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Index > Protein center > COL4A4(Gene name) > Rabbit
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  • COL4A4 (Gene name),
  • Collagen alpha-4(IV) chain (Protein name ),  CO4A4_RABIT from NCBI database.
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  • Gene name:
    COL4A4;
    Protein name:
    Collagen alpha-4(IV) chain;
    Alternative:

    Organism:
    Rabbit (Oryctolagus cuniculus). 
    General Annotation
    Sub Unit:
    There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively. Associates with LAMB2 at the neuromuscular junction and in GBM.
    Function:
    Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
    Protein Attributes:
    Sequence length:
    623
    Sequence:
    50:
    GPKGNKGDAA | SQFGPPGPKG | EPGSRGYQGH | FGGPGEQGFP | GVQGHRGPPG | 
    100:
    RPGSPGSSGP | PGCPGGQGIP | GLEGHPGEVG | DPGPRGLLGD | PGRPGPPGMK | 
    150:
    GPSGSPGLDG | LHGLKGQKGT | KGASGLHEMG | PPGPMGIPGI | KGDKGEPGSP | 
    200:
    GISPPGLFGE | RGPPGLPGRP | GPVGPMGATG | RAPKGDIPDP | GPPGDQGLPG | 
    250:
    PDGPRGAPGP | AGPPGSVDLL | KGEPGDCGVP | GPPGPPGPPG | PPGCQGVPGC | 
    300:
    DGHDGQKGPM | GFPGLQGPHG | LPGLPGEKGL | PGSPGRKGPT | GPPGYRGEPG | 
    350:
    PPADEDSCPR | IPGLPGVPGP | RGPEGAMGFP | GQRGPPGQGC | KGEPGLDGKR | 
    400:
    GRDGVPGAPG | PPGHKGDTGE | AGRPGAPGPP | GPTGDPGPKG | LGPGYLSGFL | 
    450:
    LVLHSQTDQE | PACPMGMPRL | WTGYSLLYLE | GQEKAHNQDL | GLAGSCLPIF | 
    500:
    STLPFAYCNI | HQVCHYAQRN | DKSYWLASAG | PLPMMPLSEE | EIRPYISRCA | 
    550:
    VCEAPAQAVA | VHSQDQSIPP | CPRAWRSLWI | GYSFLMHTGA | GDQGGGQALM | 
    600:
    SPGSCLEDFR | AAPFLECQGR | QGTCHFFANE | YSFWLTTVPP | DLQVFSAPSP | 
    623:
    DTLKESQAQR | QKISRCQVCV | KYS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    E9534h
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    96T
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    ELISA Kit for Rabbit Collagen alpha-4(IV) chain
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    E9534m
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    ELISA Kit for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    E9534b
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    Packing:
    96T
    ELISA Kit for Rabbit Collagen alpha-4(IV) chain
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    CLIA Kit for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    U9534b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    U9534m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rabbit Collagen alpha-4(IV) chain
    MSDS:
    Please sign in first.
    CLIA Kit for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    U9534h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    P9534Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Polyclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Cat.:
    P9534Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Monoclonal Antibody for Rabbit Collagen alpha-4(IV) chain
    Protein for Rabbit Collagen alpha-4(IV) chain
    Protein for Rabbit Collagen alpha-4(IV) chain
    Protein for Rabbit Collagen alpha-4(IV) chain
    Protein for Rabbit Collagen alpha-4(IV) chain

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    References
    1. 1.
      "Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2."
      Kamagata Y. , Mattei M.-G. , Ninomiya Y.
      J. Biol. Chem.267:23753-23758(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Corneal endothelium.
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