , Sun W. , Yin B. , Yuan J. , Qiang B.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1486-1712
15.

"Molecular cloning and homologous sequence analysis of canstatin cDNA derived from Chinese hepatocytes."
Li Y. , Huang G. , Qian G.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1486-1712
tissue: Hepatocyte.
16.

"Cloning and expression of canstatin in yeast."
Shan Z.X. , Yu X.Y. , Lin Q.X. , Fu Y.H. , Yang M. , Tan H.H.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1486-1712
17.

"Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells."
Panka D.J. , Mier J.W.
J. Biol. Chem.278:37632-37636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF CANSTATIN
18.

"Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins."
Magnon C. , Galaup A. , Mullan B. , Rouffiac V. , Bouquet C. , Bidart J.M. , Griscelli F. , Opolon P. , Perricaudet M.
Cancer Res.65:4353-4361(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF CANSTATIN
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link."
Than M.E. , Henrich S. , Huber R. , Ries A. , Mann K. , Kuhn K. , Timpl R. , Bourenkov G.P. , Bartunik H.D. , Bode W.
Proc. Natl. Acad. Sci. U.S.A.99:6607-6612(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1485-1712
21.

"Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus."
Karolak J.A. , Kulinska K. , Nowak D.M. , Pitarque J.A. , Molinari A. , Rydzanicz M. , Bejjani B.A. , Gajecka M.
Mol. Vis.17:827-843(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-192; LYS-517; ALA-683; ARG-701 AND SER-718
22.

"De novo and inherited mutations in COL4A2, encoding the type IV collagen alpha2 chain cause porencephaly."
Yoneda Y. , Haginoya K. , Arai H. , Yamaoka S. , Tsurusaki Y. , Doi H. , Miyake N. , Yokochi K. , Osaka H. , Kato M. , Matsumoto N. , Saitsu H.
Am. J. Hum. Genet.90:86-90(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS POREN2 GLU-1037 AND ASP-1152
23.

"COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke."
Jeanne M. , Labelle-Dumais C. , Jorgensen J. , Kauffman W.B. , Mancini G.M. , Favor J. , Valant V. , Greenberg S.M. , Rosand J. , Gould D.B.
Am. J. Hum. Genet.90:91-101(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ICH;VARIANTS PHE-192; LYS-517; ALA-683; ARG-701; SER-718; GLN-1109; GLY-1123; LYS-1150; ILE-1399 AND THR-1690;CHARACTERIZATION OF VARIANTS GLY-1123; LYS-1150 AND THR-1690
24.

"COL4A2 mutation associated with familial porencephaly and small-vessel disease."
Verbeek E. , Meuwissen M.E. , Verheijen F.W. , Govaert P.P. , Licht D.J. , Kuo D.S. , Poulton C.J. , Schot R. , Lequin M.H. , Dudink J. , Halley D.J. , de Coo R.I. , den Hollander J.C. , Oegema R. , Gould D.B. , Mancini G.M.
Eur. J. Hum. Genet.20:844-851(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-1389

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