Protein name:
Collagen alpha-4(IV) chain ;
Alternative:
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively. Associates with LAMB2 at the neuromuscular junction and in GBM.
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
basement membrane
Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
Protein Attributes:
50:
GPKGNKGDAA | SQFGPPGPKG | EPGSRGYQGH | FGGPGEQGFP | GVQGHRGPPG |
100:
RPGSPGSSGP | PGCPGGQGIP | GLEGHPGEVG | DPGPRGLLGD | PGRPGPPGMK |
150:
GPSGSPGLDG | LHGLKGQKGT | KGASGLHEMG | PPGPMGIPGI | KGDKGEPGSP |
200:
GISPPGLFGE | RGPPGLPGRP | GPVGPMGATG | RAPKGDIPDP | GPPGDQGLPG |
250:
PDGPRGAPGP | AGPPGSVDLL | KGEPGDCGVP | GPPGPPGPPG | PPGCQGVPGC |
300:
DGHDGQKGPM | GFPGLQGPHG | LPGLPGEKGL | PGSPGRKGPT | GPPGYRGEPG |
350:
PPADEDSCPR | IPGLPGVPGP | RGPEGAMGFP | GQRGPPGQGC | KGEPGLDGKR |
400:
GRDGVPGAPG | PPGHKGDTGE | AGRPGAPGPP | GPTGDPGPKG | LGPGYLSGFL |
450:
LVLHSQTDQE | PACPMGMPRL | WTGYSLLYLE | GQEKAHNQDL | GLAGSCLPIF |
500:
STLPFAYCNI | HQVCHYAQRN | DKSYWLASAG | PLPMMPLSEE | EIRPYISRCA |
550:
VCEAPAQAVA | VHSQDQSIPP | CPRAWRSLWI | GYSFLMHTGA | GDQGGGQALM |
600:
SPGSCLEDFR | AAPFLECQGR | QGTCHFFANE | YSFWLTTVPP | DLQVFSAPSP |
623:
DTLKESQAQR | QKISRCQVCV | KYS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rabbit
ELISA Kit for Rabbit Collagen alpha-4(IV) chain
ELISA Kit for Rabbit Collagen alpha-4(IV) chain
ELISA Kit for Rabbit Collagen alpha-4(IV) chain
ELISA Kit for Rabbit Collagen alpha-4(IV) chain
CLIA Kit for Rabbit Collagen alpha-4(IV) chain
CLIA Kit for Rabbit Collagen alpha-4(IV) chain
CLIA Kit for Rabbit Collagen alpha-4(IV) chain
CLIA Kit for Rabbit Collagen alpha-4(IV) chain
Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
Protein for Rabbit Collagen alpha-4(IV) chain
Protein for Rabbit Collagen alpha-4(IV) chain
Protein for Rabbit Collagen alpha-4(IV) chain
Protein for Rabbit Collagen alpha-4(IV) chain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Corneal endothelium .