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Index > Protein center > COL5A1(Gene name) > Human
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  • COL5A1 (Gene name),
  • Collagen alpha-1(V) chain (Protein name ),  CO5A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    COL5A1;
    Protein name:
    Collagen alpha-1(V) chain;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
    Function:
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1838
    Sequence:
    50:
    MDVHTRWKAR | SALRPGAPLL | PPLLLLLLWA | PPPSRAAQPA | DLLKVLDFHN | 
    100:
    LPDGITKTTG | FCATRRSSKG | PDVAYRVTKD | AQLSAPTKQL | YPASAFPEDF | 
    150:
    SILTTVKAKK | GSQAFLVSIY | NEQGIQQIGL | ELGRSPVFLY | EDHTGKPGPE | 
    200:
    DYPLFRGINL | SDGKWHRIAL | SVHKKNVTLI | LDCKKKTTKF | LDRSDHPMID | 
    250:
    INGIIVFGTR | ILDEEVFEGD | IQQLLFVSDH | RAAYDYCEHY | SPDCDTAVPD | 
    300:
    TPQSQDPNPD | EYYTEGDGEG | ETYYYEYPYY | EDPEDLGKEP | TPSKKPVEAA | 
    350:
    KETTEVPEEL | TPTPTEAAPM | PETSEGAGKE | EDVGIGDYDY | VPSEDYYTPS | 
    400:
    PYDDLTYGEG | EENPDQPTDP | GAGAEIPTST | ADTSNSSNPA | PPPGEGADDL | 
    450:
    EGEFTEETIR | NLDENYYDPY | YDPTSSPSEI | GPGMPANQDT | IYEGIGGPRG | 
    500:
    EKGQKGEPAI | IEPGMLIEGP | PGPEGPAGLP | GPPGTMGPTG | QVGDPGERGP | 
    550:
    PGRPGLPGAD | GLPGPPGTML | MLPFRFGGGG | DAGSKGPMVS | AQESQAQAIL | 
    600:
    QQARLALRGP | AGPMGLTGRP | GPVGPPGSGG | LKGEPGDVGP | QGPRGVQGPP | 
    650:
    GPAGKPGRRG | RAGSDGARGM | PGQTGPKGDR | GFDGLAGLPG | EKGHRGDPGP | 
    700:
    SGPPGPPGDD | GERGDDGEVG | PRGLPGEPGP | RGLLGPKGPP | GPPGPPGVTG | 
    750:
    MDGQPGPKGN | VGPQGEPGPP | GQQGNPGAQG | LPGPQGAIGP | PGEKGPLGKP | 
    800:
    GLPGMPGADG | PPGHPGKEGP | PGEKGGQGPP | GPQGPIGYPG | PRGVKGADGI | 
    850:
    RGLKGTKGEK | GEDGFPGFKG | DMGIKGDRGE | IGPPGPRGED | GPEGPKGRGG | 
    900:
    PNGDPGPLGP | PGEKGKLGVP | GLPGYPGRQG | PKGSIGFPGF | PGANGEKGGR | 
    950:
    GTPGKPGPRG | QRGPTGPRGE | RGPRGITGKP | GPKGNSGGDG | PAGPPGERGP | 
    1000:
    NGPQGPTGFP | GPKGPPGPPG | KDGLPGHPGQ | RGETGFQGKT | GPPGPPGVVG | 
    1050:
    PQGPTGETGP | MGERGHPGPP | GPPGEQGLPG | LAGKEGTKGD | PGPAGLPGKD | 
    1100:
    GPPGLRGFPG | DRGLPGPVGA | LGLKGNEGPP | GPPGPAGSPG | ERGPAGAAGP | 
    1150:
    IGIPGRPGPQ | GPPGPAGEKG | APGEKGPQGP | AGRDGLQGPV | GLPGPAGPVG | 
    1200:
    PPGEDGDKGE | IGEPGQKGSK | GDKGEQGPPG | PTGPQGPIGQ | PGPSGADGEP | 
    1250:
    GPRGQQGLFG | QKGDEGPRGF | PGPPGPVGLQ | GLPGPPGEKG | ETGDVGQMGP | 
    1300:
    PGPPGPRGPS | GAPGADGPQG | PPGGIGNPGA | VGEKGEPGEA | GEPGLPGEGG | 
    1350:
    PPGPKGERGE | KGESGPSGAA | GPPGPKGPPG | DDGPKGSPGP | VGFPGDPGPP | 
    1400:
    GEPGPAGQDG | PPGDKGDDGE | PGQTGSPGPT | GEPGPSGPPG | KRGPPGPAGP | 
    1450:
    EGRQGEKGAK | GEAGLEGPPG | KTGPIGPQGA | PGKPGPDGLR | GIPGPVGEQG | 
    1500:
    LPGSPGPDGP | PGPMGPPGLP | GLKGDSGPKG | EKGHPGLIGL | IGPPGEQGEK | 
    1550:
    GDRGLPGPQG | SSGPKGEQGI | TGPSGPIGPP | GPPGLPGPPG | PKGAKGSSGP | 
    1600:
    TGPKGEAGHP | GPPGPPGPPG | EVIQPLPIQA | SRTRRNIDAS | QLLDDGNGEN | 
    1650:
    YVDYADGMEE | IFGSLNSLKL | EIEQMKRPLG | TQQNPARTCK | DLQLCHPDFP | 
    1700:
    DGEYWVDPNQ | GCSRDSFKVY | CNFTAGGSTC | VFPDKKSEGA | RITSWPKENP | 
    1750:
    GSWFSEFKRG | KLLSYVDAEG | NPVGVVQMTF | LRLLSASAHQ | NVTYHCYQSV | 
    1800:
    AWQDAATGSY | DKALRFLGSN | DEEMSYDNNP | YIRALVDGCA | TKKGYQKTVL | 
    1838:
    EIDTPKVEQV | PIVDIMFNDF | GEASQKFGFE | VGPACFMG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagen alpha-1(V) chain
    ELISA Kit for Human Collagen alpha-1(V) chain
    ELISA Kit for Human Collagen alpha-1(V) chain
    CLIA Kit for Human Collagen alpha-1(V) chain
    CLIA Kit for Human Collagen alpha-1(V) chain
    CLIA Kit for Human Collagen alpha-1(V) chain
    Polyclonal Antibody for Human Collagen alpha-1(V) chain
    Polyclonal Antibody for Human Collagen alpha-1(V) chain
    Polyclonal Antibody for Human Collagen alpha-1(V) chain
    Monoclonal Antibody for Human Collagen alpha-1(V) chain
    Monoclonal Antibody for Human Collagen alpha-1(V) chain
    Monoclonal Antibody for Human Collagen alpha-1(V) chain
    Protein for Human Collagen alpha-1(V) chain
    Protein for Human Collagen alpha-1(V) chain
    Protein for Human Collagen alpha-1(V) chain

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete primary structure of human collagen alpha 1 (V) chain."
      Takahara K. , Seto Y. , Okasawa K. , Okamoto N. , Noda A. , Yaoi Y. , Kato I.
      J. Biol. Chem.266:13124-13129(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 556-565
    2. 2.
      "The pro-alpha-1(V) collagen chain: complete primary structure, distribution of expression, and comparison with the pro-alpha-1(XI) collagen chain."
      Greenspan D.S. , Cheng W. , Hoffman G.G.
      J. Biol. Chem.266:24727-24733(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Covalent structure of collagen: amino acid sequence of three cyanogen bromide-derived peptides from human alpha 1(V) collagen chain."
      Seyer J.M. , Kang A.H.
      Arch. Biochem. Biophys.271:120-129(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 621-822;HYDROXYLATION
      tissue: Chorioamniotic membrane.
    5. 5.
      "Primary structure of the heparin-binding site of type V collagen."
      Yaoi Y. , Hashimoto K. , Koitabashi H. , Takahara K. , Ito M. , Kato I.
      Biochim. Biophys. Acta1035:139-145(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 823-950;HEPARIN-BINDING
    6. 6.
      "Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing."
      Mann K.
      Biol. Chem. Hoppe-Seyler373:69-75(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 556-571
      tissue: Placenta.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 565-576; 756-772; 1012-1029; 1219-1232 AND 1465-1477
      tissue: Chorioamniotic membrane.
    8. 8.
      "The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein."
      Tillet E. , Ruggiero F. , Nishiyama A. , Stallcup W.B.
      J. Biol. Chem.272:10769-10776(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSPG4
    9. 9.
      "Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II."
      de Paepe A. , Nuytinck L. , Hausser I. , Anton-Lamprecht I. , Naeyaert J.-M.
      Am. J. Hum. Genet.60:547-554(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;VARIANT EDS1 SER-1639
    10. 10.
      "Mutations in the COL5A1 coding sequence are not common in patients with spontaneous cervical artery dissections."
      Grond-Ginsbach C. , Weber R. , Haas J. , Orberk E. , Kunz S. , Busse O. , Hausser I. , Brandt T. , Wildemann B.
      Stroke30:1887-1890(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-229;ASSOCIATION WITH INCREASED RISK OF CERVICAL ARTERY DISSECTION
    11. 11.
      "Compound heterozygosity for a disease-causing G1489E and disease-modifying G530S substitution in COL5A1 of a patient with the classical type of Ehlers-Danlos syndrome: an explanation of intrafamilial variability?"
      Giunta C. , Steinmann B.
      Am. J. Med. Genet.90:72-79(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDS1 SER-530 AND ASP-1489
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    13. 13.
      "Homozygous Gly530Ser substitution in COL5A1 causes mild classical Ehlers-Danlos syndrome."
      Giunta C. , Nuytinck L. , Raghunath M. , Hausser I. , De Paepe A. , Steinmann B.
      Am. J. Med. Genet.109:284-290(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EDS2 SER-530
    14. 14.
      "The molecular basis of classic Ehlers-Danlos syndrome: a comprehensive study of biochemical and molecular findings in 48 unrelated patients."
      Malfait F. , Coucke P. , Symoens S. , Loeys B. , Nuytinck L. , De Paepe A.
      Hum. Mutat.25:28-37(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDS1/EDS2 SER-530 AND CYS-1486;VARIANTS ASP-114; ASN-192; SER-393 AND SER-951
    15. 15.
      "COL5A1 signal peptide mutations interfere with protein secretion and cause classic Ehlers-Danlos syndrome."
      Symoens S. , Malfait F. , Renard M. , Andre J. , Hausser I. , Loeys B. , Coucke P. , De Paepe A.
      Hum. Mutat.30:E395-E403(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDS1/EDS2 ARG-25 AND PRO-25;CHARACTERIZATION OF VARIANTS EDS1/EDS2 ARG-25 AND PRO-25
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-908
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